Reducing harm for smokers with mental illness using e-cigarettes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares the effectiveness of providing e-cigarettes with and without behavioral support through telehealth for smokers with serious mental illness who are not ready to quit smoking. It aims to reduce harm by examining how e-cigarettes can be used as a coping mechanism for stress and distress. Participants must be daily smokers with a history of quit attempts but currently uninterested in cessation. The study will assess self-regulation and self-efficacy as potential mechanisms for behavior change.

Why it matters

Who can join: the full rules

Diagnostic Criteria (must have one to be eligible):

* Schizophrenia
* Bipolar disorder
* Major Depressive Disorders
* Posttraumatic disorder
* Other anxiety disorders

Additional Inclusion Criteria:

* 21 years or older;
* English-speaking;
* Daily smoker (at least 10 cigarettes/day);
* At least one quit attempt in the past 5 years using evidence- based pharmacotherapy or behavioral cessation support;
* Not currently interested in quitting.

Exclusion Criteria:

* Currently residing in a nursing home;
* Current diagnosis of Asthma;
* Cognitive impairment (score \<26 on the Telephone Interview for Cognitive Status (TICS);
* Current use of e-cigarettes (\>once a week);
* Psychiatric instability (hospitalized in the past month);
* Current AND moderate to severe substance use disorder;
* Pregnant or planning to become pregnant;
* Use of any smoked products other than cigarettes;
* Current unstable medical illness making e-cigarette unsafe (e.g., recent heart attack, cancer);
* Participation in SWITCH IT pilot study.

Where it's running

• Seven Counties Services
  Louisville, Kentucky, United States Recruiting
• The Providence Center
  Providence, Rhode Island, United States Recruiting

Study contacts

• Principal investigator: Sarah I. Pratt, PhD — Dartmouth Health
• Study coordinator: Meghan M. Santos, MSW
• Email: meghan.m.santos@hitchcock.org
• Phone: 978-494-4260

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Volitional Help Sheets to Support Smoking Cessation in Clinical Care

  This pilot tests whether adding a short, personalized if-then planning tool helps people in a French clinic quit smoking when used alongside usual care.

  Recruiting Clinique de la Mitterie · Lille · NCT07910214

• Extended tobacco support for people experiencing homelessness

  This program tests whether extending tobacco treatment to 6 months with pharmacist counseling, monthly nicotine replacement deliveries, and phone wellness coaching helps adults experiencing homelessness quit smoking compared with a 3-month package.

  Recruiting Phase 4 University of California, San Francisco · San Francisco, California · NCT07148232

• Semaglutide to help people with type 2 diabetes quit smoking

  This pilot will test whether adding semaglutide to combination nicotine replacement helps adults with type 2 diabetes quit smoking and limits post-quit weight gain.

  Recruiting Phase 3 Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT07059377

• Varenicline-based approach to help Veterans who smoke see if they can reduce smoking and try to quit

  This study tests whether varenicline, plus motivational support, helps Veterans who aren’t ready to quit reduce smoking and make quit attempts.

  Recruiting at 3 sites Phase 4 VA Office of Research and Development · San Diego, California and 3 other locations · NCT06966362

• A program to help people quit smoking using CBT and mindfulness audio support

  This study is testing if combining text messages for quitting smoking with mindfulness audio support helps people stop smoking better than just using text messages alone.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou · NCT06901713

• Quitting Matters: a smoking quit program for people living with HIV

  This 6-month program will test whether a tailored smartphone app plus nicotine patches and gum helps people living with HIV quit smoking better than a standard quit app.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT06883097

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.