Condition

Neoadjuvant Therapy clinical trials and research

• 53Clinical trials
• 22NIH research projects
• 1New in 30 days
• 10Countries

Newest Neoadjuvant Therapy clinical trials

All recruiting trials (53)

• MRD-guided postoperative monitoring and adaptive treatment for resectable NSCLC

  This study tests a personalized follow-up and treatment plan using ctDNA MRD testing and pathology to guide adjuvant therapy after surgery for stage IB-IIIA NSCLC treated with neoadjuvant immunotherapy.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality · NCT07894458

• Perioperative therapy with Retlirafusp alfa, Famitinib, and HAIC-GEMOX for locally advanced intrahepatic cholangiocarcinoma

  This trial tests whether a perioperative treatment combo (Retlirafusp alfa, famitinib, and HAIC-GEMOX) can help shrink or control locally advanced intrahepatic cholangiocarcinoma before surgery and support additional therapy afterward in adults.

  Recruiting Phase 2 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT07847710

• Interferon-gamma plus camrelizumab with chemotherapy before surgery for locally advanced esophageal squamous cell carcinoma

  This trial tests whether giving interferon-gamma with camrelizumab and chemotherapy before surgery helps patients with locally advanced esophageal squamous cell carcinoma.

  Recruiting at 2 sites Phase 2 Hefei Cancer Hospital of the Chinese Academy of Sciences · Hefei, Anhui and 1 other locations · NCT07787273

• Olaparib with Trastuzumab and Pertuzumab before surgery for older women with HER2-positive breast cancer

  This trial tests whether adding olaparib to standard HER2-targeted therapy can help older women with newly diagnosed, operable HER2-positive breast cancer before surgery.

  Recruiting Phase 4 Zhejiang Cancer Hospital · Hangzhou, Zhejiang · NCT07695259

• Firmonertinib given before surgery for EGFR-mutated NSCLC

  This study tests whether taking firmonertinib before and around surgery helps patients with resectable EGFR-mutated NSCLC see more tumor shrinkage before the operation.

  Recruiting Phase 2 Peking University Cancer Hospital & Institute · Beijing · NCT07622706

• Nimotuzumab plus Immunotherapy and Chemotherapy before surgery for locally advanced head and neck cancer

  This phase 2 trial tests whether adding nimotuzumab to immunotherapy and chemotherapy before surgery helps people with locally advanced head and neck squamous cell carcinoma.

  Recruiting Phase 2 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai · NCT07601737

• Digital music-and-biofeedback mind-body program during pre-surgery chemotherapy for breast cancer

  This trial tests a smartphone-delivered music and biofeedback mind-body program to help people with locally advanced breast cancer who are receiving neoadjuvant therapy.

  Recruiting Fudan University · Shanghai, Shanghai Municipality · NCT07541664

• Camrelizumab, chemotherapy and Ivarmacitinib before surgery for resectable esophageal squamous cell carcinoma

  This trial tests whether giving camrelizumab with chemotherapy and the JAK inhibitor Ivarmacitinib before surgery can improve outcomes for patients with locally advanced esophageal squamous cell carcinoma that can be removed by operation.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, China · NCT07505186

• FAP-targeted PET and near-infrared fluorescence imaging for resectable non-small cell lung cancer

  We are testing whether FAP-targeted PET and near-infrared fluorescence can help find residual tumor and guide surgery in people with stage II–IIIB resectable non-small cell lung cancer after neoadjuvant therapy.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality · NCT07498933

• Neoadjuvant fulzerasib followed by sintilimab plus platinum-doublet chemotherapy for resectable KRAS G12C-mutant NSCLC

  This will test whether giving fulzerasib first, then sintilimab with platinum-doublet chemotherapy before surgery helps people with resectable KRAS G12C‑mutant stage IB–IIIA non‑small cell lung cancer.

  Recruiting Phase 2 The First Affiliated Hospital of Guangzhou Medical University · Beijing and 2 other locations · NCT07492342

• Adding tislelizumab with or without the probiotic Probio-M9 to pre-surgery chemoradiation for pMMR/MSS locally advanced rectal cancer.

