Condition

Postoperative Cognitive Dysfunction clinical trials and research

• 17Clinical trials
• 4NIH research projects
• 1New in 30 days
• 11Countries

Newest Postoperative Cognitive Dysfunction clinical trials

All recruiting trials (17)

• Tau changes after hip or knee replacement surgery

  Researchers will see if brain tau changes after hip or knee surgery and whether these changes relate to inflammation and thinking abilities.

  Recruiting Uppsala University Hospital · Uppsala · NCT07871487

• Risk of delirium and cognitive problems after TUR-P in older adults

  This study tests whether certain perioperative factors can predict delirium and postoperative cognitive dysfunction in people aged 65 and older undergoing transurethral resection.

  Recruiting Muğla Sıtkı Koçman University · Muğla · NCT07719712

• POCD after major gynecologic surgery in adults

  This study tests how often early postoperative cognitive dysfunction occurs after major gynecologic surgery and what perioperative factors are linked to it.

  Recruiting Kocaeli City Hospital · İzmit, Kocaeli · NCT07589348

• Optic nerve ultrasound to track brain pressure and thinking after Bentall surgery

  This project will test whether bedside ultrasound measurements of the optic nerve sheath before, during, and after elective Bentall surgery can help predict changes in thinking and memory in adult patients.

  Recruiting Bursa Yuksek Ihtisas Training and Research Hospital · Bursa, Yıldırım · NCT07452367

• Remimazolam versus Midazolam for sedation and early thinking recovery in older adults having orthopedic surgery

  This will test whether remimazolam or midazolam gives better sedation and faster early recovery of thinking and memory for people 65 and older undergoing orthopedic surgery with regional anesthesia.

  Recruiting Phase 3 Romanian Society for Enteral and Parenteral Nutrition · Bucharest · NCT07113483

• Assessing brain activity patterns to predict postoperative delirium

  This study is testing if monitoring brain activity during head and neck or plastic surgery can help predict if patients will experience confusion or memory problems afterwards.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06761573

• Using Transcranial Magnetic Stimulation to Prevent Cognitive Issues After Surgery in Older Adults

  This study tests if using Transcranial Magnetic Stimulation can help older adults avoid memory and thinking problems after surgery.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT06658769

• Understanding cognitive recovery in older adults after heart surgery

  This study looks at how heart surgery affects the thinking and memory skills of older adults aged 65 and up, and it also gathers insights from their family members about these changes.

  Recruiting Karolinska Institutet · Gothenburg · NCT06469515

• Monitoring brain health during non-cardiac surgery in older patients

  This study looks at the best blood pressure levels to keep during non-heart surgeries for older patients to help protect their brain health.

  Recruiting Beth Israel Deaconess Medical Center · Boston, Massachusetts · NCT06133842

• Iron supplementation for adolescents with scoliosis

  This study tests if giving iron supplements to teenagers with scoliosis before their surgery can help them recover better and need fewer blood transfusions.

  Recruiting Columbia University · New York, New York · NCT06042699

• Comparing Desflurane, Sevoflurane, and Propofol for Preventing Delirium After Surgery

  This study is testing whether using desflurane instead of sevoflurane or propofol during surgery can help older patients avoid confusion and delirium afterwards.

  Recruiting at 2 sites Phase 4 Medical University of Vienna · Innsbruck and 1 other locations · NCT05990790

• Personalized cardiac anaesthesia and its effects on neurological outcomes in heart surgery patients

  This study is testing if personalized blood pressure management during heart surgery can help prevent neurological problems in patients.

  Recruiting University Hospital, Basel, Switzerland · Basel and 3 other locations · NCT05595954

• Reducing preoperative stress to prevent cognitive issues after heart surgery

  This study is testing if using virtual reality and sound therapy before heart surgery can help reduce stress and prevent memory problems afterward for patients.

  Recruiting Heart and Brain Research Group, Germany · Bad Nauheim, Hesse · NCT05036538

• Analyzing neuroinflammatory markers in cerebrospinal fluid before and after thoracic aortic surgery

  This study is trying to see how levels of certain proteins in the fluid around the brain change before and after thoracic aortic surgery to better understand why some patients experience confusion or memory problems afterward.

  Recruiting Radboud University Medical Center · Nijmegen · NCT04523909

• Cognitive training to prevent cognitive decline after heart surgery

  This study is testing if doing brain exercises before heart surgery can help prevent memory problems and confusion after the surgery for patients undergoing elective cardiac procedures.

  Recruiting Heart and Brain Research Group, Germany · Bad Nauheim · NCT04493996

• Predicting Delirium Risk After Heart Surgery Using a New Cognitive Tool

  This study is testing a new app to see if it can help doctors predict which older patients are at risk of developing confusion after heart surgery.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT03360838

• Evaluation of cognitive dysfunction after surgery

  This study looks at how surgery might affect thinking and memory in patients by comparing their cognitive performance before and after the operation to those who didn't have surgery.

  Recruiting Charite University, Berlin, Germany · Berlin and 1 other locations · NCT02832193

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How anesthesia can affect memory and thinking after surgery

  This research looks at how common anesthetic drugs might lead to memory, attention, or thinking problems after surgery, especially in babies and older adults.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11374157

• Postoperative cognitive function after major cancer surgery in older adults

  A study to understand how brain function changes after major cancer surgery in people 65 and older and what this means for recovery.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11337675

• Postoperative cognitive problems and Alzheimer’s-related dementia: how surgery may affect the aging brain

  Aging patients undergoing surgery may experience brain changes after the operation that could relate to later memory problems and dementia, and this study seeks to understand the biology behind that link.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11307000

• How gut bacteria affect memory problems after surgery

  This study is looking at how the bacteria in your gut might affect memory and thinking skills after surgery, and it aims to find ways to improve gut health to help prevent these issues in patients.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10475064

Related topics

Quick answers

How many Postoperative Cognitive Dysfunction clinical trials are recruiting right now?

17, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in Turkey (Türkiye) (3 trials), Germany (3 trials), Switzerland (2 trials), United States (2 trials), Sweden (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →