Noninvasive treatment for shoulder pain linked to liver issues

Effectiveness of Noninvasive Phrenic Nerve Neuromodulation in Subjects With Right Shoulder Pain and Hepatobiliary Visceral Comorbidity.

Not applicable Interventional University of Seville · NCT06296979

This study is testing a new noninvasive treatment for shoulder pain that might be linked to liver problems to see if it can help relieve the pain.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment34 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Seville Academic / other
Locations4 sites (Seville, Sevilla and 3 other locations)
Trial IDNCT06296979 on ClinicalTrials.gov

What this trial studies

This study investigates the effectiveness of noninvasive phrenic nerve neuromodulation in treating shoulder pain that may be related to hepatobiliary visceral disorders. It aims to understand how visceral conditions can cause referred pain in the shoulder area and whether neuromodulation can alleviate this pain. The approach involves assessing patients with right shoulder pain and associated liver conditions, utilizing both neuromodulation techniques and physical therapy as interventions.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 with right shoulder pain and a diagnosed hepatobiliary disorder.

Not a fit: Patients with chronic pain from other diseases, such as malignancies or rheumatic diseases, may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide significant relief for patients suffering from shoulder pain linked to liver conditions.

How similar studies have performed: While the concept of visceral referred pain is established, this specific approach to phrenic nerve neuromodulation is relatively novel and has not been extensively tested in prior studies.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Over 18 years of age.
* Subjects presenting right shoulder pain at the time of enrollment in the study.
* Presentation of a hepatobiliary visceral disorder that may justify the visceral etiology of the pain.
* That they agree to participate in the project by signing the informed consent form.

Exclusion Criteria:

* Patients with chronic pain due to other diseases such as malignant disease.
* Patients with rheumatic diseases.
* Cutaneous infection in the area of pain.
* Disease of neurological, traumatic, oncologic, or infectious origin that rules out the visceral origin of the pain.
* Uncooperative subject.
* Severe psychiatric disease.
* Loss of cognitive capacity.
* Contraindication to electrotherapy.

Where this trial is running

Seville, Sevilla and 3 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Shoulder Painphrenic nerveNuromodulation
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.