Understanding how immune responses affect blood platelet levels
Official title: Molecular Mechanisms of Immune Thrombocytopenia in Transfusion Medicine
Funded at Versiti Wisconsin, INC. · NIH-10934140 · Data updated 2026-11-12
This study is looking into how the immune system affects low platelet counts and blood clotting issues, with the goal of finding better treatments for people of all ages, from newborns to adults.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Wisconsin, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,577,453 |
| NIH project number | 1P01HL167668-01A1 |
| Project ID | NIH-10934140 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with immune-mediated thrombocytopenia or related thrombotic disorders, spanning from newborns to adults.
✕Less likely to help
Patients with non-immune related causes of low platelet counts or those without any blood disorders may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind immune-mediated conditions that lead to low platelet counts and blood clotting disorders. It involves a collaborative effort between experts in platelet immunology and B cell biology, focusing on how these immune responses can impact patients of all ages, including newborns and adults. The research aims to uncover the underlying causes of these conditions to improve treatment options and patient outcomes in transfusion medicine.
Why it matters
Potential benefit: If successful, this research could lead to better management and treatment strategies for patients suffering from immune-related blood disorders.
How similar studies have gone: Previous research in platelet immunology and related fields has shown promise in understanding and treating similar conditions, indicating a strong foundation for this investigation.
Where this research is happening
-
Versiti Wisconsin, INC.
Milwaukee, United States Active
Researchers
- Principal investigator: Newman, Peter J — Versiti Wisconsin, INC.
- Study coordinator: Newman, Peter J
Related research
Other NIH-funded projects on the same topics.
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Molecular mechanisms behind immune-related low platelets and clots in transfusion medicine
This grant supports a team of researchers to understand how immune factors cause low platelets and abnormal clots, with a focus on transfusion medicine and pediatric to adult patients.
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Understanding Immune Blood Disorders Affecting Platelets
This program explores how the immune system causes low platelet counts and blood clots in people of all ages, from newborns to adults.
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Developing a new treatment for immune thrombocytopenia using a specialized enzyme
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Understanding how platelet strength relates to bleeding risk in immune thrombocytopenia
This study is looking at how strong individual platelets are in people with immune thrombocytopenic purpura (ITP) to see if that can help doctors figure out who might be at a higher risk for bleeding and need treatment, so they can avoid giving unnecessary treatment to those who are less at risk.
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A Mayo Clinic led study will look at the different kinds of HIT antibodies to improve diagnosis and treatment for people with HIT.
-
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A new drug candidate is being developed to raise platelet counts in patients whose cancer treatment lowers them, reducing bleeding risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.