Understanding how steroid exposure affects eye pressure and glaucoma
Elucidating the molecular changes of the outflow pathway extracellular matrix that regulate outflow facility in steroid-induced ocular hypertension and open angle glaucoma
This study is looking at how changes in the eye's structure can raise pressure inside the eye, which is a problem for people with open angle glaucoma, and it’s exploring whether a treatment called tPA can help lower that pressure and improve care for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Suny Downstate Medical Center NIH-funded |
| Lab location | 1 site (Brooklyn, United States) |
| Project ID | NIH-11028857 on NIH RePORTER |
What this research studies
This research investigates how elevated intraocular pressure (IOP), a key risk factor for open angle glaucoma (OAG), is influenced by the extracellular matrix (ECM) in the eye. It focuses on the trabecular meshwork (TM) cells, which are crucial for regulating aqueous humor outflow. The study aims to identify how steroid exposure and genetic factors disrupt the ECM, leading to increased IOP. By exploring the potential of tissue plasminogen activator (tPA) to reverse these changes, the research seeks to restore normal eye pressure and improve treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with open angle glaucoma or those experiencing elevated eye pressure due to steroid treatment.
Not a fit: Patients with other forms of glaucoma or those not affected by elevated intraocular pressure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively lower eye pressure in patients with glaucoma or those at risk due to steroid use.
How similar studies have performed: Previous research has shown promise in using similar approaches to address elevated IOP, indicating potential for success in this area.
Where this research is happening
Brooklyn, United States
- Suny Downstate Medical Center — Brooklyn, United States (Active)
Researchers
- Principal investigator: Danias, John — Suny Downstate Medical Center
- Study coordinator: Danias, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.