Right Heart Pressure-Volume Insights to Guide Valve Repair Decisions
Official title: A Right Heart Catheter for Pressure-Volume Loop Risk Stratification for Percutaneous Valve Repair in Tricuspid Regurgitation
Funded at Bridgesource Medical Corporation · NIH-11407066 · Data updated 2026-11-12
A new funding project is exploring a pressure-volume tool during right-heart catheterization to help doctors decide which patients with severe tricuspid regurgitation will benefit most from transcatheter valve repair.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bridgesource Medical Corporation NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $320,727 |
| NIH project number | 1R43HL182792-01A1 |
| Project ID | NIH-11407066 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults with severe tricuspid regurgitation being considered for transcatheter valve repair.
✕Less likely to help
Patients who are not candidates for catheter-based interventions or who do not undergo valve repair may not benefit from this tool.
What this research studies
This project aims to use a specialized catheter-based technique to measure pressures and volumes in the right heart during valve procedures. By capturing real-time data, clinicians hope to better predict who can tolerate valve repair and who may be at higher risk for complications. The study will be developed in a controlled, phased manner over one year, focusing on translating this tool into clear clinical guidance for patient care. The goal is to reduce uncertain outcomes and improve decision-making for older patients facing transcatheter tricuspid interventions.
Why it matters
Potential benefit: If successful, patients could receive more personalized treatment decisions, potentially improving survival and quality of life after valve repair.
How similar studies have gone: Previous work shows that pressure-volume insights can help predict outcomes in valve procedures, though specific right-heart measures for TR patients are still being refined.
Where this research is happening
-
Bridgesource Medical Corporation
Austin, United States Active
Researchers
- Principal investigator: Porterfield, John E — Bridgesource Medical Corporation
- Study coordinator: Porterfield, John E
Related research
Other NIH-funded projects on the same topics.
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Right Heart MRI to Predict Outcomes in Functional Tricuspid Regurgitation
This NIH grant aims to use advanced heart MRI to better predict who with functional tricuspid regurgitation will have worse outcomes or respond to therapies.
-
3D Echocardiography to See How CIEDs May Worsen Tricuspid Regurgitation
This study tests whether different CIEDs (leadless pacemakers, LBBaP, and conventional pacemakers) differ in causing worsening tricuspid regurgitation, using 3D heart imaging.
-
Compare leadless and left bundle branch pacemakers for heart and valve function
This study tests whether leadless pacemakers or left bundle branch area pacing better preserve heart and tricuspid valve function in adults needing a pacemaker.
-
TriClip for treating tricuspid regurgitation in Japan
This study will see if the TriClip device is safe and helps people in Japan with symptomatic severe tricuspid regurgitation when used in routine clinical care.
-
Impact of transcatheter tricuspid valve repair on kidneys, strength, and activity in older adults
This study will try catheter-based tricuspid valve repair (TEER) in older adults with severe symptomatic tricuspid regurgitation to see if kidney function, fluid overload, and physical activity improve.
-
TARGET 2.0: Cardiovalve TR replacement for tricuspid regurgitation
This study will test a percutaneously delivered Cardiovalve tricuspid replacement via the femoral vein in adults with symptomatic severe secondary tricuspid regurgitation who are high risk for open-heart surgery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.