Study on risk factors and outcomes in patients with tricuspid regurgitation
Official title: Tricuspid RegurgitAtion rIsk modeL Study (TRAIL Study)
Run by Sun Yat-sen University · NCT06926959 · Data updated 2026-11-12
This study looks at patients with tricuspid regurgitation in the hospital to see what factors affect their health outcomes and how likely they are to face serious issues or death.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 3000 (estimated) |
| Sponsor | Sun Yat-sen University Academic / other |
| Locations | 7 sites (Guangzhou, Guangdong and 6 other locations) |
| Status | Recruiting |
| Started | June 15, 2016 |
| Main results expected | June 15, 2030 |
| Study ends | June 15, 2030 |
| Registry record updated | April 15, 2025 |
| Trial ID | NCT06926959 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 years old who have been diagnosed with tricuspid regurgitation during hospitalization.
✕Probably not a fit
Patients who are unable to provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter cohort study focuses on patients diagnosed with tricuspid regurgitation during hospitalization. It aims to evaluate prognostic risk factors associated with this condition and construct predictive models based on follow-up observations. The primary outcome is all-cause mortality, while secondary outcomes include cardiovascular events. The study will gather data from multiple hospitals to enhance the understanding of tricuspid regurgitation outcomes.
Why it matters
Potential benefit: If successful, this study could improve risk assessment and management strategies for patients with tricuspid regurgitation.
How similar studies have gone: While there have been studies on tricuspid regurgitation, this specific approach to developing a risk model is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged over 18 yrs. * Patients diagnosed with tricuspid regurgitation during hospitalization. Exclusion Criteria: * Patients unable to provide informed consent.
Where it's running
-
The First Affiliated Hospital of Sun Yat-sen Univerity
Guangzhou, Guangdong, China Recruiting -
Third Affiliated Hospital, Sun Yat-Sun University,
Guangzhou, Guangdong, China Active not recruiting -
Jieyang People's Hospital
Jieyang, Guangdong, China Active not recruiting -
Second Affiliated Hospital of Shantou University Medical College
Shantou, Guangdong, China Active not recruiting -
Eighth Affiliated Hospital, Sun Yat-Sen University
Shenzhen, Guangdong, China Active not recruiting -
Affiliated Hospital of Guangdong Medical University
Zhanjiang, Guangdong, China Active not recruiting
Show 1 more location
-
Zhongshan People's Hospital
Zhongshan, Guangdong, China Active not recruiting
Study contacts
- Study coordinator: Xiaodong Zhuang
- Email: zhuangxd3@mail.sysu.edu.cn
- Phone: +8613760755035
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
3D Echocardiography to See How CIEDs May Worsen Tricuspid Regurgitation
This study tests whether different CIEDs (leadless pacemakers, LBBaP, and conventional pacemakers) differ in causing worsening tricuspid regurgitation, using 3D heart imaging.
-
Compare leadless and left bundle branch pacemakers for heart and valve function
This study tests whether leadless pacemakers or left bundle branch area pacing better preserve heart and tricuspid valve function in adults needing a pacemaker.
-
TriClip for treating tricuspid regurgitation in Japan
This study will see if the TriClip device is safe and helps people in Japan with symptomatic severe tricuspid regurgitation when used in routine clinical care.
-
Impact of transcatheter tricuspid valve repair on kidneys, strength, and activity in older adults
This study will try catheter-based tricuspid valve repair (TEER) in older adults with severe symptomatic tricuspid regurgitation to see if kidney function, fluid overload, and physical activity improve.
-
TARGET 2.0: Cardiovalve TR replacement for tricuspid regurgitation
This study will test a percutaneously delivered Cardiovalve tricuspid replacement via the femoral vein in adults with symptomatic severe secondary tricuspid regurgitation who are high risk for open-heart surgery.
-
Pivot Extend device to treat severe tricuspid regurgitation
This trial will try the Pivot Extend device in adults with severe, symptomatic tricuspid regurgitation to see if it safely reduces valve leakage and improves symptoms.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.