Evaluating the effects of beta blockers on outcomes in traumatic brain injury patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of adjuvant beta blockers, specifically propranolol and carvedilol, on clinical outcomes in patients suffering from moderate to severe traumatic brain injury (TBI). The study aims to understand how the different receptor blockade profiles of these medications may influence secondary brain injury processes and overall patient recovery. Patients will be monitored for their responses to the treatments compared to a control group, with a focus on improving outcomes for those with TBI. The trial is designed to gather data that could lead to better therapeutic strategies for managing TBI.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1\. Patients with moderate \& severe TBI detected on admission by CT scan and GCS score of ≤ 13 who either do not have any other injuries or only have associated minor injuries.

Minor injuries are defined as presence of any of the following:

1. Mild intraperitoneal free fluid (IPFF) observed through abdominal ultrasound.
2. mild lung contusion detected in the chest CT scan.
3. hemothorax or pneumothorax present without accompanying symptoms of hypoxia, tachypnea, or respiratory distress.
4. simple limb fractures.

Exclusion Criteria:

1. Patients on pre-injury beta-blocker therapy.
2. Patients with any bronchospastic conditions.
3. Patients with active acute coronary syndrome.
4. TBI with GCS ≤ 13 with associated major injuries defined as the presence of any of the following:

   1. Moderate \& marked IPFF requiring surgical intervention ( laparotomy ).
   2. moderate \& marked lung contusion, pneumothorax \& hemothorax with accompanying symptoms of hypoxia, tachypnea, lower limbs, or limb amputation.
   3. Compound fracture in the upper or lower limb.
   4. Open Faciomaxillary trauma.
5. Patients with persistent shock (systemic blood pressure \<100 mmHg, base deficit \> 4, or oliguria , HR \< 60 b/min ) after \> one week of admission.

Where it's running

• Zagazig University Hospitals, Zagazig,
  Zagazig, Egypt Recruiting
• Zagazig University Hospitals
  Zagazig, Egypt Not yet recruiting

Study contacts

• Study coordinator: Aya Osama Nagaty
• Email: doctoraya_15@yahoo.com
• Phone: 00201097721011

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Long-lasting effects of hyperbaric oxygen therapy on thinking after traumatic brain injury

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.