Understanding a bleeding disorder in newborns caused by maternal antibodies
The Immunobiology of Fetal/Neonatal Alloimmune Thrombocytopenia
This study is looking into Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT), a condition where a mother's antibodies can harm her baby's platelets, which might cause serious bleeding; researchers are using animal models to learn more about how these antibodies work so they can find better ways to diagnose and treat babies who are affected.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Wisconsin, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10934143 on NIH RePORTER |
What this research studies
This research investigates Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT), a condition where maternal antibodies attack the platelets of a fetus or newborn, potentially leading to severe bleeding complications. The study aims to explore the mechanisms behind this disorder using a preclinical animal model to better understand how specific maternal antibodies affect platelet function and contribute to the severity of the condition. By identifying the characteristics of these antibodies, researchers hope to improve diagnosis and treatment options for affected infants.
Who could benefit from this research
Good fit: Ideal candidates for this research include newborns diagnosed with FNAIT, particularly those with severe cases that may lead to major organ bleeds.
Not a fit: Patients who are not newborns or those who do not have FNAIT or related bleeding disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management and treatment strategies for newborns suffering from FNAIT, reducing the risk of severe bleeding and associated complications.
How similar studies have performed: Previous research has shown promising results in understanding similar alloimmune conditions, suggesting that this approach may yield valuable insights into FNAIT.
Where this research is happening
Milwaukee, United States
- Versiti Wisconsin, INC. — Milwaukee, United States (Active)
Researchers
- Principal investigator: Newman, Peter J — Versiti Wisconsin, INC.
- Study coordinator: Newman, Peter J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.