Condition

Pacemaker clinical trials and research

• 11Clinical trials
• 19NIH research projects
• 8Countries

Newest Pacemaker clinical trials

All recruiting trials (11)

• 3D Echocardiography to See How CIEDs May Worsen Tricuspid Regurgitation

  This study tests whether different CIEDs (leadless pacemakers, LBBaP, and conventional pacemakers) differ in causing worsening tricuspid regurgitation, using 3D heart imaging.

  Recruiting Samsung Medical Center · Seoul, Seoul · NCT07793916

• Higher pacemaker rate for people with cardiac amyloidosis

  This study will see if temporarily increasing the pacemaker rate improves heart-failure symptoms and exercise tolerance in adults with cardiac amyloidosis who already have pacemakers.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07583823

• Lead-related tricuspid valve leakage after first-time pacemaker or ICD implantation

  This project will see if a new transvenous pacemaker or ICD lead causes new or worse tricuspid valve regurgitation in people getting their first device.

  Recruiting Clinic for General and Interventional Cardiology/Angiology, Herz- und Diabeteszentrum NRW · Bad Oeynhausen, North Rhine-Westphalia · NCT07342036

• Leadless pacemaker outcomes and follow-up at University Hospital St. Pölten

  This registry will collect and analyze outcomes and complications in adults who receive leadless pacemakers at University Hospital St. Pölten to see how the devices perform over time.

  Recruiting Karl Landsteiner University of Health Sciences · Sankt Pölten, Lower Austria · NCT07246135

• Left bundle branch area pacing versus conventional right‑ventricular pacing after TAVI for atrioventricular block

  This will test whether left bundle branch area pacing works better than standard right‑ventricular pacing for people who need a pacemaker after TAVI.

  Recruiting at 6 sites Nantes University Hospital · Brest, Finistère and 6 other locations · NCT07236489

• Evaluating tricuspid regurgitation progression in pacemaker patients

  This study looks at how tricuspid regurgitation gets worse over time in patients with pacemakers to see if different types of heart pacing affect their health outcomes.

  Recruiting Qianfoshan Hospital · Jinan · NCT06922526

• Evaluating the timing of syncope and asystole during tilt table testing

  This study is testing if the timing of fainting during a tilt table test can help predict how well a pacemaker will work for people with reflex syncope.

  Recruiting Azienda Ospedaliera di Bolzano · Bolzano · NCT06356207

• Controlling heart rate in patients with atrial fibrillation using a pacemaker and ablation

  This study tests a new way to help people with atrial fibrillation and heart failure by using a pacemaker and a procedure to control their heart rate better.

  Recruiting at 12 sites London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Victoria, British Columbia and 11 other locations · NCT06299514

• Monitoring the safety and effectiveness of leadless pacemakers in France

  This study is testing if new leadless pacemakers are safe and effective for patients who need heart rhythm support, making the process easier and more comfortable for them.

  Recruiting French Cardiology Society · La Tronche · NCT06262295

• Registry of patients with pacemakers and defibrillators

  This study is creating a registry to track the experiences and health outcomes of patients getting pacemakers or defibrillators to see how they do over time.

  Recruiting University of Campania Luigi Vanvitelli · Naples, Napoli · NCT05072119

• Impact of Different Pacing Sites in Patients with Bradyarrhythmias and Heart Failure

  This study is trying to see if pacing the heart from different spots can help people with slow heartbeats and heart failure feel better and have better long-term results.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT04931550

NIH-funded research (19)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Time-dependent membrane proteins in circadian brain cells

  A research project will map how membrane proteins in brain clock neurons change over time and may reveal targets to support healthy sleep, metabolism, and behavior.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11453680

• Understanding how human heart pacemaker cells develop

  Scientists are studying how the human heart’s natural pacemaker forms, which could lead to better treatments for rhythm problems.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11388364

• Understanding how specialized heart pacemaker cells drive rhythm and dysfunction

  This NIH grant explores how distinct heart pacemaker cell subtypes contribute to normal rhythm and sinus node dysfunction, with the goal of guiding better treatments for heart rhythm problems.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11382758

• Biopacemakers for aging hearts using stem-cell pacemaker cells

  Aims to help older patients with a faulty heart rhythm by using lab-made pacemaker cells grown from patients’ own stem cells.

