Daily-life Virtual Reality Training to Support Thinking and Daily Tasks in adults 50 and older
Official title: The Efficacy of an IADL-based Non-immersive Virtual Reality Training Program to Enhance ADL Performance and Cognitive Function for Persons at Risk of Dementia
Run by National Taiwan University Hospital · NCT07895979 · Data updated 2026-11-12
A touchscreen-based daily-life VR program is being tested to see if it helps people 50+ improve daily activities and thinking skills, especially for those at risk of dementia.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years and up |
| Sex | All |
| Enrollment | 216 (estimated) |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 1 site (Taipei) |
| Status | Recruiting |
| Started | February 6, 2026 |
| Main results expected | July 31, 2027 |
| Study ends | July 31, 2027 |
| Registry record updated | November 9, 2026 |
| Trial ID | NCT07895979 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 50+ with Chinese literacy and basic education, including those with Subjective Cognitive Decline or Mild Cognitive Impairment, who meet MoCA and SCD-Q criteria.
✕Probably not a fit
Participants who do not show improvements in daily activities or cognitive tasks, or who do not fit the MoCA/SCD-Q criteria, may not experience benefit from this program.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial compares a daily-life immersive VR training against a non-situational VR game and a traditional tabletop cognitive program to see which best improves instrumental activities of daily living and cognitive functions. It includes adults aged 50 and above who can read and write Chinese and have basic education. Outcomes include changes in complex daily activities, memory, attention, problem solving, mood, and brain activity. The study also examines personal factors that influence training results. It is sponsored by National Taiwan University Hospital and conducted at National Taiwan University.
Why it matters
Potential benefit: If successful, participants may experience better daily functioning and sharper thinking, potentially slowing progression of cognitive difficulties.
How similar studies have gone: Prior studies using VR for cognitive training have shown mixed results, with some demonstrating improvements in targeted tasks and daily functioning.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: General Inclusion Criteria (Applicable to All Participants): * Aged 50 years or older. * Completed at least elementary school education (6 or more years of formal education) and able to read and write in Chinese. Group-Specific Inclusion Criteria: 1. Cognitively Healthy Middle-Aged and Older Adults Group: * Taiwanese version of the Montreal Cognitive Assessment (MoCA) score \> 26. * Does not meet the diagnostic criteria for Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), or dementia. 2. Subjective Cognitive Decline (SCD) Group: * Taiwanese version of the Montreal Cognitive Assessment (MoCA) score \> 23. * Subjective Cognitive Decline Questionnaire (SCD-Q) score \> 7 (out of a total score of 24). * Answers "Yes" to both of the following questions: "Do you feel that you have memory problems compared to your previous normal state?" and "Have your family members or close friends noticed that you have memory problems compared to your previous state?" * Normal performance on standardized neuropsychological tests (Color Trails Test and memory-related tests), defined as scoring higher than 1.5 standard deviations below the age- and education-adjusted normative mean. * Does not meet the diagnostic criteria for Mild Cognitive Impairment (MCI) or dementia. 3. Mild Cognitive Impairment (MCI) Group: * Taiwanese version of the Montreal Cognitive Assessment (MoCA) score \> 21. * Diagnosed with Mild Cognitive Impairment (MCI) by a neurologist or psychiatrist. * Does not meet the diagnostic criteria for dementia. Exclusion Criteria (Applicable to All Participants): * Meets the clinical diagnostic criteria for dementia. * Geriatric Depression Scale Short-Form (GDS-S) score \>= 8, or cognitive changes caused by other psychiatric disorders, neurological diseases, or substance abuse with unstable medical conditions and interfering symptoms. * Severe visual or hearing impairments that prevent the completion of cognitive function assessments. * Physical illnesses or conditions that prevent participation in the cognitive and physical training interventions.
Where it's running
-
School of Occupational Therapy, College of Medicine, National Taiwan University
Taipei, Taiwan Recruiting
Study contacts
- Study coordinator: Hui-Fen Mao
- Email: huifen02@gmail.com
- Phone: 886-3366-8178
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.