Assessing Trigeminal Neuralgia with Advanced MRI Techniques
Official title: Assessment in Patients With Essential Trigeminal Neuralgia of Nerve Involvement by MRI in DTI and Functional Connectivity in "Resting State"
Run by Fondation Ophtalmologique Adolphe de Rothschild · NCT05051072 · Data updated 2026-11-12
This study is testing advanced MRI techniques to see if they can help doctors understand the causes of trigeminal neuralgia better and improve treatment options for patients.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | April 27, 2022 |
| Main results expected | June 2027 |
| Study ends | June 2027 |
| Registry record updated | June 11, 2025 |
| Trial ID | NCT05051072 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and over with unilateral essential trigeminal neuralgia who are being evaluated for potential surgical treatment.
✕Probably not a fit
Patients with neurodegenerative or inflammatory neurological conditions, those who have previously undergone surgery for trigeminal neuralgia, or individuals with contraindications to MRI will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates patients with essential trigeminal neuralgia using advanced MRI techniques, including diffusion tensor imaging (DTI) and resting state functional MRI (fMRI). The goal is to better understand the relationship between vascular conflicts and nerve damage that may not be visible with standard MRI. By incorporating these additional imaging sequences, the study aims to improve the assessment of trigeminal nerve involvement and potentially guide surgical interventions. The MRI examination will be conducted on a high-resolution 3 Tesla machine and will last approximately 45 minutes.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses and improved surgical outcomes for patients suffering from trigeminal neuralgia.
How similar studies have gone: While the use of advanced MRI techniques in assessing trigeminal neuralgia is promising, this specific approach combining DTI and resting state fMRI is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (18 years and over); * Supported in the neurosurgery department or at the assessment and treatment center for pain for unilateral essential trigeminal neuralgia with search for vasculo-nervous conflict; Exclusion Criteria: * Patient with neurodegenerative or inflammatory neurological pathology; * Patient who has already been operated on for a DMV; * Absolute contraindication to MRI * Patient benefiting from a legal protection measure; with impaired judgment skills or unable to receive information; * Pregnant or breastfeeding women
Where it's running
-
Fondation Ophtalmologique de Rothschild
Paris, France Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.