Condition

Hematologic Malignancies clinical trials and research

• 33Clinical trials
• 28NIH research projects
• 46Countries

Newest Hematologic Malignancies clinical trials

All recruiting trials (33)

• Tempus Open Link registry for cancer patients using Olivia platform

  This registry tests whether Olivia can securely enroll cancer patients and combine their health data from EHRs and patient-reported outcomes to build a large, de-identified dataset.

  Recruiting Tempus AI · Chicago, Illinois · NCT07756034

• Genetics of Blood Cancers in the U.S. population

  This study tests how genetic factors relate to blood cancers by collecting saliva DNA and online health surveys from at least 10,000 U.S. adults.

  Recruiting Rutgers, The State University of New Jersey · Piscataway, New Jersey · NCT07714044

• Leflunomide to prevent CMV reactivation after haploidentical stem cell transplant

  This study tests whether leflunomide can prevent CMV reactivation in adults undergoing haploidentical hematopoietic stem cell transplantation.

  Recruiting Phase 2 Tata Memorial Centre · Navi Mumbai, Maharashtra and 2 other locations · NCT07709013

• MK-1045-006: testing a new treatment for B-cell cancers like CLL and SLL

  This trial will test MK-1045 in people with relapsed or treatment‑refractory CLL/SLL to see if it’s safe and how well it works.

  Recruiting at 8 sites Phase 2 Merck Sharp & Dohme LLC · Medellín, Antioquia and 7 other locations · NCT07709000

• Predicting bleeding risk in patients with severe thrombocytopenia using a viscoelastic and clinical score

  We test a new score that combines viscoelastic test results with clinical data to see if we can predict bleeding risk in adults with malignant hematologic disorders and very low platelets.

  Recruiting Centre Hospitalier Annecy Genevois · Épagny, Auvergne-Rhône-Alpes · NCT07653672

• Ruxolitinib to prevent graft-versus-host disease after allogeneic stem cell transplant

  This trial will test whether adding ruxolitinib to standard drugs better prevents chronic graft-versus-host disease in adults receiving an allogeneic stem cell transplant for blood cancers.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07359859

• Prophylactic TCRαβ+/CD19+- Depleted Donor Lymphocyte Infusion After Allogeneic Stem Cell Transplant in High-Risk Blood C cancers

  A safety-driven test to see if a specially prepared donor lymphocyte infusion given after an allogeneic stem cell transplant is tolerable and safe in patients with high-risk hematologic malignancies.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07285668

• BL-M24D1 in relapsed or refractory multiple myeloma and other blood cancers

  This early-phase trial tests BL-M24D1 in adults with relapsed or refractory multiple myeloma or other hematologic cancers to see if it is safe and tolerable and to get a first look at its activity.

  Recruiting Phase 1 Sichuan Baili Pharmaceutical Co., Ltd. · Chengdu, Sichuan · NCT07255898

• INCA036873 for adults with advanced solid tumors and blood cancers.

  This trial will test whether the experimental drug INCA036873 is safe and tolerable in adults with advanced or metastatic solid tumors or certain blood cancers who have already tried standard treatments.

  Recruiting at 19 sites Phase 1 Incyte Corporation · Duarte, California and 21 other locations · NCT07195916

• Digital health program for self-management and remote monitoring during outpatient CAR-T therapy

  This Phase 3 study tests whether a remote patient-monitoring and education program helps adults with relapsed or refractory blood cancers and their family caregivers manage symptoms during and after outpatient CAR-T therapy.

  Recruiting Phase 3 City of Hope Medical Center · Duarte, California · NCT07186192

• Combining donor-derived anti-CD19 CAR-T cells with haploidentical transplant using post-transplant cyclophosphamide

  This trial tests whether giving donor-derived anti-CD19 CAR-T cells together with a haploidentical bone marrow transplant using post-transplant cyclophosphamide can help adults (18–75) with high‑risk CD19+ blood cancers.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07162038

• Pralatrexate dosing and safety in adults with cancer and differing liver function

  This trial will test how pralatrexate is processed by the body and what doses are safe for adults with advanced solid tumors or blood cancers who have normal or impaired liver function.

  Recruiting at 3 sites Phase 1 Acrotech Biopharma Inc. · Cerritos, California and 3 other locations · NCT07036133

• Allogeneic stem cell transplant with low-dose post-transplant cyclophosphamide to prevent graft-versus-host disease.

