POCD after major gynecologic surgery in adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational cohort in adult women undergoing major gynecological surgery under general anesthesia. Cognitive function is measured with the Turkish MoCA before surgery and on postoperative day 3 to identify POCD, defined as either a ≥20% drop from baseline or a ≥2-point decrease. Researchers will collect demographic, frailty, menopausal, inflammatory, and intraoperative data to analyze associations with POCD and to identify high-risk patients. Findings could support personalized perioperative neuroprotective approaches, though causality will not be established in this design.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female patients aged ≥18 years
* Scheduled for elective major gynecological surgery under general anesthesia
* Total abdominal hysterectomy and/or bilateral salpingo-oophorectomy
* Open or laparoscopic surgical approach
* Ability to complete the Turkish version of the Montreal Cognitive Assessment (MoCA)
* Ability to understand and provide written informed consen

Exclusion Criteria:

* Pre-existing dementia or major neurocognitive disorder
* History of cerebrovascular event within the previous 3 months
* Severe visual or hearing impairment preventing cognitive assessment
* Emergency or hemodynamically unstable surgery
* Planned postoperative sedation or mechanical ventilation longer than 72 hours
* Postoperative delirium detected during assessment
* Inability to communicate or cooperate
* Refusal to participate

Where it's running

• University of Health Sciences Kocaeli City Hospital
  İzmit, Kocaeli, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Fatihhan Zeytun, MD
• Email: fatihhanzeytun95@gmail.com
• Phone: 5418405937

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.