  This will see if adding the PD-1 drug tislelizumab, with or without the probiotic Probio-M9, to standard pre-surgery chemoradiation helps adults with pMMR/MSS locally advanced rectal cancer.

  Recruiting Phase 2 Seventh Medical Center of PLA General Hospital · Beijing, Beijing Municipality · NCT07458529

• Effect of pre-surgery (neoadjuvant) therapy on surgical outcomes in colorectal cancer

  We will test whether pre-surgery (neoadjuvant) therapy changes tiny blood vessels, increases tissue scarring, and raises the risk of wound and other perioperative complications in adults having colorectal cancer surgery.

  Recruiting Osijek University Hospital · Osijek · NCT07422974

• Iparomlimab and Tuvonralimab plus lenvatinib before kidney-sparing surgery for clear cell kidney cancer

  This will test whether giving Iparomlimab and Tuvonralimab (QL1706) together with lenvatinib before surgery helps people with localized clear cell kidney cancer (T1–T2) who need but may have difficulty getting kidney-preserving surgery because of a high R.E.N.A.L. score.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou · NCT07389629

• Predicting outcomes of pre-surgery treatment for non-small cell lung cancer

  This project will try to use clinical, imaging, and molecular data to predict which patients with non-small cell lung cancer will respond to neoadjuvant chemo‑immunotherapy before surgery.

  Recruiting at 2 sites Tongji Hospital · Wuhan, Hubei and 1 other locations · NCT07388771

• Pucotenlimab plus vorolanib before surgery for clear cell kidney cancer

  This trial tests whether giving pucotenlimab with vorolanib before surgery can shrink localized clear cell kidney tumors and make kidney-sparing surgery easier for adults with difficult-to-remove tumors.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Other (Non U.s.) · NCT07386158

• Neoadjuvant therapy for early triple-negative breast cancer using QL1706 plus chemotherapy guided by response

  This study tests if adding QL1706 (a PD-1/CTLA-4 blocker) to chemotherapy before surgery can shrink early triple-negative breast tumors and spare some patients from anthracyclines.

  Recruiting Phase 2 Tianjin Medical University Cancer Institute and Hospital · Tianjin · NCT07372079

• Ivonescimab in Neoadjuvant NSCLC: Testing a PD-1/VEGF Bi-specific

  This study tests Ivonescimab, a PD-1/VEGF bispecific antibody, in people with non-small cell lung cancer to see if it works better or has different safety than standard PD-1 inhibitors before surgery.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality · NCT07359040

• Sintilimab plus bevacizumab biosimilar before surgery for resectable liver cancer

  This trial will test whether giving sintilimab together with a bevacizumab biosimilar before surgery helps people with resectable hepatocellular carcinoma beyond the Milan criteria.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT07324824

• Multi-omics blood and CT monitoring for early detection of lung cancer recurrence after neoadjuvant therapy and surgery

  This project tests whether combining blood-based multi-omics (metabolomics and cfDNA), CT radiomics, and AI can noninvasively detect early recurrence after surgery in NSCLC patients treated with neoadjuvant immunotherapy.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality · NCT07291921

• Circulating microRNA changes to predict neoadjuvant chemotherapy response in breast cancer.

  This will test whether changes in blood microRNA levels before and after chemotherapy can help predict who will have a strong tumor response to neoadjuvant chemotherapy for breast cancer.

  Recruiting Atlas University · Istanbul · NCT07289282

• Envafolimab with albumin-bound paclitaxel and carboplatin before surgery for resectable locally advanced esophageal squamous cell carcinoma

  This study tests whether adding envafolimab to albumin-bound paclitaxel and carboplatin before surgery helps people with resectable locally advanced esophageal squamous cell carcinoma.

  Recruiting Phase 2 Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07266493

• Ivonescimab plus chemotherapy before surgery for resectable esophageal squamous cell cancer

  This study tests whether giving Ivonescimab together with chemotherapy before esophageal cancer surgery helps patients see better outcomes than surgery alone.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07244978

• Neoadjuvant radiotherapy plus SOX chemotherapy with Iparomlimab and Tuvonralimab for resectable gastric and gastroesophageal junction adenocarcinoma

  This trial will test whether adding radiotherapy to pre-surgery SOX chemotherapy plus two immunotherapy drugs (Iparomlimab and Tuvonralimab) helps people with resectable, HER2‑negative gastric or gastroesophageal junction cancer.

