Understanding how glucocorticoids can cause increased eye pressure
Official title: Elucidating novel mechanisms for glucocorticoid-induced ocular hypertension
Funded at Massachusetts Eye and Ear Infirmary · NIH-10755718 · Data updated 2026-11-12
This study is looking at how certain eye injections can cause high pressure in the eyes, which might lead to vision problems, and it aims to find out if some people are more at risk because of their genes, so we can better understand and treat this issue for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Eye and Ear Infirmary NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2020 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $347,927 |
| NIH project number | 5R01EY031027-05 |
| Project ID | NIH-10755718 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have received intravitreal glucocorticoid injections and may be experiencing or at risk for increased intraocular pressure.
✕Less likely to help
Patients who have not received glucocorticoid injections or do not have a history of ocular hypertension may not benefit from this research.
What this research studies
This research investigates the mechanisms behind glucocorticoid-induced ocular hypertension, a condition that can lead to vision loss. It aims to identify genetic factors that contribute to this complication by analyzing the genetic makeup of patients who have received glucocorticoid injections in their eyes. The study will involve examining specific cells in the eye and performing advanced genetic testing to uncover variations that may increase the risk of elevated eye pressure. By understanding these mechanisms, the research hopes to improve patient outcomes and tailor treatments more effectively.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and management strategies for patients at risk of glucocorticoid-induced ocular hypertension.
How similar studies have gone: Previous research has indicated that genetic factors play a role in ocular hypertension, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Massachusetts Eye and Ear Infirmary
Boston, United States Active
Researchers
- Principal investigator: Sobrin, Lucia — Massachusetts Eye and Ear Infirmary
- Study coordinator: Sobrin, Lucia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.