Short-term supraspinatus tendon changes after two shoulder exercise sessions.
Official title: Supraspinatus Tendon Acute Effects After Two Exercise Exposures: a Crossover Randomized Trial.
Run by University of Florida · NCT07489937 · Data updated 2026-11-12
This study will test whether two different 15-minute shoulder exercise programs cause short-term tendon changes in adults with and without shoulder pain.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | University of Florida Academic / other |
| Locations | 1 site (Gainesville, Florida) |
| Status | Recruiting |
| Started | April 20, 2026 |
| Main results expected | April 1, 2027 |
| Study ends | April 1, 2027 |
| Registry record updated | April 22, 2026 |
| Trial ID | NCT07489937 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–45 who can perform moderate shoulder activity, either with unilateral shoulder pain averaging ≥3/10 in the past week or pain-free controls with no shoulder pain in the last six months, are ideal candidates.
✕Probably not a fit
People with full rotator cuff tears, prior shoulder surgery, frozen shoulder, bilateral shoulder pain, shoulder instability, recent corticosteroid injection, uncontrolled diabetes, significant cardiac/neurological/systemic disease, pregnancy, or inability to perform moderate shoulder activity are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with and without unilateral shoulder pain will each complete two different supervised shoulder exercise sessions (isotonic and plyometric) in a randomized crossover order separated by up to 15 days. Researchers will use ultrasound to measure supraspinatus tendon appearance before exercise and at 1 hour, 6 hours, and 24 hours after each session. Participants will also report pain levels, complete pain-sensitivity testing, and fill out questionnaires about symptoms and function. Tendon responses after each exercise type will be compared within individuals and between the pain and control groups.
Why it matters
Potential benefit: If successful, results could help clinicians choose shoulder exercises that produce less harmful short-term tendon changes and better guide rehabilitation strategies.
How similar studies have gone: Prior small studies have reported short-term changes in tendon thickness and mechanical properties after loading, but results are mixed and direct comparisons between isotonic and plyometric loading are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
General inclusion criteria 1. Between 18 and 45 years of age 2. Able to perform physical activity with their shoulder (moderate arm exercise for 15 min, such as tennis or housework) General exclusion criteria 1. Shoulder fracture 2. Frozen shoulder (\>50% restriction in shoulder range of motion) 3. Shoulder surgery 4. Full rotator-cuff tears 5. Bilateral shoulder pain 6. Shoulder instability (history or positive apprehension test) 7. Corticosteroid injection in the last 6 weeks 8. Neurological diseases 9. Cardiological diseases 10. Systemic diseases (rheumatic diseases, autoimmune diseases) 11. Uncontrolled diabetes 12. Pregnancy Group-specific inclusion criteria 1. Shoulder pain group: report unilateral shoulder pain with an average shoulder pain score of≥ 3 in the last week. 2. Control group: report no shoulder pain within 6 months.
Where it's running
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University of Florida
Gainesville, Florida, United States Recruiting
Study contacts
- Study coordinator: Ignacio A Raguzzi, PT
- Email: iraguzzi@ufl.edu
- Phone: 352-665-4947
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.