Condition

Brain Injury clinical trials and research

• 14Clinical trials
• 436NIH research projects
• 2New in 30 days
• 6Countries

Newest Brain Injury clinical trials

All recruiting trials (14)

• Exploration of whole-brain radiotherapy with PD-1 inhibitors for brain injury in SCLC

  This study tests whether adding PD-1 inhibitors to chemotherapy and prophylactic brain irradiation helps some small cell lung cancer patients protect the brain.

  Recruiting Guizhou Medical University · Guiyang, Guizhou · NCT07905937

• Informational Needs of Caregivers of Patients in Neuro Rehab: Validating the QBI-R/V

  This study tests a caregiver questionnaire (QBI-R and QBI-V) to see how well it measures caregivers’ informational needs during neuromotor rehabilitation.

  Recruiting at 13 sites Istituti Clinici Scientifici Maugeri SpA · Sciacca, Agrigento and 12 other locations · NCT07903298

• Can a bedside brain scan (fNIRS) detect activity in healthy people and in people with disorders of consciousness

  This observational study tests whether functional near-infrared spectroscopy (fNIRS) can measure brain activity at the bedside in healthy adults and in patients with disorders of consciousness in the Neuro-ICU.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT07485361

• The Coma Family Program: a resilience program for caregivers of patients with severe brain injury

  This program tests whether the Coma Family Program can better reduce emotional distress in caregivers of patients with severe acute brain injury compared to a health education control.

  Recruiting at 3 sites Icahn School of Medicine at Mount Sinai · Baltimore, Maryland and 3 other locations · NCT07331324

• Program to restore resilience and reduce PTSD after military sexual trauma or intimate partner violence with brain injury

  This trial tests whether adding a web-based emotion regulation program to exposure therapy helps female Veterans with military sexual trauma or intimate partner violence and a history of brain injury reduce PTSD symptoms.

  Recruiting Icahn School of Medicine at Mount Sinai · Houston, Texas · NCT06988787

• Q Therapeutic System to improve arm and hand function after chronic stroke

  This trial will try the Q Therapeutic (BQ 3.0) electromagnetic stimulation system with guided arm exercises to see if it improves upper limb function in people 6 months to 5 years after a stroke.

  Recruiting Burke Rehabilitation Hospital · White Plains, New York · NCT06979466

• Using Vagus Nerve Stimulation and Robotic Mobilization for Patients with Prolonged Disorders of Consciousness

  This study is testing if combining a special nerve stimulation treatment with robotic help to move can improve the recovery of patients who have been in a prolonged state of unconsciousness.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT06930716

• Evaluating neurometabolic networks for predicting survival in colorectal cancer

  This study is testing a new way to predict survival in colorectal cancer patients by looking at how different networks in the body interact and affect outcomes.

  Recruiting The First Affiliated Hospital of Zhengzhou University · Henan, Henan · NCT06930586

• Group therapy for mental health in people with neurological disorders

  This study is testing if group therapy using Acceptance and Commitment Therapy can help improve mental health for people with neurological disorders, including those recovering from COVID-19.

  Recruiting Bielefeld University · Bielefeld · NCT06897553

• Brain biobank for research on brain diseases

  This study is setting up a brain bank to collect donated brains after death to help researchers find better ways to diagnose and treat brain diseases like Alzheimer's and dementia.

  Recruiting University of Central Florida · Orlando, Florida · NCT06876857

• Comparing IV methadone versus IV remifentanil for pain and recovery after craniotomy

  This trial will test whether a single dose of IV methadone given during surgery provides better pain control and recovery than IV remifentanil for adults having supratentorial craniotomy.

  Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT06810336

• Using breast milk to treat brain injury in newborns

  This study is testing if giving breast milk through the nose can help newborns with brain injuries feel better and develop normally while they are being treated with cooling therapy.

  Recruiting Early Phase 1 Semmelweis University · Budapest · NCT06747260

• Biofeedback training for improving vision in patients with hemianopia

  This study tests if biofeedback training can help people with vision loss from brain injuries learn to see better by improving how they move their eyes and focus on things.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05397873

• Comparing telehealth and in-person training for veterans with brain injuries and PTSD

  This study tests whether veterans with brain injuries and PTSD can benefit just as much from online training as they do from in-person training to improve their attention and problem-solving skills.

  Recruiting VA Office of Research and Development · Gainesville, Florida · NCT05380050

NIH-funded research (newest 40 of 436)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Waixenicin A-based therapy for newborn brain injury

  A new drug-target approach aims to protect babies’ brains after oxygen deprivation at birth.

  NIH research Baylor University · Waco, United States · NIH-11626463

• AI-enhanced virtual reality tool to support remote emergency brain surgery training in Tanzania

  A new AI-powered virtual reality tool helps non-experts in low-resource areas get real-time remote guidance for emergency traumatic brain injury surgery.

