Long-lasting effects of hyperbaric oxygen therapy on thinking after traumatic brain injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will identify adults with prior traumatic brain injury who completed a 60-session hyperbaric oxygen course at the Sagol Center between 2017 and 2021 and invite them for follow-up cognitive testing. Participants who agree will sign informed consent and undergo a computerized Neurotrax cognitive evaluation at the Sagol Center. The goal is to measure cognitive performance 1–4 years after treatment to determine whether previously reported benefits persist long-term. Patients with intervening head injuries, neurodegenerative disease, major psychiatric disorders, active malignancy, or chronic cognition-impairing medications are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Diagnosed with traumatic brain injury
2. Age 18 years or older at treatment
3. Completed a 60 session hyperbaric treatment course at the Sagol Center for Hyperbaric Medicine and Research, Shamir Medical Center (Assaf Harofeh), and performed a neurocognitive evaluation by the computerized test Neurotrax.
4. Willing and able to sign an informed consent. -

Exclusion Criteria:

1. An inability to perform a neurocognitive computerized test.
2. Any head trauma, neurodegenerative diseases or CVA after hyperbaric treatment completion.
3. Diagnosis of a psychiatric disorder including: major depression, schizophrenia, bipolar disorder
4. Active malignancy
5. Chronic use of medications that may compromise cognitive function

Where it's running

• The Sagol Center for Hyperbaric Medicine and Research Shamir Medical Center (Assaf Harofeh)
  Zrifin, Israel Recruiting

Study contacts

• Principal investigator: Shai Efrati, MD — Asaf-Harofhe MC
• Study coordinator: Shai Efrati, MD
• Email: efratishai@outlook.com
• Phone: 972549212866

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.