  This study tests whether giving low-dose (25 mg/kg) cyclophosphamide on days +3 and +4 after allogeneic peripheral blood stem cell transplant can prevent GVHD in adults with blood cancers who receive reduced-intensity or non-myeloablative conditioning.

  Recruiting Phase 2 Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06926595

• Testing IM-1021 for advanced cancer treatment

  This study is testing a new treatment called IM-1021 to see if it can safely help people with advanced cancer feel better.

  Recruiting at 24 sites Phase 1 Immunome, Inc. · Duarte, California and 23 other locations · NCT06823167

• Optimized cord blood transplantation for high-risk blood cancer patients needing a second transplant

  This study is testing a new approach using cord blood transplants for patients with high-risk blood cancers who need a second transplant to see if it helps them live longer and have better outcomes.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT06807606

• First-in-human testing of RJK-RT2831 to find a safe dose and understand how the drug behaves in the body.

  This trial will test RJK-RT2831 in adults with relapsed or refractory hematologic malignancies to find safe doses, learn how the drug is processed in the body, and look for early signs of benefit.

  Recruiting at 16 sites Phase 1 Nanjing RegeneCore Biotech Co., Ltd. · Hefei, Anhui and 15 other locations · NCT06756451

• Treatment for lung infections in patients with certain viral infections and blood cancers

  This study is testing a new inhalation treatment called PUL-042 to see if it can help people with blood cancers or who have had stem cell transplants recover from lung infections caused by certain viruses.

  Recruiting at 11 sites Phase 2 Pulmotect, Inc. · Duarte, California and 11 other locations · NCT06665100

• Continued treatment for patients with blood cancers using tafasitamab

  This study is testing if continuing treatment with tafasitamab can help patients with blood cancers who have already seen some improvement from the medication.

  Recruiting at 3 sites Phase 2 Incyte Corporation · Győr and 4 other locations · NCT06465433

• Combining ICP-248 and Orelabrutinib for treating chronic lymphocytic leukemia

  This study is testing if combining two medications, ICP-248 and Orelabrutinib, can help people with newly diagnosed chronic lymphocytic leukemia or small lymphocytic lymphoma feel better and improve their treatment results.

  Recruiting at 44 sites Phase 2/3 Beijing InnoCare Pharma Tech Co., Ltd. · Bengbu, Anhui and 52 other locations · NCT06378138

• Evaluating a decision support tool for patients with blood cancers

  This study tests a new tool called PRIME to see if it helps older adults with blood cancers make treatment choices that better match their personal preferences compared to regular care.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06296368

• Personalized conditioning regimen for stem cell transplantation

  This study is testing a personalized treatment plan for stem cell transplants in people with blood cancers to see if adjusting the doses of certain medications can improve their outcomes.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT06028828

• Using immunoglobulin therapy to prevent infections after CAR-T cell treatment

  This study is testing if giving extra antibodies through immunoglobulin therapy can help prevent infections in patients receiving CAR-T cell treatment for blood cancers.

  Recruiting at 7 sites Phase 2 Fred Hutchinson Cancer Center · Duarte, California and 6 other locations · NCT05952804

• Using cyclophosphamide for older patients after stem cell transplant

  This study is testing the best dose of cyclophosphamide for older patients receiving a specific type of stem cell transplant to see how it affects their recovery and health.

  Recruiting Phase 1 Cedars-Sinai Medical Center · Los Angeles, California · NCT05849207

• Observing heart rhythms in patients treated with BTK inhibitors or venetoclax

  This study is testing how Bruton’s tyrosine kinase inhibitors affect heart rhythms in people with chronic lymphocytic leukemia and comparing it to those taking venetoclax to see if there are any risks.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05724121

• New treatment approach for HIV patients with blood cancers using bone marrow transplantation

  This study is testing a new combination of drugs to see if it can safely help HIV patients with blood cancers who need a bone marrow transplant, while also preventing complications from the transplant.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05470491

• Evaluating the effects of nemtabrutinib in patients with blood cancers

  This study is testing a new oral medication called nemtabrutinib to see if it can help people with blood cancers like chronic lymphocytic leukemia and Waldenström's macroglobulinemia feel better and stay safe.

  Recruiting at 94 sites Phase 2 Merck Sharp & Dohme LLC · Springdale, Arkansas and 120 other locations · NCT04728893

• Testing a new drug for blood cancers

  This study is testing a new drug called SLS009 to see if it can safely help people with tough-to-treat blood cancers like acute myeloid leukemia and lymphoma.

  Recruiting at 12 sites Phase 1/2 Sellas Life Sciences Group · Birmingham, Alabama and 31 other locations · NCT04588922

• Abnormal CD56 expression in hematologic cancers

  This project will test if CD56 is abnormally expressed across different blood cancers in newly diagnosed patients.

  Recruiting Assiut University · Asyut and 1 other locations · NCT04546945

• Register of patients undergoing blood stem cell transplantation

  This study is tracking patients who have had blood stem cell transplants for blood cancers to see how well they do and what complications they might face.

  Recruiting Technical University of Munich · Munich · NCT04263857

• Long-term evaluation of pembrolizumab for patients with advanced tumors

  This study is testing how well pembrolizumab works and how safe it is for people with advanced tumors who have already been part of previous studies.

  Recruiting at 472 sites Phase 3 Merck Sharp & Dohme LLC · Tucson, Arizona and 781 other locations · NCT03486873

• Assessment of elderly cancer patients' needs

  This study looks at how to better support older cancer patients by checking their overall health and needs to help doctors create the best treatment plans for them.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil · NCT02884375

• Mayo Clinic radiotherapy outcomes registry and biobank

  This project collects blood and tissue from people with solid tumors or blood cancers treated with photon or proton radiotherapy at Mayo Clinic Rochester to see if biological markers link to side effects and outcomes.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT02457962

• Access and distribution of unlicensed cryopreserved cord blood units

  This study is testing how well unlicensed frozen cord blood units work for helping both kids and adults with blood cancers recover after a transplant.

  Recruiting at 113 sites Center for International Blood and Marrow Transplant Research · Birmingham, Alabama and 141 other locations · NCT01351545

NIH-funded research (28)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Adapting flow cytometry to detect childhood leukemias in Kenya using a single-test screen

  A low-cost, blood-based flow cytometry screen in Kenya aims to detect and triage suspected leukemias in children and young adults.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11622490

• Understanding why patients with blood cancers start and stick with oral cancer medicines

  A study to learn what helps or hinders Black patients with blood cancers in starting and continuing their prescribed oral cancer medicines.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11611692

• Why some blood cancer cells survive after treatment by resisting natural killer cells

  This work is trying to understand why leftover blood cancer cells in leukemia and multiple myeloma survive treatment by escaping natural killer immune cells.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11473571

• Expanding blood cancer care and research to Brooklyn and Queens

  Aimed at bringing more blood cancer care and clinical trials to Brooklyn and Queens to help a diverse patient community.

  NIH research New York University School of Medicine · New York, United States · NIH-11471239

• Adapting flow cytometry to detect blood cancers in Kenyan children and young people

  A nationwide Kenyan effort will test a cheaper, single-blood-sample screening method using flow cytometry to screen for leukemia in kids and young adults who may have the disease.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11416488

• Next-gen genetic engineering of CD45 to boost CAR-T therapy for blood cancers

  A research team is developing a way to make CAR-T cells work for many blood cancers by re-engineering a common blood cell protein called CD45.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11413787

• Single-tube blood test to detect acute blood cancers in Kenyan children and young adults

  A simple, low-cost blood test aims to find leukemia early in Kenyan children and young adults so fewer people need painful bone marrow procedures and long travel.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11398832

• Palliative care support for patients getting CAR T therapy for blood cancers

  A clinician-led program designed to improve quality of life and ease the burden on patients and caregivers during and after CAR T cell therapy for blood cancers.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11385006

• PHF6 mutation linked leukemia mechanisms explained

  Researchers are studying how PHF6 mutations drive blood cancers to identify better ways to treat them.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11333545

• Exercise as an Immune Boost for gd T-cell Therapies in Blood Cancers

  A doctor-research team is studying whether exercise can boost a special kind of immune cell to fight blood cancers like ALL and NHL.

  NIH research University of Arizona · Tucson, United States · NIH-11313816

• Atrial fibrillation in cancer patients treated with BTK inhibitors

  This project looks at how often and how badly atrial fibrillation happens in people with blood cancers who are taking Bruton’s tyrosine kinase inhibitors, and how to predict and manage it.

