Investigating how HIV and opioids affect stroke risk and recovery
Targeting Inflammasomes in Substance Abuse and HIV
['FUNDING_R01'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-10860986
This study is looking at how HIV brain infection and using prescription opioids might increase the risk of strokes in people living with HIV, and it aims to find ways to protect the brain and improve recovery for those affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-10860986 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between HIV brain infection, prescription opioid use, and the risk of ischemic stroke, which is a significant health issue for individuals living with HIV and those who abuse opioids. The study aims to understand how these factors activate inflammasomes in the central nervous system, potentially worsening stroke outcomes and leading to HIV reactivation. The researchers will evaluate the mechanisms behind this activation and seek to develop therapeutic strategies targeting mitochondria to protect against these effects. By addressing these critical interactions, the research aims to improve recovery outcomes for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV who also have a history of opioid use or abuse.
Not a fit: Patients who do not have HIV or a history of opioid use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with HIV and opioid use disorder, reducing the risk of stroke and enhancing recovery.
How similar studies have performed: While the specific combination of HIV, opioids, and stroke has not been extensively studied, related research on inflammasome activation and its effects on various conditions has shown promising results.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TOBOREK, MICHAL — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: TOBOREK, MICHAL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.