Investigating how glucocorticoids affect eye pressure and glaucoma risk
Official title: Glucocorticoids, ocular hypertension and glaucoma
Funded at University of North Texas Hlth Sci Ctr · NIH-10914820 · Data updated 2026-11-12
This study is looking at how certain medications for inflammation can raise eye pressure and increase the risk of glaucoma in some people, and it aims to find out if genetics play a role in who might be more affected, so we can help keep those at risk safer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Texas Hlth Sci Ctr NIH-funded |
| Lab location | 1 site (Fort Worth, United States) |
| Project start | September 30, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $557,079 |
| NIH project number | 5R01EY030967-05 |
| Project ID | NIH-10914820 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who are currently receiving glucocorticoid therapy and may be at risk for ocular hypertension.
✕Less likely to help
Patients who do not use glucocorticoids or have no history of ocular hypertension will likely not benefit from this research.
What this research studies
This research focuses on understanding how glucocorticoids, which are commonly prescribed anti-inflammatory medications, can lead to increased eye pressure and the risk of glaucoma in some patients. The study aims to identify genetic factors that may make certain individuals more susceptible to these side effects. By examining the molecular mechanisms involved, the researchers hope to uncover why some patients develop ocular hypertension while others do not. This could lead to better monitoring and prevention strategies for those at risk.
Why it matters
Potential benefit: If successful, this research could help identify patients at risk for glaucoma due to glucocorticoid use, potentially preventing vision loss.
How similar studies have gone: Previous studies have indicated a genetic component to susceptibility for glucocorticoid-induced ocular hypertension, suggesting that this research could build on established findings.
Where this research is happening
-
University of North Texas Hlth Sci Ctr
Fort Worth, United States Active
Researchers
- Principal investigator: Clark, Abbot Frederick — University of North Texas Hlth Sci Ctr
- Study coordinator: Clark, Abbot Frederick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.