  NIH research Duke University · Durham, United States · NIH-11625286

• Modulating a brain lipid to reduce injury after newborn brain injury

  Aims to test a treatment that changes a brain lipid to lessen damage after a baby’s brain has been deprived of oxygen.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11597985

• How head injury affects the heart and blood vessels

  This project aims to find out whether traumatic brain injuries make people more likely to develop hardened arteries and heart problems, especially among veterans.

  NIH research Veterans Health Administration · Ann Arbor, United States · NIH-11520843

• Brain injury risk in preterm babies with heart disease and how surgery choices affect their brains

  This project follows newborns with congenital heart disease born early to understand how their brains are affected and how different surgical approaches might influence outcomes.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11520488

• Neural targets for improving function in Veterans with alcohol use disorder and mild brain injury

  This project tests a targeted brain-stimulation approach to help Veterans who have both alcohol use problems and mild traumatic brain injury improve daily functioning.

  NIH research Edward Hines Jr VA Hospital · Hines, United States · NIH-11518051

• How head injuries affect the heart and blood vessels

  This project is looking at whether past traumatic brain injuries cause changes in blood vessels and raise the risk of heart disease for people who have had head injuries.

  NIH research Veterans Health Administration · Ann Arbor, United States · NIH-11516262

• Newborn brain injury risk during birth transition in babies with congenital heart defects

  This project will look at how circulation changes around birth affect newborn brain health in babies with transposition of the great arteries.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11474556

• Keeping oxygen in the injured brain after severe head trauma

  This project uses a small brain oxygen monitor to guide ICU care for people with severe traumatic brain injury in hopes of improving recovery.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11474479

• Brain small-vessel injury and its link to Alzheimer's disease

  This project will look for connections between small blood-vessel damage in the brain and later memory decline in older adults without dementia, including Black and Hispanic participants.

  NIH research University of California-Irvine · Irvine, United States · NIH-11472083

• How head injuries affect Parkinson's over time

  Researchers will follow people with Parkinson's disease to learn how past mild-to-moderate head injuries relate to thinking, mood, movement, brain changes, and quality of life.

  NIH research Veterans Health Administration · Gainesville, United States · NIH-11471961

• Brain oxygen monitoring to help recovery after severe head injury

  This project uses a brain oxygen sensor to guide ICU care for people with severe traumatic brain injury.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11471593

• Keeping the brain better oxygenated after severe head injury

  This trial compares using a small brain oxygen sensor plus targeted treatments to standard ICU care for people with severe traumatic brain injury to reduce low brain oxygen and help recovery.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11471592

• Brain oxygen monitoring to improve recovery after severe head injury

  This project compares standard intracranial pressure care with added brain-tissue oxygen monitoring to help people with severe traumatic brain injury avoid low brain oxygen and improve recovery.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11471591

• Using realistic brain-injury models to improve recovery after TBI

  This project builds a realistic large-animal model of traumatic brain injury to find rehabilitation approaches that help people recover thinking, sleep, and daily function after TBI.

  NIH research Philadelphia VA Medical Center · Philadelphia, United States · NIH-11465348

• Chronic Traumatic Brain Injury and Epilepsy: Finding New Ways to Stop Seizures

  This grant explores how repetitive and complex brain injuries lead to epilepsy and cognitive problems, with a focus on Veterans suffering from traumatic brain injury.

  NIH research Philadelphia VA Medical Center · Philadelphia, United States · NIH-11461090

• Viral Factors in the Prenatal Brain: How HEXB and Lysosomes Shape Baby Brain Health

  This grant explores how a mother’s viral infection during pregnancy can affect a baby’s brain, focusing on a specific enzyme (HEXB) and lysosome function to understand and prevent brain injuries.

  NIH research Children's Research Institute · Washington, United States · NIH-11460958

• Sleep patterns predicting recovery after acute brain injury

  Researchers will look at brain sleep signals to see if certain sleep patterns can forecast when patients who are unconscious after a brain injury may start to wake up and recover.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11458485

• Optimizing brain chemical signaling to help people after traumatic brain injury

  A small study will test whether a drug called modafinil can improve thinking, attention, and emotional regulation in adults who have had a traumatic brain injury.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11454996

• Glycan signals in neutrophils and pneumonia risk after brain injury

  This grant explores how immune Cells in people with brain injury may become more prone to pneumonia due to changes in sugars on their cells, with the goal of preventing infections.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11451948

• Biological mechanisms behind worsening brain decline after older adults’ mild brain injury

  This research looks at why some older adults experience dementia-like decline after a mild traumatic brain injury and how it links to Alzheimer’s disease.

