Condition

Primary Open Angle Glaucoma clinical trials and research

• 18Clinical trials
• 7NIH research projects
• 14Countries

Newest Primary Open Angle Glaucoma clinical trials

All recruiting trials (18)

• G01 Eye Drops for Glaucomatous Optic Neuropathy

  This trial tests whether G01 Eye Drops can help people with open-angle glaucoma who also have optic nerve injury.

  Recruiting at 9 sites Phase 2 Qingdao WanMing BioCell Pharmaceutics Co.,Ltd. · Beijing, Beijing Municipality and 8 other locations · NCT07777861

• Additive Physical Activity for Hypothyroidism in Older Women with Glaucoma and Fatty Liver

  We’re testing whether adding a treadmill-based exercise program to standard thyroid treatment helps improve health in older women who have subclinical hypothyroidism, glaucoma, and fatty liver.

  Recruiting Cairo University · Dokki, Giza Governorate · NCT07599241

• Lifestyle changes plus nightly CPAP for glaucoma in people with sleep apnea

  This test checks whether adding a low-calorie diet and regular walking to nightly CPAP lowers eye pressure in people with high‑pressure open‑angle glaucoma who also have obstructive sleep apnea and obesity.

  Recruiting Cairo University · Giza, Dokki · NCT07447011

• Direct Selective Laser Trabeculoplasty to reduce glaucoma medications

  This study will try Direct Selective Laser Trabeculoplasty (DSLT) to reduce the number of eye-drop medications in adults with medically controlled primary open-angle glaucoma or ocular hypertension.

  Recruiting The Eye Institute of West Florida · Largo, Florida · NCT07390890

• Hexiris MIST device to lower eye pressure in people with primary open-angle glaucoma

  This trial will test the Hexiris MIST device to see if it lowers eye pressure in adults 40 and older whose primary open-angle glaucoma isn’t controlled by eye drops.

  Recruiting at 5 sites Hexiris Inc · Dieppe, New Brunswick and 4 other locations · NCT07358650

• PRESERFLO MicroShunt XI: patient experience follow-up after implantation for open-angle glaucoma

  A single-arm, post-market follow-up study to see how the PRESERFLO MicroShunt XI performs and whether it remains safe in adults with primary open angle glaucoma who aren’t controlled on medications.

  Recruiting at 10 sites Santen SAS · Vienna and 11 other locations · NCT07235592

• Direct selective laser trabeculoplasty to lower eye pressure in untreated open-angle glaucoma

  This study will try direct selective laser trabeculoplasty (DSLT) to lower eye pressure by more than 20% without glaucoma medications over six months in adults newly diagnosed with open-angle glaucoma or ocular hypertension.

  Recruiting Shafer Vision Institute · Plymouth Meeting, Pennsylvania · NCT07076303

• Assessing the safety and effectiveness of a glaucoma gel stent implantation

  This study is testing a new gel stent for treating glaucoma to see if it works well and is safe for people over 45 who haven't had success with other treatments.

  Recruiting at 25 sites Phase 3 AbbVie · Glendale, Arizona and 28 other locations · NCT06822738

• Electrical stimulation treatment for visual field defects in glaucoma patients

  This study is testing if a new electrical stimulation treatment can help people with glaucoma keep their vision from getting worse while they continue using their regular eye drops.

  Recruiting Okuvision GmbH · Mainz · NCT06682962

• Home IOP telemonitoring with smartphone support for open-angle glaucoma

  This trial tests whether home intraocular pressure monitoring plus a smartphone-based management plan helps people with newly diagnosed open-angle glaucoma control eye pressure better than a smartphone-based plan alone.

  Recruiting The University of Hong Kong · Wong Chuk Hang · NCT05940623

• Nanodropper microdrop delivery for primary open-angle glaucoma and ocular hypertension

  This test will see if Nanodropper microdrops of glaucoma medicines lower eye pressure as well as standard eye drops for adults with primary open-angle glaucoma or ocular hypertension.

