Investigating the role of a specific microRNA in eye pressure regulation related to glaucoma.
Official title: MIR182 and Ocular Hypertension.
Funded at Augusta University · NIH-10770536 · Data updated 2026-11-12
This study is looking at how a tiny molecule called miR-182-5p affects eye pressure in people with primary open-angle glaucoma, hoping to find new ways to help manage the condition by comparing its levels in the fluid of affected eyes to those in healthy ones.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $192,500 |
| NIH project number | 5R21EY033961-02 |
| Project ID | NIH-10770536 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with primary open-angle glaucoma, regardless of their intraocular pressure levels.
✕Less likely to help
Patients with other types of glaucoma or those without any form of glaucoma may not benefit from this research.
What this research studies
This research focuses on understanding how the microRNA known as miR-182-5p influences intraocular pressure (IOP) in patients with primary open-angle glaucoma (POAG). By examining the expression levels of miR-182-5p in the aqueous humor of glaucomatous eyes compared to healthy controls, the study aims to uncover its role in the cellular functions of eye tissues involved in fluid drainage. The approach includes analyzing genetic variations associated with POAG and their impact on miR-182-5p expression, which could lead to new therapeutic strategies for managing glaucoma.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that specifically target the mechanisms of glaucoma, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the role of microRNAs in glaucoma, indicating that this approach has potential for success.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Liu, Yutao — Augusta University
- Study coordinator: Liu, Yutao
Related research
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Understanding how sudden eye pressure changes affect the optic nerve in living human eyes
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.