Understanding Blood Clotting After Certain Vaccines
The Immunobiology of Vaccine-induced Immune Thrombotic Thrombocytopenia
['FUNDING_P01'] · VERSITI BLOOD HEALTH, INC. · NIH-11158659
This research looks into why some people develop unusual blood clots and low platelet counts after certain COVID-19 vaccines.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VERSITI BLOOD HEALTH, INC. (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-11158659 on ClinicalTrials.gov |
What this research studies
Our bodies sometimes make special proteins called antibodies that can react unexpectedly after certain vaccines, leading to a condition called VITT where blood clots form and platelet counts drop. We believe that specific proteins in the blood, called PF4 and PBP, might play a role in starting this condition and causing the clots. We are working to identify exactly which parts of these proteins the antibodies target and how these reactions lead to clotting. This work uses both human samples and laboratory models to understand these complex immune responses.
Who could benefit from this research
Good fit: Patients who have experienced or are at risk for vaccine-induced immune thrombotic thrombocytopenia (VITT) could potentially benefit from future treatments developed from this research.
Not a fit: Patients without a history or risk of VITT would not directly benefit from this specific research focus.
Why it matters
Potential benefit: This work could lead to a better understanding of VITT, potentially helping to develop new ways to prevent or treat this rare but serious condition.
How similar studies have performed: Similar antibody-related clotting disorders, like heparin-induced thrombocytopenia (HIT), have been studied, providing a foundation for this novel investigation into VITT.
Where this research is happening
MILWAUKEE, UNITED STATES
- VERSITI BLOOD HEALTH, INC. — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PONCZ, MORTIMER — VERSITI BLOOD HEALTH, INC.
- Study coordinator: PONCZ, MORTIMER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.