  Recruiting Phase 2 Daping Hospital and the Research Institute of Surgery of the Third Military Medical University · Chongqing, Other (Non U.s.) · NCT07165847

• Long-course chemoradiation or short-course radiation with CAPOX, PD-1 antibody, and celecoxib for MSS locally advanced rectal cancer

  This trial tests whether adding a PD‑1 immune drug and the anti‑inflammatory celecoxib to standard CAPOX chemotherapy with either long- or short-course radiotherapy helps people with MSS locally advanced rectal cancer achieve a complete response before surgery.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT07150949

• Sleeve lobectomy after neoadjuvant therapy for non-small cell lung cancer

  This will see if minimally invasive sleeve lobectomy (VATS or RATS) works as well or better than open thoracotomy for adults with non-small cell lung cancer who received pre-surgery (neoadjuvant) treatment.

  Recruiting Shanghai Chest Hospital · Shanghai, Shanghai Municipality · NCT07135856

• Neoadjuvant tislelizumab plus nab‑paclitaxel before radical nephroureterectomy for upper tract urothelial carcinoma

  This will test whether giving the PD‑1 drug tislelizumab together with nab‑paclitaxel before surgery helps people with non‑metastatic upper tract urothelial carcinoma.

  Recruiting Phase 2 Tianjin Medical University Second Hospital · Tianjin, Outside U.S. · NCT07126119

• Neoadjuvant tislelizumab plus nab‑paclitaxel before kidney‑sparing distal ureterectomy for ureteral cancer

  This will try giving people with non‑metastatic ureteral cancer two to three cycles of tislelizumab plus nab‑paclitaxel before a kidney‑sparing distal ureterectomy to see if tumor response improves and the treatment is tolerable.

  Recruiting Phase 2 Tianjin Medical University Second Hospital · Tianjin, Outside U.S. · NCT07125547

• Tislelizumab plus FLOT given before surgery for operable esophagus or stomach adenocarcinoma

  This trial tests whether adding the immunotherapy drug tislelizumab to FLOT chemotherapy given before surgery helps people with locally advanced, resectable esophagus or stomach adenocarcinoma shrink tumors and better tolerate treatment.

  Recruiting at 2 sites Phase 1 Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest · Frankfurt and 3 other locations · NCT07059299

• Neoadjuvant cadonilimab plus perioperative SOX for diffuse or mixed locally advanced stomach/GEJ cancer

  This will test whether adding cadonilimab to perioperative SOX chemotherapy helps people with diffuse or mixed locally advanced stomach or gastroesophageal junction adenocarcinoma.

  Recruiting at 4 sites Phase 3 Lanzhou University Second Hospital · Lanzhou, Gansu and 3 other locations · NCT06949033

• Comparing two treatment combinations for advanced gastric cancer

  This study is testing if adding a new drug called apatinib to standard treatments can help people with advanced gastric cancer get better results and stay safe during treatment.

  Recruiting at 4 sites Phase 3 Lanzhou University Second Hospital · Lanzhou, Gansu and 3 other locations · NCT06925243

• SNF-guided neoadjuvant therapy for HR-positive/HER2-negative breast cancer

  This trial will test whether giving chemotherapy selected by SNF subtype with targeted drugs before surgery helps people with early or locally advanced HR-positive/HER2-negative breast cancer.

  Recruiting Phase 3 Fudan University · Shanghai, Shanghai Municipality · NCT06913777

• Urine protein markers to predict and monitor response to pre-surgery therapy in colorectal cancer.

  This project will test whether urine proteins can predict and track how people with locally advanced colorectal cancer respond to neoadjuvant (pre-surgery) therapy.

