Investigating how HIV and opioids affect stroke risk and recovery
Official title: Targeting Inflammasomes in Substance Abuse and HIV
Funded at University of Miami School of Medicine · NIH-10860986 · Data updated 2026-11-12
This study is looking at how HIV brain infection and using prescription opioids might increase the risk of strokes in people living with HIV, and it aims to find ways to protect the brain and improve recovery for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | July 15, 2020 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $424,010 |
| NIH project number | 5R01DA050528-05 |
| Project ID | NIH-10860986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV who also have a history of opioid use or abuse.
✕Less likely to help
Patients who do not have HIV or a history of opioid use may not benefit from this research.
What this research studies
This research explores the relationship between HIV brain infection, prescription opioid use, and the risk of ischemic stroke, which is a significant health issue for individuals living with HIV and those who abuse opioids. The study aims to understand how these factors activate inflammasomes in the central nervous system, potentially worsening stroke outcomes and leading to HIV reactivation. The researchers will evaluate the mechanisms behind this activation and seek to develop therapeutic strategies targeting mitochondria to protect against these effects. By addressing these critical interactions, the research aims to improve recovery outcomes for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with HIV and opioid use disorder, reducing the risk of stroke and enhancing recovery.
How similar studies have gone: While the specific combination of HIV, opioids, and stroke has not been extensively studied, related research on inflammasome activation and its effects on various conditions has shown promising results.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Toborek, Michal — University of Miami School of Medicine
- Study coordinator: Toborek, Michal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.