Clinical trial Recruiting at 4 sites Interventional Ages 18 and up

Noninvasive treatment for shoulder pain linked to liver issues

Official title: Effectiveness of Noninvasive Phrenic Nerve Neuromodulation in Subjects With Right Shoulder Pain and Hepatobiliary Visceral Comorbidity.

Run by University of Seville · NCT06296979 · Data updated 2026-11-12

This study is testing a new noninvasive treatment for shoulder pain that might be linked to liver problems to see if it can help relieve the pain.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment34 (estimated)
SponsorUniversity of Seville
Academic / other
Locations4 sites (Seville, Sevilla and 3 other locations)
StatusRecruiting
StartedMarch 20, 2024
Main results expectedDecember 1, 2026
Study endsDecember 1, 2026
Registry record updatedApril 2, 2025
Trial IDNCT06296979 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults over 18 with right shoulder pain and a diagnosed hepatobiliary disorder.

Probably not a fit

Patients with chronic pain from other diseases, such as malignancies or rheumatic diseases, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of noninvasive phrenic nerve neuromodulation in treating shoulder pain that may be related to hepatobiliary visceral disorders. It aims to understand how visceral conditions can cause referred pain in the shoulder area and whether neuromodulation can alleviate this pain. The approach involves assessing patients with right shoulder pain and associated liver conditions, utilizing both neuromodulation techniques and physical therapy as interventions.

Why it matters

Potential benefit: If successful, this treatment could provide significant relief for patients suffering from shoulder pain linked to liver conditions.

How similar studies have gone: While the concept of visceral referred pain is established, this specific approach to phrenic nerve neuromodulation is relatively novel and has not been extensively tested in prior studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Over 18 years of age.
* Subjects presenting right shoulder pain at the time of enrollment in the study.
* Presentation of a hepatobiliary visceral disorder that may justify the visceral etiology of the pain.
* That they agree to participate in the project by signing the informed consent form.

Exclusion Criteria:

* Patients with chronic pain due to other diseases such as malignant disease.
* Patients with rheumatic diseases.
* Cutaneous infection in the area of pain.
* Disease of neurological, traumatic, oncologic, or infectious origin that rules out the visceral origin of the pain.
* Uncooperative subject.
* Severe psychiatric disease.
* Loss of cognitive capacity.
* Contraindication to electrotherapy.

Where it's running

  • Centro de Salud Ronda Histórica
    Seville, Sevilla, Spain
    Recruiting
  • Centro de Salud las Letanías
    Seville, Sevilla, Spain
    Recruiting
  • Centro de Salud Bellavista
    Seville, sevilla, Spain
    Recruiting
  • Centro de especialidades Morón de la Frontera
    Morón de la Frontera, Seville, Spain
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.