  NIH research Stanford University · Stanford, United States · NIH-11296763

• DNMT3A's role in blood cancers

  This project looks at how changes in the DNMT3A gene help cause leukemias like AML, with the goal of improving prevention and treatment for people with blood cancers.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11237988

• Why some blood cancer cells resist natural killer immune cells

  Researchers are finding how leukemia and myeloma cells survive treatment by resisting natural killer immune cells so future therapies can better prevent relapse in people with blood cancers.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11237081

• Making CD45 a single CAR‑T target for many blood cancers

  This project alters immune cells so CD45 can be safely targeted, aiming to create one CAR‑T approach that could treat multiple blood cancers.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11192827

• Monitoring COVID-19 immune responses in patients with blood cancers

  This study looks at how well COVID-19 vaccines work in people with blood cancers or autoimmune diseases compared to healthy individuals, using skin samples and blood tests to better understand their immune responses, which could lead to more personalized treatments and vaccines for those with these conditions.

  NIH research Yale University · New Haven, United States · NIH-11160167

• What helps people with blood cancers start and keep taking oral cancer medicines

  This project looks at why people with blood cancers (like CLL, CML, and multiple myeloma) do or don't start and stick with prescribed oral cancer medicines.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11136393

• Improving flow cytometry blood testing for early leukemia detection in Kenya

  A simpler, less invasive blood test to find leukemia in children and young adults in Kenya.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11129887

• Understanding and Treating Blood Cancers

  This program aims to better understand blood cancers like leukemia and lymphoma to find new ways to diagnose and treat them.

  NIH research Stanford University · Stanford, United States · NIH-11099849

• Improving hospice care for patients with blood cancers

  This study is working to improve hospice care for adults with blood cancers by creating a new program that allows them to get important blood transfusions at home, so they can enjoy better end-of-life care in a comfortable and familiar setting.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11089554

• Understanding and Treating Blood Cancers and Bone Marrow Transplants

  This program helps us learn more about blood cancers and related conditions, and find better ways to treat them, especially through bone marrow transplants.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11086178

• Using exercise to enhance immune cell therapies for blood cancers

  This study is looking at how exercise might help boost a special cancer treatment for patients with blood cancers like leukemia and lymphoma, especially those who have had a relapse after a stem cell transplant.

  NIH research University of Arizona · Tucson, United States · NIH-11076207

• Understanding how some cancer cells survive treatment in blood cancers

  This study is looking into why some cancer cells in blood cancers, like acute myeloid leukemia, stick around even after treatment, which can cause patients to relapse, and it aims to find new ways to target these stubborn cells by understanding how they interact with the immune system.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11003354

• Understanding why patients with blood cancers may not take their oral cancer medications as prescribed

  This study is looking at what helps or hinders patients with blood cancers, like multiple myeloma and chronic lymphocytic leukemia, from starting and sticking to their oral cancer medications, so we can find better ways to support them and improve their health and quality of life.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10942408

• Improving blood tests for early detection of blood cancers in children in Kenya

  This study is working to make it easier and cheaper for kids and young adults in Kenya to get tested for leukemia and lymphoma by using a simpler blood test that can be done right where they are, so they don’t have to travel far for expensive tests.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-10883207

• New tests to monitor COVID-19 in patients with blood cancers

  This study is looking at new ways to check how well the immune system is responding to COVID-19 in patients with blood cancers, helping doctors understand their condition better and improve their treatment.

  NIH research Yale University · New Haven, United States · NIH-10855033

• Developing personalized treatments for B-cell cancers using aptamers.

  This study is exploring a new way to create personalized treatments for patients with certain blood cancers by finding special markers on their cancer cells, using a clever tool to develop tiny DNA or RNA strands that can target these markers, which could lead to better and faster ways to diagnose and treat their condi

  NIH research Columbia Univ New York Morningside · New York, United States · NIH-10834040

• Understanding how palliative care can help patients with blood cancers receiving advanced cell therapies

  This study is looking to make life better for patients with blood cancers who are getting CAR T-cell therapy by testing a new supportive care program called PEACE, which aims to help manage their symptoms and improve their overall experience, especially towards the end of life.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10807436

• New tests to monitor COVID-19 in patients with blood cancers

  This study is looking to create new blood tests that can help doctors keep an eye on how COVID-19 affects patients with blood cancers, so they can better understand their immune responses and improve care for those at higher risk.

  NIH research Yale University · New Haven, United States · NIH-10680624

Related topics

Quick answers

How many Hematologic Malignancies clinical trials are recruiting right now?

33, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 46 countries. The most sites are in United States (22 trials), China (6 trials), France (5 trials), Denmark (4 trials), Italy (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 10, Phase 1: 7, Phase 1/2: 2, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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