  Recruiting Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Chaoyang District · NCT06904677

• Combining chemotherapy with pyrotinib and trastuzumab for HER2-positive breast cancer

  This study is testing whether combining chemotherapy with two targeted drugs, pyrotinib and trastuzumab, can help people with HER2-positive breast cancer respond better to treatment before surgery.

  Recruiting Phase 2 First Affiliated Hospital of Zhejiang University · Hangzhou · NCT06832904

• Short-course radiotherapy followed by AK112 and CAPOX for advanced rectal cancer

  This study is testing a new treatment plan that combines short radiation therapy with two medications for people with advanced rectal cancer to see if it works better than the usual treatments.

  Recruiting Phase 2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Hubei · NCT06802666

• Using question prompts to help breast cancer patients before chemotherapy

  This study is testing whether a list of questions can help breast cancer patients feel more informed and less anxious before starting chemotherapy.

  Recruiting Region Örebro County · Uppsala, Region Uppsala and 2 other locations · NCT06777420

• Comparing total neoadjuvant therapy with surgery for rectal cancer treatment

  This study is testing if rectal cancer patients who respond well to a new treatment can skip surgery and just be monitored to see how they do compared to those who have surgery right away.

  Recruiting Phase 2/3 National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos · Vilnius · NCT06758830

• MRI-based radiomics to predict pathology response after neoadjuvant therapy in head and neck cancer

  This study tests whether MRI-derived radiomics features can predict which patients with head and neck squamous cell carcinoma will achieve a complete pathological response after neoadjuvant chemotherapy and PD-1–inhibitor therapy.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT06755567

• Neoadjuvant Cemiplimab + Dupilumab in Early-Stage NSCLC

  This study tests whether giving cemiplimab with dupilumab before surgery can be safe and help shrink tumors in people with early-stage non-small cell lung cancer.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec and 1 other locations · NCT06743581

• Combination of immunotherapy and chemotherapy for advanced lung cancer

  This study is testing if a new combination of immunotherapy and chemotherapy can help people with advanced lung cancer do better than the usual treatment.

  Recruiting Phase 3 Sun Yat-sen University · Guangzhou, Guangdong · NCT06734702

• Reducing sitting time and increasing daily activity during cancer treatment

  This project will try a digital self-management program plus physiotherapist support to help people with breast, prostate, or colorectal cancer who are starting neo- or adjuvant treatment sit less and feel better during and after treatment.

  Recruiting at 2 sites Mälardalen University · Uppsala and 1 other locations · NCT06719206

• Skipping axillary surgery when lymph nodes look normal on ultrasound after preoperative chemotherapy

  This trial tests whether skipping axillary lymph node surgery after neoadjuvant chemotherapy is safe for breast cancer patients whose lymph nodes look normal on ultrasound.

  Recruiting Phase 3 Seoul National University Hospital · Seoul · NCT06704945

• Exploring PD-1 therapy duration for rectal cancer treatment

  This study is testing how long PD-1 therapy should be given to people with stage II-III rectal cancer to see if it helps them have the best chance of a complete response before surgery.

  Recruiting Xijing Hospital · Xi'an, Shaanxi · NCT06613165

• Cadonilimab with paclitaxel micelles and cisplatin before surgery for locally advanced esophageal squamous cancer

  This trial will test whether giving cadonilimab together with paclitaxel polymeric micelles and cisplatin before surgery helps people with locally advanced esophageal squamous cell carcinoma.

  Recruiting Phase 2 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT06356688

• Neoadjuvant therapy for locally advanced esophageal squamous cell carcinoma

  This study is testing two different treatment plans for people with advanced esophageal cancer to see which one works better and is safer before surgery.

  Recruiting Phase 2/3 Army Medical Center of PLA · Chongqing, None Selected · NCT06354530

• CAPOX plus PD-1 antibody (toripalimab) with or without short-course radiotherapy for MSS locally advanced rectal cancer

  This trial will try toripalimab combined with CAPOX chemotherapy, with or without a short course of radiotherapy, to see if it increases complete response rates in adults with MSS locally advanced rectal cancer.

  Recruiting Phase 2 Fudan University · Shanghai · NCT06281405

• Combining camrelizumab with chemotherapy for lung cancer treatment

  This study is testing if combining a new drug called camrelizumab with chemotherapy can help people with certain types of lung cancer before surgery.

