Condition

Thrombocytopenia clinical trials and research

• 17Clinical trials
• 34NIH research projects
• 6Countries

Newest Thrombocytopenia clinical trials

All recruiting trials (17)

• Predicting bleeding risk in patients with severe thrombocytopenia using a viscoelastic and clinical score

  We test a new score that combines viscoelastic test results with clinical data to see if we can predict bleeding risk in adults with malignant hematologic disorders and very low platelets.

  Recruiting Centre Hospitalier Annecy Genevois · Épagny, Auvergne-Rhône-Alpes · NCT07653672

• Estimating Platelet Counts with ROTEM PLTEM in Laboring Women with Low Platelets or Heavy Bleeding

  This study tests whether the PLTEM value from ROTEM sigma testing can quickly estimate platelet count in pregnant women with low platelets or severe postpartum hemorrhage to help decisions about anesthesia and transfusions.

  Recruiting Hospital General Universitario Gregorio Marañon · Madrid · NCT07616349

• Etamsylate versus placebo to prevent bleeding after stem cell transplant

  This will test whether etamsylate can reduce bleeding in adults with very low platelets after hematopoietic stem cell transplantation.

  Recruiting Phase 3 First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang · NCT07442513

• Umbilical cord blood therapy for cancer treatment–related low platelets

  This trial will try an intravenous umbilical cord blood infusion to see if it raises platelet counts in people aged 12–65 with cancer treatment–induced thrombocytopenia.

  Recruiting Phase 2 Zhejiang Cancer Hospital · Hangzhou, Zhejiang · NCT07441720

• Herombopag for low platelets caused by T‑DM1 in breast cancer

  This will test whether herombopag tablets can raise or stabilize platelet counts in breast cancer patients who developed low platelets after T‑DM1 so they can continue planned T‑DM1 cycles.

  Recruiting Phase 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07257809

• Umbilical cord blood-derived megakaryocyte injection for chemotherapy-related low platelets

  This single-dose treatment will try to raise platelet counts in adults with cancer who developed low platelets from anti-cancer therapy.

  Recruiting Phase 1 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT07110090

• Using apixaban to treat blood clots in cancer patients with low platelet counts

  This study is testing if a new dose of the blood thinner apixaban can safely help cancer patients with low platelet counts manage blood clots without causing more bleeding.

  Recruiting Early Phase 1 Beth Israel Deaconess Medical Center · Boston, Massachusetts · NCT06886516

• Using luspatercept to improve low blood cell counts in patients with clonal cytopenias of uncertain significance

  This study is testing if a drug called luspatercept can help people with low blood cell counts due to clonal cytopenias of uncertain significance feel better and improve their blood levels over 24 weeks.

  Recruiting Phase 2 Weill Medical College of Cornell University · New York, New York · NCT06788691

• Testing platelet transfusion thresholds in extremely preterm infants

  This study is testing if giving platelet transfusions at a lower level can help extremely premature babies survive without major bleeding during their first week of life.

  Recruiting at 20 sites NICHD Neonatal Research Network · Birmingham, Alabama and 19 other locations · NCT06676904

• Using lusutrombopag and thrombopoietin to treat low platelet counts in liver disease patients before surgery

  This study is testing if a combination of two medications can help increase low platelet counts in adults with liver disease before they have surgery, to reduce the need for blood transfusions.

  Recruiting at 2 sites Phase 2 Anhui Provincial Hospital · Fuyang, Anhui and 1 other locations · NCT06673498

• Using pulsatile blood flow during heart surgery to prevent kidney injury

  This study tests if using a pulsing blood flow during heart surgery can help protect the kidneys from injury better than the usual steady flow.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT06349577

• Using stem cell exosomes to help recover from chemotherapy side effects in leukemia patients

  This study is testing if giving leukemia patients special stem cell treatments can help them recover better from the side effects of chemotherapy.

  Recruiting Phase 1 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT06245746

• Treatment of thrombocytopenia in connective tissue diseases with Telitacicept

  This study is testing if a new treatment called Telitacicept can help people with low platelet counts caused by connective tissue diseases feel better.

