Molecular mechanisms behind immune-related low platelets and clots in transfusion medicine
Official title: Molecular Mechanisms of Immune Thrombocytopenia in Transfusion Medicine
Funded at Versiti Blood Health, INC. · NIH-11372196 · Data updated 2026-11-12
This grant supports a team of researchers to understand how immune factors cause low platelets and abnormal clots, with a focus on transfusion medicine and pediatric to adult patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Blood Health, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $2,490,709 |
| NIH project number | 5P01HL167668-03 |
| Project ID | NIH-11372196 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with immune-mediated thrombocytopenia or related transfusion-associated platelet disorders, across fetal, neonatal, pediatric, and adult populations.
✕Less likely to help
Some patients with non-immune platelet disorders or unrelated conditions may not benefit from this program.
What this research studies
Researchers at Versiti Blood Research Institute and Children’s Hospital of Philadelphia will work together to uncover how specific antibodies and immune cells trigger platelet loss and thrombosis. The project uses a multi-project approach to study platelet immunology, activation, and B cell biology, aiming to translate findings from the lab to clinical settings. The work involves studying immune insults in fetus, newborn, and adult patients to prevent and treat immune-mediated platelet disorders.
Why it matters
Potential benefit: If successful, patients could experience fewer immune-related platelet problems and related bleeding or clotting complications.
How similar studies have gone: Previous work in platelet immunology and B cell interactions has shown promise in identifying immune pathways involved in thrombocytopenia and thrombosis.
Where this research is happening
-
Versiti Blood Health, INC.
Milwaukee, United States Active
Researchers
- Principal investigator: Newman, Peter J — Versiti Blood Health, INC.
- Study coordinator: Newman, Peter J
Related research
Other NIH-funded projects on the same topics.
-
Understanding Immune Blood Disorders Affecting Platelets
This program explores how the immune system causes low platelet counts and blood clots in people of all ages, from newborns to adults.
-
Developing a new treatment for immune thrombocytopenia using a specialized enzyme
This study is testing a new treatment for people with immune thrombocytopenia (ITP) that uses a specially designed enzyme to help reduce harmful antibodies and improve platelet counts, aiming to provide a safer and more effective option than what’s currently available.
-
Understanding how platelet strength relates to bleeding risk in immune thrombocytopenia
This study is looking at how strong individual platelets are in people with immune thrombocytopenic purpura (ITP) to see if that can help doctors figure out who might be at a higher risk for bleeding and need treatment, so they can avoid giving unnecessary treatment to those who are less at risk.
-
Understanding how immune responses affect blood platelet levels
This study is looking into how the immune system affects low platelet counts and blood clotting issues, with the goal of finding better treatments for people of all ages, from newborns to adults.
-
New ideas to understand, diagnose, and treat heparin-induced thrombocytopenia
A Mayo Clinic led study will look at the different kinds of HIT antibodies to improve diagnosis and treatment for people with HIT.
-
Second-generation BLVRB inhibitors to help chemotherapy patients with low platelets
A new drug candidate is being developed to raise platelet counts in patients whose cancer treatment lowers them, reducing bleeding risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.