  Recruiting Phase 2 Shandong Cancer Hospital and Institute · Jinan, Shandong · NCT06241807

• Combining Pembrolizumab with Chemotherapy for Advanced Head and Neck Cancer

  This study is testing whether adding a drug called pembrolizumab to standard chemotherapy can help people with advanced head and neck cancer respond better to treatment.

  Recruiting Phase 3 Beijing Tongren Hospital · Beijing, Beijing Municipality · NCT06102395

• Genomics-guided precision oncology for early high-risk breast cancer

  This study is testing if analyzing the genes of early-stage breast cancer tumors can help find better treatment options for patients who don't respond well to standard chemotherapy.

  Recruiting at 11 sites German Cancer Research Center · Augsburg and 11 other locations · NCT05906407

• Intense hormone therapy before surgery for advanced prostate cancer

  This study is testing whether a stronger hormone treatment before surgery can help men with advanced prostate cancer do better than the usual hormone therapy.

  Recruiting Phase 2 The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT05406999

• Using biopsies to improve diagnosis of rectal cancer after treatment

  This study is testing if using special biopsy techniques can help doctors more accurately determine if rectal cancer patients have fully responded to treatment before surgery.

  Recruiting Beijing Chao Yang Hospital · Beijing, Beijing Municipality · NCT04743102

• Improving fitness during chemotherapy for liver cancer patients

  This study is testing a 16-week program that combines exercise, nutrition, and support to see if it helps liver cancer patients feel fitter during chemotherapy and before surgery compared to those who only get support right before surgery.

  Recruiting Institut Investigacio Sanitaria Pere Virgili · Tarragona · NCT04520737

• Less invasive axillary treatment for breast cancer after chemotherapy

  This study tests if a less invasive way to treat breast cancer after chemotherapy can keep women safe and improve their quality of life compared to more invasive methods.

  Recruiting at 35 sites Maastricht University Medical Center · 's-Hertogenbosch and 34 other locations · NCT04486495

• Neoadjuvant therapy for colorectal cancer using toripalimab with or without celecoxib

  This study is testing if adding celecoxib to the immunotherapy toripalimab can help people with certain types of colorectal cancer feel better before surgery.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT03926338

NIH-funded research (22)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Antibody-drug conjugates for ovarian cancer with poor response to platinum therapy

  A Mayo Clinic team is testing targeted antibody-drug conjugates to help people with advanced high-grade ovarian cancer who did not respond well to standard platinum-based treatment.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11421328

• A new telomere-targeted drug to boost surgery for early liver cancer

  A first-in-class drug given before surgery may reduce recurrence for people with early-stage liver cancer by targeting cancer cells with a special enzyme.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11406311

• Total Neoadjuvant Therapy for Borderline or Locally Advanced Pancreatic Cancer

  A multi-part treatment approach tests giving all chemotherapy and targeted radiotherapy before surgery to help patients with tough-to-remove pancreatic cancer become eligible for curative surgery.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11397470

• Enhancing pre-surgery therapy to prevent breast cancer recurrence

  A new program tests ways to boost chemotherapy given before surgery to lower the chance that breast cancer comes back, especially focusing on groups that have had worse outcomes.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11389265

• Improving response prediction to pre-surgery therapy in pancreatic cancer

  A doctor-led program will study molecular clues from pancreatic cancer patients to better predict who will respond to chemotherapy before surgery.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11377720

• Advancing 3D photoacoustic breast imaging to predict therapy response

  A new 3D photoacoustic breast imaging method will help doctors see early how breast cancers respond to neoadjuvant therapy.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11365086

• Dose levels of aerobic exercise during cancer therapy for rectal cancer

  A personalized exercise plan is tested to see how different amounts of aerobic training affect how well people with locally advanced rectal cancer tolerate their treatment.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11325432

• Radiomic clues to predict who can avoid rectal cancer surgery

  A study using MRI-based texture patterns to spot rectal cancer patients who might respond so well to neoadjuvant therapy that surgery could be avoided.