  Recruiting at 23 sites Phase 2 Beijing Hospital · Hefei, Anhui and 22 other locations · NCT05998759

• Whole blood transfusion for children with severe malaria

  This study is testing if giving whole blood transfusions can help children aged 6 months to 15 years with severe malaria live longer compared to standard care without transfusions.

  Recruiting Johns Hopkins Bloomberg School of Public Health · Baltimore, Maryland and 1 other locations · NCT05711485

• Strategies for anticoagulation in cancer patients with low platelet counts and blood clots

  This study is testing two different ways to treat blood clots in cancer patients with low platelet counts to see which method causes fewer bleeding problems.

  Recruiting at 3 sites Phase 4 Ottawa Hospital Research Institute · Edmonton, Alberta and 3 other locations · NCT05255003

• Using zanubrutinib to treat antiphospholipid syndrome with low platelet counts

  This study is testing if zanubrutinib can help people with antiphospholipid syndrome and low platelet counts who haven't found relief with other treatments.

  Recruiting at 2 sites Phase 2 Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality and 1 other locations · NCT05199909

• Evaluating anti-platelet antibodies in diagnosing autoimmune thrombocytopenia

  This study is testing if checking for specific antibodies in the blood can help doctors diagnose immune thrombocytopenia in adults with low platelet counts.

  Recruiting University Hospital, Bordeaux · Pessac · NCT04800458

NIH-funded research (34)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• New ideas to understand, diagnose, and treat heparin-induced thrombocytopenia

  A Mayo Clinic led study will look at the different kinds of HIT antibodies to improve diagnosis and treatment for people with HIT.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-11482912

• Second-generation BLVRB inhibitors to help chemotherapy patients with low platelets

  A new drug candidate is being developed to raise platelet counts in patients whose cancer treatment lowers them, reducing bleeding risk.

  NIH research Blood Cell Technologies, LLC · Stony Brook, UNITED STATES · NIH-11457446

• Immunobiology of vaccine-related clotting after adenovirus vaccines

  This research asks how antibodies linked to a rare vaccine-related clotting condition (VITT) interact with specific blood proteins to cause clots after certain COVID-19 vaccines.

  NIH research Versiti Blood Health, INC. · Milwaukee, United States · NIH-11372209

• Understanding and diagnosing Heparin-Induced Thrombocytopenia (HIT)

  A project to understand the immune factors behind HIT and develop faster, more accurate tests to help people who need heparin therapy.

  NIH research Versiti Blood Health, INC. · Milwaukee, United States · NIH-11372204

• Fetal and neonatal platelet allergy: understanding why some babies bleed

  A study to understand why maternal antibodies cause serious bleeding in babies with FNAIT, using an animal model and human-relevant clues to improve future care for affected families.

  NIH research Versiti Blood Health, INC. · Milwaukee, United States · NIH-11372201

• Molecular mechanisms behind immune-related low platelets and clots in transfusion medicine

  This grant supports a team of researchers to understand how immune factors cause low platelets and abnormal clots, with a focus on transfusion medicine and pediatric to adult patients.

  NIH research Versiti Blood Health, INC. · Milwaukee, United States · NIH-11372196

• Animal model proof-of-concept for TAR syndrome treatment

  A researcher is testing new ways to treat TAR syndrome by using a mouse model that mimics the human bone and blood problems.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11352187

• Understanding the immune signals behind heparin-induced HIT

  This grant looks at how the body’s immune system creates antibodies that cause a dangerous reaction to heparin, aiming to improve detection and prevention for patients who need this medication.

  NIH research Versiti Blood Health, INC. · Milwaukee, United States · NIH-11332609

• How a mother's immune reaction can cause newborn low platelets (FNAIT)

  This project aims to find markers that show which pregnancies are at high risk for severe fetal or newborn low platelets (FNAIT) so affected mothers and babies can get more targeted care.

  NIH research Versiti Blood Health, INC. · Milwaukee, United States · NIH-11325309

• Faster, more accurate test for heparin-induced thrombocytopenia

  We're creating a quick lab test to find dangerous platelet reactions in people who have received heparin and might have heparin-induced thrombocytopenia (HIT).

