Understanding how glucocorticoids can cause increased eye pressure
Elucidating novel mechanisms for glucocorticoid-induced ocular hypertension
This study is looking at how certain eye injections can cause high pressure in the eyes, which might lead to vision problems, and it aims to find out if some people are more at risk because of their genes, so we can better understand and treat this issue for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Eye and Ear Infirmary NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10755718 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind glucocorticoid-induced ocular hypertension, a condition that can lead to vision loss. It aims to identify genetic factors that contribute to this complication by analyzing the genetic makeup of patients who have received glucocorticoid injections in their eyes. The study will involve examining specific cells in the eye and performing advanced genetic testing to uncover variations that may increase the risk of elevated eye pressure. By understanding these mechanisms, the research hopes to improve patient outcomes and tailor treatments more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received intravitreal glucocorticoid injections and may be experiencing or at risk for increased intraocular pressure.
Not a fit: Patients who have not received glucocorticoid injections or do not have a history of ocular hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and management strategies for patients at risk of glucocorticoid-induced ocular hypertension.
How similar studies have performed: Previous research has indicated that genetic factors play a role in ocular hypertension, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts Eye and Ear Infirmary — Boston, United States (Active)
Researchers
- Principal investigator: Sobrin, Lucia — Massachusetts Eye and Ear Infirmary
- Study coordinator: Sobrin, Lucia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.