Understanding how different anesthetics affect brain blood flow and oxygen levels during MRI
Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)
This study is testing how different types of anesthesia affect blood flow and oxygen levels in the brain during MRI scans in kids and teens.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 1 Minute to 18 Years |
| Sex | All |
| Sponsor | Children's Hospital Los Angeles Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Trial ID | NCT06195345 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the differences in cerebral blood flow and oxygen metabolism influenced by various types of anesthesia in patients requiring clinical MRI. Eligible participants, aged from birth to 18 years, will undergo an extended MRI procedure to gather additional data on cerebral hemodynamics. The study will ensure that all standard anesthesia safety protocols are maintained throughout the process. Informed consent will be obtained from all participants before their involvement in the study.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged between birth and 18 years who are scheduled for a clinically indicated MRI and can tolerate the procedure.
Not a fit: Patients with MRI-incompatible devices, those unable to tolerate the MRI environment, preterm infants less than 25 weeks, or those clinically unstable for an extended MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of anesthesia's impact on brain function, potentially leading to improved anesthetic practices for pediatric patients.
How similar studies have performed: While this approach is observational and builds on existing knowledge, similar studies have shown promise in understanding the effects of anesthesia on cerebral hemodynamics.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals who are able to tolerate an MRI. * Are patients scheduled for a clinically indicated MRI. * Between birth and up to 18 years. Exclusion Criteria: * Presence of an MRI-incompatible device or implant (e.g. pacemakers, stents) * Unable to tolerate the enclosed spaces and loud noises for the duration of time in scanner required to obtain an MRI. * Preterm infants less than 25 weeks * Any patient who is clinically too unstable to extend their MRI by up-to 7.5 minutes.
Where this trial is running
Los Angeles, California
- Children's Hospital Los Angeles — Los Angeles, California, United States (Recruiting)
Study contacts
- Principal investigator: Matthew Borzage, PhD — Children's Hospital Los Angeles
- Study coordinator: Hannah E Wiseman, MPH
- Email: hwiseman@chla.usc.edu
- Phone: 323-361-3963
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.