Virtual reality-based cognitive and physical rehab for people with mild cognitive impairment or subjective cognitive decline
Official title: Feasibility, Usability, and Acceptability of Virtual Reality-Based Cognitive and Physical Rehabilitation in Individuals With Mild Cognitive Impairment (VR-MCI)
Run by The University of Texas Health Science Center, Houston · NCT07638748 · Data updated 2026-11-12
This study tests whether VR-based cognitive and physical rehabilitation is feasible, usable, and acceptable for people with mild cognitive impairment or subjective cognitive decline.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 55 Years to 90 Years |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | The University of Texas Health Science Center, Houston Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | June 18, 2026 |
| Main results expected | November 13, 2026 |
| Study ends | November 13, 2026 |
| Registry record updated | September 2, 2026 |
| Trial ID | NCT07638748 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with a clinical diagnosis of MCI (MoCA 18–26) or those with self-reported subjective cognitive decline who can provide informed consent, speak English, and attend sessions.
✕Probably not a fit
Individuals who experience significant contraindications to VR, cannot tolerate VR, or have conditions that interfere with participation may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project is a feasibility study to see if virtual reality–driven cognitive and physical rehabilitation can be implemented in this population. It will measure how well participants can use the VR sessions, how often they adhere to the program, and how tolerable the experience is. The study will also explore preliminary effects on cognitive, physical, and daily functional outcomes. No efficacy claims are made until data support is gathered.
Why it matters
Potential benefit: If successful, VR rehabilitation could become a convenient option to help maintain or improve cognitive and physical function in this group.
How similar studies have gone: Previous approaches using VR for cognitive and/or physical rehab have shown feasibility in related populations, but this specific combination in MCI/SCD is still being explored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of MCI (MoCA 18-26) or self-reported subjective cognitive decline (SCD) * Capacity to provide informed consent * Able to provide own transportation to sessions * Speaks and understands English * Ambulatory Exclusion Criteria: * Uncontrolled seizures or epilepsy * Severe psychiatric illness or active suicidality * Inability to follow instructions or tolerate VR (severe motion sickness) * Cognitive impairment as a result of a known cause (e.g., dementia, stroke, Traumatic Brain Injury (TBI), medications, etc.) * Any condition that the research team determines would interfere with safe participation
Where it's running
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The University of Texas Health Science Center at Houston
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Seema Aggarwal, PhD, APRN, AGNP-C — The University of Texas Health Science Center, Houston
- Study coordinator: Seema S Aggarwal, PhD, APRN, AGNP-C
- Email: Seema.S.Aggarwal@uth.tmc.edu
- Phone: (713) 500-9946
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.