Personalized Brain Health Service for Dementia Prevention in People with Subjective Cognitive Decline
Official title: Implementation of a Brain Health Service for Personalized Stratification and Prevention of Dementia Risk: The B-HEALTH Project
Run by Barcelonabeta Brain Research Center, Pasqual Maragall Foundation · NCT07698431 · Data updated 2026-11-12
This study tests a personalized Brain Health Service to see if tailored risk assessment and a 6‑month lifestyle program can lower dementia risk for people aged 55–85 who have subjective cognitive concerns.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 55 Years to 85 Years |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Barcelonabeta Brain Research Center, Pasqual Maragall Foundation Academic / other |
| Locations | 1 site (Barcelona, Catalonia) |
| Status | Recruiting |
| Started | September 15, 2026 |
| Main results expected | December 31, 2027 |
| Study ends | August 1, 2028 |
| Registry record updated | September 16, 2026 |
| Trial ID | NCT07698431 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are 55–85 years old with subjective cognitive complaints, normal cognitive screening, and sufficient digital literacy to use digital tools.
✕Probably not a fit
Individuals with objective cognitive impairment or major neurological or psychiatric conditions may not benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial will recruit 120 adults with subjective cognitive decline and normal cognitive testing from Barcelona’s cognitive disorders units. Participants are randomly assigned to receive either a personalized intervention or general prevention advice. The intervention combines digital and in-person strategies to address modifiable risk factors and provides structured, optional risk communication and counseling based on individual risk profiles. Outcomes will focus on feasibility of implementing the Brain Health Service and potential changes in risk factors over six months. Background evidence suggests multimodal lifestyle approaches may reduce dementia risk, but clinical validation in routine care settings is needed.
Why it matters
Potential benefit: If successful, participants could gain access to personalized risk insight and targeted lifestyle guidance that may reduce their risk of progressing to dementia.
How similar studies have gone: Previous studies indicate that multimodal lifestyle interventions can reduce dementia risk factors, supporting the rationale for this approach, though translational validation is ongoing.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants aged 55 to 85 with subjective cognitive complaints and normal screening test performance at the hospital. * Participants must have a minimal educational level for a neuropsychological assessment and a minimal digital literacy for the usage of smartphones, computers and Internet. Exclusion Criteria: * Objective cognitive impairment. * Clinically relevant neurological disorders. * Major psychiatric disorders. * History of drug/alcohol abuse. * Unstable medical conditions that could fully explain cognitive complaints, as determined by the investigator.
Where it's running
-
Fundació Pasqual Maragall
Barcelona, Catalonia, Spain Recruiting
Study contacts
- Study coordinator: Oriol Grau Rivera
- Email: ograu@barcelonabeta.org
- Phone: +34 933 26 31 90
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.