Evaluation of cognitive dysfunction after surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational registry collects data on postoperative cognitive dysfunction (pNCD) from patients undergoing elective surgeries lasting at least 60 minutes. It employs a variety of cognitive tests, both computerized and paper-based, to assess cognitive performance before and after surgery at multiple follow-up points. The study aims to estimate the prevalence and incidence of pNCDs by comparing surgical patients' cognitive outcomes with non-surgical control groups, using established cognitive assessment methodologies.

Why it matters

Who can join: the full rules

Study Group

Inclusion Criteria:

* Age 18 -100 years
* Male or female patients undergoing elective surgery expected to last at least 60 min, screened at the Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Berlin, Germany
* Written informed consent to participate after having been properly instructed

Exclusion Criteria:

* Lacking willingness to take part in the study, or to have relevant study data collected, saved and analyzed for the purpose of the study
* Accommodation in an institution due to an official or judicial order
* Insufficient knowledge of German language
* Members of the hospital staff
* Homelessness or other conditions that disable reachability for postoperative assessment by post or telephone
* Illiteracy
* Patients who had a history of neurologic deficits (e.g. stroke, history of seizures, etc.)
* Hearing impairment that severely affects the neuropsychological testing.
* Visual impairment that severely affects the neuropsychological testing.
* Participation in other prospective clinical interventional trials

Control Group

Inclusion Criteria:

* Age 18 - 100 years
* Male or female patients (ASA Status I, II+III)
* No planned surgery during the next 3 months
* No surgery during the past 6 months before study inclusion
* Written informed consent to participate after having been properly instructed

Exclusion Criteria:

* Insufficient knowledge of German language Lacking willingness to take part in the study, or to have relevant study data collected, saved and analyzed for the purpose of the study
* Neuropsychiatric conditions that severely affect the neuropsychological testing
* Hearing impairment that severely affects the neuropsychological testing
* Visual impairment that severely affects the neuropsychological testing

Where it's running

• Department of Anesthesiology and Operative Intensive Care Medicine Berlin (CCM, CVK), Charité - Universitätsmedizin Berlin
  Berlin, Germany Recruiting
• Irmgard Landgraf
  Berlin, Germany Not yet recruiting

Study contacts

• Study coordinator: Claudia Spies, MD, Prof.
• Email: claudia.spies@charite.de
• Phone: +49 30 450 5510 01

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Tau changes after hip or knee replacement surgery

  Researchers will see if brain tau changes after hip or knee surgery and whether these changes relate to inflammation and thinking abilities.

  Recruiting Uppsala University Hospital · Uppsala · NCT07871487

• Risk of delirium and cognitive problems after TUR-P in older adults

  This study tests whether certain perioperative factors can predict delirium and postoperative cognitive dysfunction in people aged 65 and older undergoing transurethral resection.

  Recruiting Muğla Sıtkı Koçman University · Muğla · NCT07719712

• POCD after major gynecologic surgery in adults

  This study tests how often early postoperative cognitive dysfunction occurs after major gynecologic surgery and what perioperative factors are linked to it.

  Recruiting Kocaeli City Hospital · İzmit, Kocaeli · NCT07589348

• Optic nerve ultrasound to track brain pressure and thinking after Bentall surgery

  This project will test whether bedside ultrasound measurements of the optic nerve sheath before, during, and after elective Bentall surgery can help predict changes in thinking and memory in adult patients.

  Recruiting Bursa Yuksek Ihtisas Training and Research Hospital · Bursa, Yıldırım · NCT07452367

• Remimazolam versus Midazolam for sedation and early thinking recovery in older adults having orthopedic surgery

  This will test whether remimazolam or midazolam gives better sedation and faster early recovery of thinking and memory for people 65 and older undergoing orthopedic surgery with regional anesthesia.

  Recruiting Phase 3 Romanian Society for Enteral and Parenteral Nutrition · Bucharest · NCT07113483

• Assessing brain activity patterns to predict postoperative delirium

  This study is testing if monitoring brain activity during head and neck or plastic surgery can help predict if patients will experience confusion or memory problems afterwards.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06761573

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.