  NIH research University of California at Davis · Davis, United States · NIH-11374738

• Magnesium transporter and heart pacemaker: a primate model of arrhythmias

  A physician-scientist at Stanford is studying how a magnesium transporter affects the heart's natural pacemaker rhythm in primate-like models to better understand human arrhythmias.

  NIH research Stanford University · Stanford, United States · NIH-11372213

• How heart pacemakers sense stretch and speed up

  A study at the University of Washington will explore how PIEZO channels in the heart’s pacemaker help the heart beat faster when the heart experiences stretch.

  NIH research University of Washington · Seattle, United States · NIH-11369783

• Protecting the heart's natural pacemaker cells

  Researchers are looking at how the heart’s natural pacemaker cells and their supporting tissue stay protected from mechanical stress to help adults with pacemaker problems.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11308244

• mRNA-based heart pacemaker

  This project uses short-lived mRNA delivered in lipid nanoparticles to turn heart muscle cells into natural pacemakers for adults with slow heart rhythms.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11251225

• Tiny control zones in the heart's natural pacemaker and how they change with pressure

  This work looks at how small regions inside the heart's natural pacemaker respond to long-term pressure so it can help people who develop sick sinus syndrome and slow or irregular heartbeats.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11248012

• Miniaturized long-life power for leadless pacemakers

  They are developing a tiny, long-lasting battery to power leadless pacemakers so patients could have much smaller devices that may last about 20 years.

  NIH research City Labs, INC. · Miami, UNITED STATES · NIH-11193963

• How the heart's natural pacemaker adjusts to stretch

  This project explores how the heart's natural pacemaker senses and responds to changes in stretch, which helps it adjust your heart rate.

  NIH research University of Washington · Seattle, United States · NIH-11092189

• Improving the Heart's Natural Pacemaker Function

  This project explores how to create better biological pacemakers using stem cells to help older adults whose natural heart rhythm is slowing down.

  NIH research University of California at Davis · Davis, United States · NIH-11088189

• Understanding how heart pacemaker cells develop and function

  This study is looking at how heart pacemaker cells, which help control your heartbeat, develop and work properly, especially when things go wrong, to find new ways to help people with heart rhythm problems like bradycardia.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11074559

• Using mRNA to create biological pacemakers for heart rhythm control

  This study is exploring a new way to help people with bradyarrhythmia by using mRNA to turn heart cells into natural pacemaker cells, so they can create their own electrical signals instead of needing a traditional pacemaker, which can sometimes cause problems.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11027440

• Developing a small power source for leadless cardiac pacemakers

  This study is working on a new tiny power source for leadless heart pacemakers that lasts much longer than current batteries, which could make it safer and easier for younger patients to get these devices.

  NIH research City Labs, INC. · Miami, UNITED STATES · NIH-11008195

• Understanding how the heart's pacemaker adapts to changes in pressure and volume.

  This study is looking at how the heart's natural pacemaker reacts to changes in pressure and volume, which could help us understand heart problems like sick sinus syndrome and lead to better treatments for people with irregular heartbeats.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11002675

• Understanding how heart pacemaker cells maintain their structure and function

  This study is looking at how heart cells, called cardiac pacemaker cells, work and what helps them stay healthy so they can keep your heart beating properly, which is especially important for people who might need a pacemaker.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11002672

• Investigating a key enzyme that regulates bacterial metabolism

  This study is looking at how a special enzyme in bacteria helps them grow and survive, especially when they face infections or antibiotics, and it aims to learn more about how this enzyme works in both making important cell components and managing energy use.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-10866491

• A new type of battery for leadless pacemakers

  This study is working on a new type of tiny battery for leadless pacemakers that could last up to 20 years, making life easier for heart patients by reducing the need for surgeries and improving their overall quality of life.

  NIH research City Labs, INC. · Miami, UNITED STATES · NIH-10429931

Related topics

Quick answers

How many Pacemaker clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in Italy (2 trials), China (2 trials), France (2 trials), Canada (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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