  NIH research Emory University · Atlanta, United States · NIH-11323524

• New treatment to reduce bleeding in patients with low platelet counts

  This study is testing a new type of treatment that uses tiny particles to help people with low platelet counts, like those undergoing chemotherapy or dealing with autoimmune disorders, by providing a better way to prevent excessive bleeding.

  NIH research Haima Therapeutics, LLC · Cleveland, United States · NIH-11285688

• Understanding Blood Clotting After Certain Vaccines

  This research looks into why some people develop unusual blood clots and low platelet counts after certain COVID-19 vaccines.

  NIH research Versiti Blood Health, INC. · Milwaukee, United States · NIH-11158659

• Understanding Heparin-Induced Thrombocytopenia

  This project aims to better understand and diagnose a serious blood condition called heparin-induced thrombocytopenia, which can occur after receiving heparin medication.

  NIH research Versiti Blood Health, INC. · Milwaukee, United States · NIH-11158650

• Understanding a Bleeding Disorder in Newborns Caused by Mother's Antibodies

  This research explores why some babies develop a severe bleeding disorder called FNAIT, where a mother's antibodies reduce her baby's platelets.

  NIH research Versiti Blood Health, INC. · Milwaukee, United States · NIH-11158643

• Understanding Immune Blood Disorders Affecting Platelets

  This program explores how the immune system causes low platelet counts and blood clots in people of all ages, from newborns to adults.

  NIH research Versiti Blood Health, INC. · Milwaukee, United States · NIH-11158635

• Safer testing and treatment for heparin-induced low platelets (HIT)

  This project will develop clearer blood tests and safer treatment options for people who develop low platelets after heparin (HIT).

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11142528

• Blood type and immune genes linked to dangerous heparin reactions

  Researchers are looking at whether blood type and certain immune genes explain why some people develop a dangerous drop in platelets after heparin.

  NIH research University of Arizona · Tucson, United States · NIH-11098674

• Understanding maternal immune responses affecting newborns with low platelet counts

  This study is looking at how a mother's immune system can affect her baby's platelets, which might lead to a serious bleeding condition in newborns, and it aims to find out which pregnancies are at higher risk so that better tests and prevention methods can be developed to help keep babies safe.

  NIH research Versiti Wisconsin, INC. · Milwaukee, United States · NIH-11079524

• Developing a new treatment for immune thrombocytopenia using a specialized enzyme

  This study is testing a new treatment for people with immune thrombocytopenia (ITP) that uses a specially designed enzyme to help reduce harmful antibodies and improve platelet counts, aiming to provide a safer and more effective option than what’s currently available.

  NIH research Cyrus Biotechnology, INC. · Seattle, United States · NIH-11069861

• Developing a test to detect harmful antibodies related to Heparin-induced Thrombocytopenia

  This study is working on a new, more accurate test to help doctors find out if patients have Heparin-induced Thrombocytopenia (HIT), a serious condition that can happen when they receive heparin treatment, so that patients can get the right care without the confusion of false-positive results from current tests.

  NIH research Retham Technologies, INC. · Wauwatosa, UNITED STATES · NIH-11055939

• Understanding the immune response in patients with heparin-induced thrombocytopenia

  This study is looking at how the immune system responds to heparin, a blood thinner, to find out more about a serious condition called heparin-induced thrombocytopenia (HIT), and it aims to help doctors better identify harmful antibodies in patients, even if their regular tests come back normal, so they can prevent ser

  NIH research Versiti Wisconsin, INC. · Milwaukee, United States · NIH-11050870

• Understanding how platelet strength relates to bleeding risk in immune thrombocytopenia

  This study is looking at how strong individual platelets are in people with immune thrombocytopenic purpura (ITP) to see if that can help doctors figure out who might be at a higher risk for bleeding and need treatment, so they can avoid giving unnecessary treatment to those who are less at risk.