  NIH research Emory University · Atlanta, United States · NIH-11319816

• Precision pre-surgery therapy for high-risk PTEN-loss prostate cancer

  This grant plans a targeted, pre-surgical treatment for men with high-risk localized prostate cancer who have PTEN loss, using intensified hormone therapy plus an AKT inhibitor before surgery.

  NIH research Portland VA Medical Center · Portland, United States · NIH-11291871

• MRI and blood tests to predict response to pre-surgery therapy in rectal cancer

  This project combines MRI scans and blood tests to find which people with locally advanced rectal cancer will respond well to treatment given before surgery.

  NIH research Stanford University · Stanford, United States · NIH-11262854

• Boosting pre-surgery treatment to prevent breast cancer from returning

  This project tries targeted drugs plus pre-surgery chemotherapy and computer-guided predictions to help people with triple-negative breast cancer, including Black and Hispanic women, reduce hidden cancer and lower the chance of relapse.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11177949

• Intensive pre-surgery treatment for borderline and locally advanced pancreatic cancer

  This gives strong combination chemotherapy followed by high-dose targeted radiation before surgery for people with borderline resectable or locally advanced pancreatic cancer to shrink tumors and make surgery possible.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11169814

• Understanding Pancreatic Cancer's Response to Pre-Surgery Treatment

  This project aims to find better ways to tell if chemotherapy given before surgery is working for people with localized pancreatic cancer.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11141863

• Improving Breast Cancer Imaging to Predict Treatment Response

  This project is developing a new imaging method to help doctors understand how breast cancer patients are responding to their initial treatments.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11124881

• Targeted therapy for aggressive prostate cancer with PTEN loss

  This study is testing a new treatment for men with high-risk localized prostate cancer that has lost a specific gene, aiming to combine hormone therapy with a special drug before surgery to help shrink the cancer and improve outcomes.

  NIH research Portland VA Medical Center · Portland, United States · NIH-11118672

• Identifying patients with rectal cancer who respond well to neoadjuvant therapy

  This study is looking at new ways to use advanced MRI scans to find out if rectal cancer patients have responded well to their treatment before surgery, which could help some people skip surgery altogether and live better lives.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11089488

• Using advanced MRI to track treatment response in bladder cancer

  This study is looking to develop a new way to see how well people with muscle invasive bladder cancer are responding to their chemotherapy treatment, using a special type of MRI that can show changes in how the cancer is behaving, so doctors can better tailor treatments to each patient’s needs.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11061082

• Effects of aerobic training on cancer treatment tolerability in rectal cancer patients

  This study is looking at how different amounts of aerobic exercise can help people with locally advanced rectal cancer feel better and handle their treatment more easily, and it’s designed for patients who are about to start their cancer therapy.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11056086

• Using MRI and blood tests to understand treatment responses in rectal cancer

  This study is looking at how MRI scans and blood tests can help doctors figure out which patients with rectal cancer will respond well to treatment before surgery, so they can tailor the best plan for each person—possibly helping some avoid surgery altogether while making sure others get the care they really need.

  NIH research Stanford University · Stanford, United States · NIH-11031929

• Predicting how pancreatic cancer responds to treatment before surgery

  This study is looking to find out how different types of pancreatic tumors react to chemotherapy given before surgery, so we can better personalize treatment for patients and improve their outcomes.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-10929448

• New treatment approach for difficult-to-surgically-remove pancreatic cancer

  This study is looking at a new way to treat patients with tough-to-reach pancreatic cancer by giving them chemotherapy and radiation before surgery to help shrink the tumors and make surgery more successful.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10908415

• Improving breast imaging to better predict treatment response in breast cancer patients

  This study is testing a new imaging system that helps doctors see how well treatment is working for breast cancer patients without needing invasive procedures or exposing them to radiation, making it easier to create personalized treatment plans.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-10880685

Related topics

Quick answers

How many Neoadjuvant Therapy clinical trials are recruiting right now?

53, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in China (42 trials), Sweden (2 trials), Germany (2 trials), Spain (1 trial), Croatia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 24, Phase 3: 6, Phase 2/3: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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