Condition

TBI (Traumatic Brain Injury) clinical trials and research

• 26Clinical trials
• 1New in 30 days
• 5Countries

Newest TBI (Traumatic Brain Injury) clinical trials

All recruiting trials (26)

• ReVIVE for mTBI: Using VR and therapy to help adults with mild traumatic brain injury

  This study tests a virtual reality therapy combined with standard psychotherapy to see if it can reduce PTSD symptoms and improve executive function in adults with mild traumatic brain injury.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT07890337

• Fibrinogen-to-Albumin Ratio as a Predictor of ARDS in Traumatic Brain Injury

  This study tests whether the fibrinogen-to-albumin ratio can predict who among adults with traumatic brain injury will develop acute respiratory distress syndrome (ARDS).

  Recruiting Tanta University · Tanta, Gharbia Governorate · NCT07664358

• Support-TBI: Testing a partner-based program to help people with traumatic brain injury stay connected

  A small pilot test will see if a partnered person with TBI and a close supporter can successfully participate in a 12-week program to improve social support and daily life participation.

  Recruiting Phase 1 Washington University School of Medicine · St Louis, Missouri · NCT07625098

• ENGAGE-TBI: A Feasibility Program to Reduce Social Isolation for Adults with Traumatic Brain Injury

  We’re testing a 12-session group program to help adults with traumatic brain injury in the community build social participation and reduce isolation.

  Recruiting Phase 1 Washington University School of Medicine · St Louis, Missouri · NCT07549997

• Can a bedside brain scan (fNIRS) detect activity in healthy people and in people with disorders of consciousness

  This observational study tests whether functional near-infrared spectroscopy (fNIRS) can measure brain activity at the bedside in healthy adults and in patients with disorders of consciousness in the Neuro-ICU.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT07485361

• Long-lasting effects of hyperbaric oxygen therapy on thinking after traumatic brain injury

  This project will see if people with traumatic brain injury who completed a course of hyperbaric oxygen therapy 1–4 years ago still have improved thinking and memory.

  Recruiting Assaf-Harofeh Medical Center · Zrifin · NCT07430150

• Augmented kidney clearance in neurocritical care

  This project will test whether adults in the neuro-ICU with severe brain injury, stroke, seizures, or brain infections have faster kidney clearance (ARC) that can lower antiseizure and antibiotic drug levels.

  Recruiting at 3 sites University of Alberta · Lexington, Kentucky and 2 other locations · NCT07410624

• i-STAT Alinity whole-blood test for adults with head injury in the emergency department

  This project will try the i-STAT Alinity whole-blood test in adults with recent mild head injuries (GCS 13–15) to see if it helps decide who needs a head CT.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07373509

• Early continuous hypertonic saline infusion to improve 6-month neurological outcome after traumatic brain injury

  This trial will test whether giving a continuous intravenous infusion of hypertonic saline early after traumatic brain injury helps people survive and regain independence in daily life at 6 months.

  Recruiting at 10 sites Phase 3 Nantes University Hospital · Angers and 22 other locations · NCT07319208

• Hyperbaric oxygen for thinking, mental health, and quality of life in veterans

  This trial will try hyperbaric oxygen therapy to see if it improves thinking, PTSD symptoms, mood, anxiety, and overall quality of life in veterans with mild TBI or related conditions.

  Recruiting Phase 2 Summit Hyperbarics and Wellness · Boise, Idaho · NCT07214415

• Decision-making fatigue after a traumatic brain injury

  This project will try two short computer tasks (COGED and the Restless Bandit) to see if they can detect decision-making fatigue in adults with mild to moderate traumatic brain injury and in healthy adults.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07103200

• Cognitive Behavioral Therapy for Insomnia in Active-Duty Sailors with TBI

  This study is testing whether Cognitive Behavioral Therapy for Insomnia can help active-duty sailors with a history of traumatic brain injury sleep better, comparing traditional in-person sessions to a digital version.

