Monitoring brain health during non-cardiac surgery in older patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to determine the optimal mean arterial pressure (MAP) to maintain during non-cardiac surgeries for patients aged 60 and above, focusing on brain health. It utilizes non-invasive monitoring techniques, including EEG and cerebral oximetry, to assess brain activity and blood oxygen levels. Participants will complete questionnaires to evaluate their cognitive function before and after surgery, while data will be collected in real-time during the procedure to understand individual variations in optimal blood pressure levels.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 60 years
* Undergoing any non-cardiac surgeries including but not limited to vascular, hepatobiliary, or complex spine surgeries requiring general anesthesia with arterial catheterization for monitoring

Exclusion Criteria:

1. Non-English speaking (Justification: cognitive assessment instruments are not validated in a sufficient range of languages, and the research team lacks polylingual capabilities or the financial resources to hire interpreters for the duration of all proposed assessments.)
2. Cognitive impairment as defined by total MoCA score \< 10 (justification: baseline cognitive dysfunction will confound primary outcome measure)
3. Significant visual impairment (justification: will be difficult for patients to draw individual components in MOCA score)
4. Emergent surgery (justification: insufficient time to initiate intervention)
5. History of stroke within the last 3 months (justification: cognitive dysfunction secondary to stroke can confound outcome measures

Where it's running

• Beth Israel Deaconess Medical Center
  Boston, Massachusetts, United States Recruiting

Study contacts

• Study coordinator: Samir M Kendale, MD
• Email: skendale@bidmc.harvard.edu
• Phone: (617) 975-8500

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.