Using Valacyclovir to Manage Pain from Acute Apical Abscesses

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of a treatment regimen combining valacyclovir and antibiotics for managing pain associated with acute apical abscesses. It will involve 250 participants who will be randomly assigned to receive either the combination treatment or antibiotics alone. Preoperative and postoperative imaging will be conducted using cone beam computed tomography (CBCT) to assess pain levels and healing outcomes. The study seeks to address the viral component of endodontic infections to improve patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient must be ≥ 18-year-old
* Patient must be systemically healthy; American Society of Anesthesiologists (ASA) Class I or II
* Patient must exhibit clinical evidence of pulp necrosis and acute apical abscess
* Patient must present with radiographic
* signs of apical disease either by
* periapical radiography or cone-beam
* computed tomography
* Patient consented to receive conventional pulpal debridement, incision and drainage at the end of the study
* Persistent pain of moderate or higher level (\>4) was the main inclusion criterion. Pain assessed as follows: 0 defined as no pain, 1-3 as mild pain, 4-6 as moderate pain, and 7-10 as severe pain

Exclusion Criteria:

* Smokers (more than 10 cigarettes per day)
* External or internal tooth resorption
* Marginal periodontitis
* Pregnant or nursing mothers (hormonal factors may influence the periapical condition)
* Documented allergic or adverse reactions to amoxicillin or valacyclovir
* Teeth with unusual anatomy or inaccurate clinical diagnosis on the day of treatment (i.e., partially necrotic pulp)
* Patients currently taking antibiotics or antiviral medications

Where it's running

• UCSF Dental
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Mike Sabeti, DDS — University of California, San Francisco
• Study coordinator: Mike Sabeti, DDS
• Email: Mike.Sabeti@ucsf.edu
• Phone: 415-476-0822

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.