Understanding vaccine-related blood clotting issues
Official title: The Immunobiology of Vaccine-induced Immune Thrombotic Thrombocytopenia
Funded at Versiti Wisconsin, INC. · NIH-10934145 · Data updated 2026-11-12
This study is looking into a rare but serious condition called vaccine-induced immune thrombotic thrombocytopenia (VITT) that can happen after getting certain COVID-19 vaccines, and it aims to understand how specific antibodies in the blood might cause this issue, so that doctors can find better ways to diagnose and treat it for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Wisconsin, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $650,240 |
| NIH project number | 1P01HL167668-01A1 |
| Project ID | NIH-10934145 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced vaccine-induced immune thrombotic thrombocytopenia or related blood clotting disorders.
✕Less likely to help
Patients who have not received adenoviral COVID-19 vaccines or do not have a history of blood clotting disorders may not benefit from this research.
What this research studies
This research investigates vaccine-induced immune thrombotic thrombocytopenia (VITT), a rare but serious complication associated with adenoviral COVID-19 vaccines. The study focuses on how antibodies against specific proteins in the blood can lead to this condition, potentially causing blood clots. By examining the interactions between these antibodies and proteins, the researchers aim to identify the mechanisms behind VITT and develop better diagnostic and treatment strategies. Patients may benefit from improved understanding and management of vaccine-related complications.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for patients experiencing vaccine-related blood clotting issues.
How similar studies have gone: While the specific mechanisms of VITT are still being explored, related research on vaccine-induced immune responses has shown promise in understanding similar complications.
Where this research is happening
-
Versiti Wisconsin, INC.
Milwaukee, United States Active
Researchers
- Principal investigator: Poncz, Mortimer — Versiti Wisconsin, INC.
- Study coordinator: Poncz, Mortimer
Related research
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Immunobiology of vaccine-related clotting after adenovirus vaccines
This research asks how antibodies linked to a rare vaccine-related clotting condition (VITT) interact with specific blood proteins to cause clots after certain COVID-19 vaccines.
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Molecular mechanisms behind immune-related low platelets and clots in transfusion medicine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.