Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Assessing Trigeminal Neuralgia with Advanced MRI Techniques

Official title: Assessment in Patients With Essential Trigeminal Neuralgia of Nerve Involvement by MRI in DTI and Functional Connectivity in "Resting State"

Run by Fondation Ophtalmologique Adolphe de Rothschild · NCT05051072 · Data updated 2026-11-12

This study is testing advanced MRI techniques to see if they can help doctors understand the causes of trigeminal neuralgia better and improve treatment options for patients.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment60 (estimated)
SponsorFondation Ophtalmologique Adolphe de Rothschild
Research network
Locations1 site (Paris)
StatusRecruiting
StartedApril 27, 2022
Main results expectedJune 2027
Study endsJune 2027
Registry record updatedJune 11, 2025
Trial IDNCT05051072 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and over with unilateral essential trigeminal neuralgia who are being evaluated for potential surgical treatment.

Probably not a fit

Patients with neurodegenerative or inflammatory neurological conditions, those who have previously undergone surgery for trigeminal neuralgia, or individuals with contraindications to MRI will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates patients with essential trigeminal neuralgia using advanced MRI techniques, including diffusion tensor imaging (DTI) and resting state functional MRI (fMRI). The goal is to better understand the relationship between vascular conflicts and nerve damage that may not be visible with standard MRI. By incorporating these additional imaging sequences, the study aims to improve the assessment of trigeminal nerve involvement and potentially guide surgical interventions. The MRI examination will be conducted on a high-resolution 3 Tesla machine and will last approximately 45 minutes.

Why it matters

Potential benefit: If successful, this study could lead to more accurate diagnoses and improved surgical outcomes for patients suffering from trigeminal neuralgia.

How similar studies have gone: While the use of advanced MRI techniques in assessing trigeminal neuralgia is promising, this specific approach combining DTI and resting state fMRI is relatively novel and has not been extensively tested in prior studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adult patients (18 years and over);
* Supported in the neurosurgery department or at the assessment and treatment center for pain for unilateral essential trigeminal neuralgia with search for vasculo-nervous conflict;

Exclusion Criteria:

* Patient with neurodegenerative or inflammatory neurological pathology;
* Patient who has already been operated on for a DMV;
* Absolute contraindication to MRI
* Patient benefiting from a legal protection measure; with impaired judgment skills or unable to receive information;
* Pregnant or breastfeeding women

Where it's running

  • Fondation Ophtalmologique de Rothschild
    Paris, France
    Recruiting

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.