  NIH research Lovelace Biomedical Research Institute · Albuquerque, United States · NIH-11450413

• Mild Traumatic Brain Injury: A High-Tech Look Inside the Brain with Diffusion MRI

  Researchers are using advanced brain imaging to find biological clues in people who have mild traumatic brain injuries.

  NIH research New York University School of Medicine · New York, United States · NIH-11450398

• Traumatic Brain Injury Across Life: How TBI Relates to Later Dementia Risk

  This study looks at how head injuries over a person’s life affect their chances of developing Alzheimer's disease or related dementias later on.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11449670

• New noninvasive brain-monitoring tech to help kids after traumatic brain injury

  A new noninvasive optical device is being developed to detect brain problems early in children who have suffered a traumatic brain injury.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11449404

• Microglia-derived vesicles and brain-artery inflammation after brain injury

  This NIH grant explores how tiny brain cell packages from microglia after a brain injury may drive inflammation and accelerate artery disease, potentially helping people who’ve had a traumatic brain injury.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11448649

• Community-based aerobic exercise for adults with moderate to severe traumatic brain injury

  A year-long aerobic exercise program is being tested to see if it can improve thinking, mood, and quality of life for adults aged 45–80 who have had moderate to severe traumatic brain injury.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11448198

• Aldo-keto reductase (AKR) helps brain BH4 levels after injury

  This grant tests whether brain AKR enzymes can boost BH4 levels and support better brain function after hypoxia-ischemia-related injury.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11447154

• How neuromodulation may help headaches after a mild brain injury

  A small study tests whether stimulating the brain with a noninvasive technique can lessen persistent headaches in people who recently had a concussion.

  NIH research Upstate Medical University · Syracuse, United States · NIH-11441465

• Kuishi-TBI App: Mobile care tool for traumatic brain injury in Tanzania

  A mobile health app to help triage, guide treatment, and educate TBI patients in Tanzania and similar settings.

  NIH research Kilimanjaro Christian Medical Centre · Moshi, TANZANIA U REP · NIH-11440852

• Smoking and blood vessel health linked to brain aging in adults

  This project looks at how smoking and quitting affect tiny and large blood vessels in the brain and body, and how these changes relate to brain aging and dementia risk.

  NIH research Vassar College · Poughkeepsie, United States · NIH-11440357

• Caregiver Wellness support for adults after moderate-to-severe traumatic brain injury

  A caregiver-focused program delivered by web and phone helps family members of adults with moderate-to-severe TBI feel better and support the person they care for.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11433071

• The role of Slc25a1 in brain immune cell activation after traumatic brain injury

  This project looks at how a specific cell “gatekeeper” protein (Slc25a1) affects inflammatory brain cells after a traumatic brain injury, with the aim of finding ways to reduce long-term damage.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11426288

• NOX2 and microglia in brain injury: a potential path to better recovery

  After a traumatic brain injury, harmful brain inflammation driven by microglia may lead to ongoing damage; this grant tests a targeted approach to calm microglia by focusing on NOX2 to protect brain function.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11419561

• New ways to treat chronic pain after mild brain injuries

  A research team is studying why some people develop long-lasting pain after a mild head injury and how brain inflammation contributes to it.

  NIH research Rlr VA Medical Center · Indianapolis, United States · NIH-11418233

• Targeting new molecular pathways to improve brain health after chronic reduced blood flow

  A lab-led project tests new molecular targets to protect brain blood vessels and improve thinking skills in people affected by vascular brain injury due to long-term low blood flow.

  NIH research Veterans Health Administration · Pittsburgh, United States · NIH-11412233

• Retraining brain pathways to boost thinking after a mild head injury

  A clinical trial tests a brain-training program to improve thinking and memory in people who have had a mild traumatic brain injury (mTBI).

  NIH research Perception Dynamics Institute · Encinitas, UNITED STATES · NIH-11406497

• Oxidized brain fats after head injuries in children

  Researchers are looking at how specific damaged brain fats after serious head injuries in children may cause brain cell loss and point to better treatments.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11401227

• Optimizing caffeine therapy to protect kidneys and brain in preterm babies

  A randomized study tests whether giving caffeine to very premature babies with kidney and brain hypoxia can reduce kidney injury and improve early brain and kidney outcomes.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11400275

• Two treatment approaches for severe head injuries in children in Latin America

  It compares care guided by pressure monitors inside the skull to care guided by scans and exams for children and teens with severe head injuries.

  NIH research University of Washington · Seattle, United States · NIH-11399631

• Careful comparison of inpatient rehab methods after traumatic brain injury

  A large study will follow people with moderate to severe brain injury to see which inpatient rehab practices help them recover best.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11399079

Related topics

Quick answers

How many Brain Injury clinical trials are recruiting right now?

14, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (8 trials), China (2 trials), Germany (1 trial), Hungary (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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