How gut bacteria affect memory problems after surgery
Gut Microbiota Influences Postoperative Cognitive Dysfunction through Indole-3-Propionic Acid
['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10475064
This study is looking at how the bacteria in your gut might affect memory and thinking skills after surgery, and it aims to find ways to improve gut health to help prevent these issues in patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10475064 on ClinicalTrials.gov |
What this research studies
This research investigates the connection between gut microbiota and postoperative cognitive dysfunction (POCD), which affects a significant number of surgical patients. The study focuses on understanding how changes in gut bacteria may contribute to memory and learning deficits following surgery. By examining the effects of oral antibiotics on gut health and cognitive outcomes in mice, the researchers aim to identify modifiable factors that could help prevent POCD. The ultimate goal is to translate these findings into potential dietary or therapeutic interventions for patients at risk of cognitive decline after surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are surgical patients, particularly older adults, who are at risk for postoperative cognitive dysfunction.
Not a fit: Patients who are not undergoing surgery or those with pre-existing severe cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing memory problems in patients undergoing surgery.
How similar studies have performed: While the role of gut microbiota in various neurological conditions has been explored, this specific investigation into its influence on POCD is relatively novel and untested.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHEN, SHIQIAN — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: SHEN, SHIQIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.