Noninvasive treatment for shoulder pain linked to liver issues
Official title: Effectiveness of Noninvasive Phrenic Nerve Neuromodulation in Subjects With Right Shoulder Pain and Hepatobiliary Visceral Comorbidity.
Run by University of Seville · NCT06296979 · Data updated 2026-11-12
This study is testing a new noninvasive treatment for shoulder pain that might be linked to liver problems to see if it can help relieve the pain.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 34 (estimated) |
| Sponsor | University of Seville Academic / other |
| Locations | 4 sites (Seville, Sevilla and 3 other locations) |
| Status | Recruiting |
| Started | March 20, 2024 |
| Main results expected | December 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | April 2, 2025 |
| Trial ID | NCT06296979 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 with right shoulder pain and a diagnosed hepatobiliary disorder.
✕Probably not a fit
Patients with chronic pain from other diseases, such as malignancies or rheumatic diseases, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of noninvasive phrenic nerve neuromodulation in treating shoulder pain that may be related to hepatobiliary visceral disorders. It aims to understand how visceral conditions can cause referred pain in the shoulder area and whether neuromodulation can alleviate this pain. The approach involves assessing patients with right shoulder pain and associated liver conditions, utilizing both neuromodulation techniques and physical therapy as interventions.
Why it matters
Potential benefit: If successful, this treatment could provide significant relief for patients suffering from shoulder pain linked to liver conditions.
How similar studies have gone: While the concept of visceral referred pain is established, this specific approach to phrenic nerve neuromodulation is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Over 18 years of age. * Subjects presenting right shoulder pain at the time of enrollment in the study. * Presentation of a hepatobiliary visceral disorder that may justify the visceral etiology of the pain. * That they agree to participate in the project by signing the informed consent form. Exclusion Criteria: * Patients with chronic pain due to other diseases such as malignant disease. * Patients with rheumatic diseases. * Cutaneous infection in the area of pain. * Disease of neurological, traumatic, oncologic, or infectious origin that rules out the visceral origin of the pain. * Uncooperative subject. * Severe psychiatric disease. * Loss of cognitive capacity. * Contraindication to electrotherapy.
Where it's running
-
Centro de Salud Ronda Histórica
Seville, Sevilla, Spain Recruiting -
Centro de Salud las Letanías
Seville, Sevilla, Spain Recruiting -
Centro de Salud Bellavista
Seville, sevilla, Spain Recruiting -
Centro de especialidades Morón de la Frontera
Morón de la Frontera, Seville, Spain Recruiting
Study contacts
- Principal investigator: Ángel Oliva Pascual-Vaca, Dr — University of Seville
- Study coordinator: Adolfo Rosado Portillo
- Email: adolforosadoportillo@gmail.com
- Phone: 605663879
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Functional electrical stimulation plus shoulder exercises for older adults with rotator cuff pain
In older adults with rotator cuff–related shoulder pain, this study tests whether adding functional electrical stimulation to a shoulder exercise program improves muscle coordination and reduces impingement compared with exercises alone.
-
Shoulder pain patients: see if breathing and chest exercises help pain and sleep
This study tests whether adding respiratory muscle strengthening and diaphragmatic breathing to shoulder rehab can reduce pain and improve sleep in adults with chronic shoulder pain.
-
Night Pain Module for Rotator Cuff-Related Shoulder Pain
Researchers are testing a short set of questions to measure night pain in people with rotator cuff–related shoulder pain to see if it reliably describes how sleep is affected.
-
Nociplastic Pain in SAPS: A Look at Pain Types in Shoulder Pain
This study tests how common nociplastic pain is among people with subacromial pain syndrome who have shoulder pain for at least 3 months.
-
Pain phenotype and response to corticosteroid injection in SAPS
This study tests whether people with subacromial pain syndrome who have a nociplastic pain pattern respond differently to a corticosteroid injection than those without that pattern.
-
Spinal and Kaltenborn mobilization for a stiff shoulder (frozen shoulder)
A randomized trial tests spinal mobilization with arm movement and Kaltenborn mobilization to see if they reduce pain and improve motion and function in people with adhesive capsulitis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.