  NIH research Emory University · Atlanta, United States · NIH-11042700

• Better tests for diagnosing heparin-induced thrombocytopenia

  This study is working on a new way to quickly and accurately diagnose heparin-induced thrombocytopenia (HIT) in patients who are receiving heparin, so they can get the right treatment faster and stay safer.

  NIH research Emory University · Atlanta, United States · NIH-11029546

• Understanding how certain proteins affect blood clotting issues caused by heparin.

  This study is looking at how certain proteins in your blood might play a role in heparin-induced thrombocytopenia (HIT), a serious condition that can happen if you’re treated with heparin, and it aims to find out how different factors like age, sex, and ethnicity affect this condition to help improve tests and treatmen

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11010341

• How a specific mutation in the ETV6 gene affects blood cell production

  This study is looking at a gene called ETV6 that affects how our blood cells, especially platelets, are made and how a specific mutation can lead to lower platelet counts and a higher chance of blood cancers, which could help patients with ETV6 mutations understand their condition better and find new ways to manage it.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11004105

• Understanding vaccine-related blood clotting issues

  This study is looking into a rare but serious condition called vaccine-induced immune thrombotic thrombocytopenia (VITT) that can happen after getting certain COVID-19 vaccines, and it aims to understand how specific antibodies in the blood might cause this issue, so that doctors can find better ways to diagnose and tr

  NIH research Versiti Wisconsin, INC. · Milwaukee, United States · NIH-10934145

• Understanding the immune response in heparin-induced thrombocytopenia

  This study is looking to create a quick and reliable test to help doctors tell the difference between harmful and harmless antibodies in patients who have had a serious reaction to heparin, which could lead to better treatment and outcomes for those affected.

  NIH research Versiti Wisconsin, INC. · Milwaukee, United States · NIH-10934144

• Understanding a bleeding disorder in newborns caused by maternal antibodies

  This study is looking into Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT), a condition where a mother's antibodies can harm her baby's platelets, which might cause serious bleeding; researchers are using animal models to learn more about how these antibodies work so they can find better ways to diagnose and treat b

  NIH research Versiti Wisconsin, INC. · Milwaukee, United States · NIH-10934143

• Understanding how immune responses affect blood platelet levels

  This study is looking into how the immune system affects low platelet counts and blood clotting issues, with the goal of finding better treatments for people of all ages, from newborns to adults.

  NIH research Versiti Wisconsin, INC. · Milwaukee, United States · NIH-10934140

• Understanding a rare blood disorder that affects platelet production and bone development

  This study is looking at how a rare condition called TAR syndrome, which causes low platelet counts and missing bones in the arms, affects the cells that make platelets, using special lab-grown cells from patients to better understand the problem.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10914689

• Understanding and improving treatment for heparin-induced thrombocytopenia

  This study is looking at a condition called heparin-induced thrombocytopenia (HIT) to help doctors tell the difference between harmful and harmless antibodies, so they can make better treatment choices and avoid giving patients unnecessary medications that might cause more bleeding.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10901956

• Investigating how blood type and genetic factors contribute to heparin-induced thrombocytopenia

  This study is looking at how some people might have a bad reaction to heparin, a common blood thinner, and aims to find out if certain genes or immune responses can help predict who might be at risk, so doctors can better protect patients before they start treatment.

  NIH research University of Arizona · Tucson, United States · NIH-10886615

• Investigating the causes of blood platelet defects and related health issues.

  This study is looking into how certain genetic factors during early development can lead to low platelet counts and related health issues, with the hope that the findings will help improve diagnosis and treatment for patients with these conditions.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10850978

• Developing a test to detect harmful antibodies related to Heparin-induced Thrombocytopenia

  This study is working on a new, more accurate test to help doctors find out if patients have Heparin-induced Thrombocytopenia (HIT), a serious condition that can happen when they receive heparin treatment, so that patients can get the right care and feel better faster.

  NIH research Retham Technologies, INC. · Wauwatosa, UNITED STATES · NIH-10653274

Related topics

Quick answers

How many Thrombocytopenia clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in China (8 trials), United States (5 trials), France (2 trials), Spain (1 trial), Zambia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1: 2, Early Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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