  Recruiting 59th Medical Wing · Lackland Air Force Base, Texas · NCT05844384

• Evaluating standalone canaloplasty for glaucoma treatment

  This study is testing two different devices for a procedure called canaloplasty to see which one works better for people with mild to moderate glaucoma.

  Recruiting at 5 sites Nova Eye, Inc. · Düsseldorf and 4 other locations · NCT05786196

• Cataract surgery combined with canaloplasty for glaucoma patients

  This study is testing whether combining cataract surgery with a special glaucoma procedure can help people with mild to moderate glaucoma manage their eye pressure better than just cataract surgery alone.

  Recruiting at 4 sites Nova Eye, Inc. · Sugar Land, Texas and 3 other locations · NCT05564091

• Comparing XEN Glaucoma Gel Stent and Trabeculectomy for Glaucoma Treatment

  This study is testing whether a new minimally invasive glaucoma implant works better than traditional surgery for improving vision in people with open angle glaucoma.

  Recruiting Paracelsus Medical University · Salzburg · NCT05439161

• Assessing the Glycocalyx in Patients with Primary Open-angle Glaucoma

  This study is testing a special imaging technique to see if the tiny blood vessels in people with primary open-angle glaucoma are working properly compared to those without eye problems.

  Recruiting Fondation Ophtalmologique Adolphe de Rothschild · Paris · NCT05264818

• Evaluation of Hydrus Microstent after cataract surgery for glaucoma

  This study is testing how well the Hydrus Microstent works for people with glaucoma after they have cataract surgery to see if it stays in place and improves their eye health over two years.

  Recruiting at 13 sites Alcon Research · Irvine, California and 21 other locations · NCT04553523

• Measuring retinal photoreceptor response to light stimulation

  This study is testing a new way to measure how light affects the eye's photoreceptors in healthy people and those with glaucoma or age-related macular degeneration to see if it can help track eye health.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT03921931

• Diagnostic innovations for detecting glaucoma in eyes with and without myopia

  This project tests imaging and vision tests to see if they can better detect glaucoma or its worsening in adults with or without myopia.

  Recruiting University of California, San Diego · La Jolla, California · NCT00221897

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Improving glaucoma risk predictions using diverse genetic data

  A glaucoma study uses genetic data from people of African, American, and European ancestry to build better risk scores and help with early detection.

  NIH research East Carolina University · Greenville, United States · NIH-11386975

• Multimodal AI to predict glaucoma progression and guide care

  A big-data AI tool uses eye images, scans, field tests, and health info to help predict who with open-angle glaucoma is at higher risk of vision loss so doctors can act sooner.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11365407

• Replacing damaged eye drainage cells to treat glaucoma

  This project is developing a cell-based treatment to replace lost drainage cells and help people with primary open-angle glaucoma keep eye pressure lower and protect vision.

  NIH research Iowa City VA Medical Center · Iowa City, United States · NIH-11175341

• Improving risk prediction for glaucoma in diverse populations

  This study is looking to improve how we predict the risk of primary open-angle glaucoma in people of African ancestry, so that they can get better early diagnosis and treatment options based on their unique genetic background.

  NIH research East Carolina University · Greenville, United States · NIH-11002782

• Using cell therapy to treat primary open angle glaucoma

  This study is testing a new cell therapy to help people with primary open angle glaucoma by using special stem cells to improve eye function and lower pressure, which could help prevent vision loss when regular treatments aren't enough.

  NIH research Iowa City VA Medical Center · Iowa City, United States · NIH-10995780

• Better genetic risk prediction for open-angle glaucoma

  This project will build more accurate genetic risk tools for people at risk of open-angle glaucoma by including more diverse ancestry groups in the analysis.

  NIH research East Carolina University · Greenville, United States · NIH-10879124

• Improving fairness in glaucoma risk estimation using artificial intelligence

  This study is working on a new AI tool to help better predict the risk of glaucoma, especially for people in diverse communities like African and Hispanic Americans, so that everyone can get fairer and more accurate eye care.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-10726928

Related topics

Quick answers

How many Primary Open Angle Glaucoma clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (7 trials), Germany (4 trials), Austria (3 trials), Spain (2 trials), United Kingdom (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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