Right Heart MRI to Predict Outcomes in Functional Tricuspid Regurgitation
Official title: Right Heart Cardiac Magnetic Resonance Tissue Characterization for Clinical and Therapeutic Prognostication in Functional Tricuspid Regurgitation
Funded at Weill Medical Coll of Cornell Univ · NIH-11448728 · Data updated 2026-11-12
This NIH grant aims to use advanced heart MRI to better predict who with functional tricuspid regurgitation will have worse outcomes or respond to therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $704,851 |
| NIH project number | 1R01HL183658-01A1 |
| Project ID | NIH-11448728 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with functional tricuspid regurgitation who are being considered for or undergoing treatment, and who can undergo advanced cardiac MRI.
✕Less likely to help
Patients without functional TR or who cannot safely have MRI may not benefit from this study.
What this research studies
Functional tricuspid regurgitation is common and varies in progression and treatment response. The project will apply 3D cardiac MRI to characterize right heart tissue and identify tissue-level markers linked to outcomes. By understanding fibrosis and tissue oxygenation, doctors hope to tailor therapies and improve risk stratification for patients with TR. The study is conducted at Weill Medical College of Cornell University with patient-focused imaging and follow-up.
Why it matters
Potential benefit: If successful, patients could receive more accurate prognoses and more personalized treatment plans based on heart tissue health.
How similar studies have gone: Prior work shows MRI-based tissue characterization can inform prognosis in heart disease, though application to functional TR is evolving.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Kim, Jiwon — Weill Medical Coll of Cornell Univ
- Study coordinator: Kim, Jiwon
Related research
Other NIH-funded projects on the same topics.
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Right Heart Pressure-Volume Insights to Guide Valve Repair Decisions
A new funding project is exploring a pressure-volume tool during right-heart catheterization to help doctors decide which patients with severe tricuspid regurgitation will benefit most from transcatheter valve repair.
-
3D Echocardiography to See How CIEDs May Worsen Tricuspid Regurgitation
This study tests whether different CIEDs (leadless pacemakers, LBBaP, and conventional pacemakers) differ in causing worsening tricuspid regurgitation, using 3D heart imaging.
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Compare leadless and left bundle branch pacemakers for heart and valve function
This study tests whether leadless pacemakers or left bundle branch area pacing better preserve heart and tricuspid valve function in adults needing a pacemaker.
-
TriClip for treating tricuspid regurgitation in Japan
This study will see if the TriClip device is safe and helps people in Japan with symptomatic severe tricuspid regurgitation when used in routine clinical care.
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Impact of transcatheter tricuspid valve repair on kidneys, strength, and activity in older adults
This study will try catheter-based tricuspid valve repair (TEER) in older adults with severe symptomatic tricuspid regurgitation to see if kidney function, fluid overload, and physical activity improve.
-
TARGET 2.0: Cardiovalve TR replacement for tricuspid regurgitation
This study will test a percutaneously delivered Cardiovalve tricuspid replacement via the femoral vein in adults with symptomatic severe secondary tricuspid regurgitation who are high risk for open-heart surgery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.