  Recruiting Noctem, LLC · San Diego, California · NCT06867666

• Virtual cognitive rehabilitation program for refugees with traumatic brain injury

  This trial will test whether a trauma-informed, paraprofessional-led virtual program can help English- and Spanish-speaking refugees and asylum seekers (ages 18–65) who have had mild-to-moderate TBI and are experiencing memory or thinking problems.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06839079

• Evaluating the effects of beta blockers on outcomes in traumatic brain injury patients

  This study is testing whether beta blockers can help improve recovery for people with moderate to severe traumatic brain injuries.

  Recruiting Phase 1/2 Mansoura University · Zagazig and 1 other locations · NCT06836856

• Deep Brain Stimulation for cognitive issues after brain injury

  This study is testing whether Deep Brain Stimulation can help improve memory and thinking skills in people who have cognitive issues after a traumatic brain injury that haven't gotten better with other treatments.

  Recruiting Phase 1 Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT06818864

• Mindfulness meditation for improving cognition in older adults

  This study is testing whether mindfulness meditation can help older adults, including those with mild cognitive impairment, improve their thinking, memory, and overall quality of life.

  Recruiting VA Boston Healthcare System · Boston, Massachusetts · NCT06792877

• Understanding brain function and cognitive outcomes after traumatic brain injury

  This study is trying to see how blood flow and brain health after a serious head injury affect thinking and memory recovery one year later for those who have had a moderate to severe traumatic brain injury.

  Recruiting at 3 sites University of Texas Southwestern Medical Center · Dallas, Texas and 2 other locations · NCT06480838

• Noninvasive ear-surface nerve stimulation for adults with traumatic brain injury in the ICU

  This pilot tests whether brief, noninvasive ear-surface nerve stimulation is safe and changes inflammation markers in adults with moderate-to-severe traumatic brain injury in the ICU.

  Recruiting at 2 sites University of Texas Southwestern Medical Center · Dallas, Texas and 1 other locations · NCT06467708

• Understanding how different anesthetics affect brain blood flow and oxygen levels during MRI

  This study is testing how different types of anesthesia affect blood flow and oxygen levels in the brain during MRI scans in kids and teens.

  Recruiting Children's Hospital Los Angeles · Los Angeles, California · NCT06195345

• Examining brain development in young children after mild traumatic brain injury

  This study is trying to see how mild concussions affect the brains and behavior of young children aged 3 to 5 compared to kids with other types of injuries.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Rennes · NCT06024122

• Telehealth exercise program to treat depression after brain injury

  This study tests whether a telehealth exercise program can help people with depression after a brain injury feel better by encouraging them to be more active.

  Recruiting University of Washington · Seattle, Washington · NCT06005194

• Evaluating well-being interventions for adults with traumatic brain injury

  This study tests two programs to see if they can help adults with moderate to severe traumatic brain injury feel better by focusing on their personal strengths.

  Recruiting Kessler Foundation · East Hanover, New Jersey · NCT05943756

• Using electrical stimulation to improve cognitive function after traumatic brain injury

  This study is testing if a type of electrical stimulation can help adults recovering from mild to moderate brain injuries think better and make decisions more easily.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT05327829

• Detecting brain activity changes after traumatic brain injury

  This study is testing a new way to monitor brain activity in patients with traumatic brain injury to see if it can help improve their diagnosis and treatment.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05205174

• Combining brain stimulation and therapy for headaches after mild brain injuries

  This study is testing if combining brain stimulation with therapy can help veterans and active military personnel manage headaches caused by mild brain injuries.

  Recruiting Veterans Medical Research Foundation · San Diego, California · NCT05176392

• Cognitive training for improving mental health in forensic patients

  This study is testing if a special brain training program can help improve thinking skills and mental health for people in a secure facility.

  Recruiting The Royal Ottawa Mental Health Centre · Ottawa, Ontario · NCT04610697

Related topics

Quick answers

How many TBI (Traumatic Brain Injury) clinical trials are recruiting right now?

26, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (19 trials), Canada (3 trials), France (2 trials), Egypt (2 trials), Israel (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 4, Early Phase 1: 1, Phase 3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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