ReVIVE for mTBI: Using VR and therapy to help adults with mild traumatic brain injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 1 trial investigates an integrated treatment that blends virtual reality exposure with standard psychotherapy for adults who have mild traumatic brain injury and PTSD symptoms. Participants will receive VR-based interventions alongside ongoing psychotherapeutic care to target hyperarousal and hypervigilance. The study uses the Davidson Trauma Scale to measure changes in PTSD symptoms, particularly hyperarousal. Recruitment is limited to adults with a history of concussion and current PTSD symptoms, who are receiving or have recently received evidence-based treatments. The research is conducted at Johns Hopkins Bayview Medical Center in Baltimore, under Johns Hopkins University as lead sponsor.

Why it matters

Who can join: the full rules

Inclusion criteria:

* History of one or more concussions.
* Presence of mild-to-moderate PTSD symptoms, defined as a score between 20 and 44 on the Davidson Trauma Scale (DTS), indicating clinically relevant but not severe symptomatology (Davidson et al., 1997).
* Prior or ongoing therapy, defined as current or recent (within the last 3 months) engagement in standard care treatments such as psychiatric medication management, and evidence-based psychotherapy targeting mTBI or PTSD symptoms.
* Prior U.S military service (any duration and any branch) is required for eligibility.

Exclusion criteria:

* Age over 55 to reduce confounding effects of age-related neurodegeneration and cognitive decline.
* Diagnosis of severe psychiatric disorders (e.g., schizophrenia, bipolar disorder).
* Active substance abuse.
* Presence of unrelated neurological conditions such as epilepsy, stroke, seizure disorders, or neurodegenerative diseases (e.g., Alzheimer's, Parkinson's).
* Significant cognitive impairment, assessed by standardized cognitive screening, which would interfere with the ability to participate fully in VR and therapy sessions.
* Physical impairments that would prevent safe engagement in VR and therapy.

Where it's running

• Johns Hopkins Bayview Medical Center - Pyschiatry
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Durga Roy, MD — Johns Hopkins University
• Study coordinator: Saumik Das
• Email: sdas41@jh.edu
• Phone: 703-554-0332

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.