Less invasive axillary treatment for breast cancer after chemotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on women with node positive breast cancer who are receiving neoadjuvant systemic therapy. It aims to evaluate the oncologic safety and quality of life impacts of less invasive axillary staging and treatment compared to more invasive methods. Patients will complete surveys to assess their quality of life at diagnosis, and again at one and five years post-diagnosis. Data will be collected from patient records and analyzed to inform national guidelines and support shared decision-making in treatment options.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female patient with unilateral invasive breast cancer and cN1-3
* Pathologically proven positive axillary lymph node
* Planned to undergo neoadjuvant chemotherapy (± immunotherapy), followed by staging and treatment of the breast and axilla

Exclusion Criteria:

* Clinically node negative breast cancer before NST
* Bilateral invasive breast cancer
* Neoadjuvant endocrine therapy
* Distant metastases (including oligometastatic disease)
* History of invasive breast cancer
* Other malignancies, except for basal/squamous cell skin cancer, and in situ carcinoma of the cervix or breast
* Axillary surgery or radiotherapy before NST (this includes SLNB prior to NST)

Where it's running

• Jeroen Bosch Hospital
  's-Hertogenbosch, Netherlands Recruiting
• Northwest Clinics
  Alkmaar, Netherlands Recruiting
• The Netherlands Cancer Institute
  Amsterdam, Netherlands Recruiting
• Gelre Hospital
  Apeldoorn, Netherlands Recruiting
• Rijnstate Hospital
  Arnhem, Netherlands Recruiting
• Red Cross Hospital
  Beverwijk, Netherlands Recruiting

Study contacts

• Principal investigator: Marjolein Smidt, MD, PhD — Maastricht University Medical Center
• Study coordinator: Sabine de Wild, MD
• Email: s.dewild@maastrichtuniversity.nl
• Phone: +31433881574

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Neoadjuvant therapy for early triple-negative breast cancer using QL1706 plus chemotherapy guided by response

  This study tests if adding QL1706 (a PD-1/CTLA-4 blocker) to chemotherapy before surgery can shrink early triple-negative breast tumors and spare some patients from anthracyclines.

  Recruiting Phase 2 Tianjin Medical University Cancer Institute and Hospital · Tianjin · NCT07372079

• Circulating microRNA changes to predict neoadjuvant chemotherapy response in breast cancer.

  This will test whether changes in blood microRNA levels before and after chemotherapy can help predict who will have a strong tumor response to neoadjuvant chemotherapy for breast cancer.

  Recruiting Atlas University · Istanbul · NCT07289282

• Reducing sitting time and increasing daily activity during cancer treatment

  This project will try a digital self-management program plus physiotherapist support to help people with breast, prostate, or colorectal cancer who are starting neo- or adjuvant treatment sit less and feel better during and after treatment.

  Recruiting at 2 sites Mälardalen University · Uppsala and 1 other locations · NCT06719206

• Skipping axillary surgery when lymph nodes look normal on ultrasound after preoperative chemotherapy

  This trial tests whether skipping axillary lymph node surgery after neoadjuvant chemotherapy is safe for breast cancer patients whose lymph nodes look normal on ultrasound.

  Recruiting Phase 3 Seoul National University Hospital · Seoul · NCT06704945

• Targeted removal of lymph nodes in breast cancer patients after chemotherapy

  This study is testing a new way to remove lymph nodes in breast cancer patients after chemotherapy to see if it works better and is safer than the usual methods.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT04744506

• Gyrotonic exercise for elders with breast cancer and Behcet disease

  We’re testing whether a gyrotonic exercise program helps older people who have both Behcet disease and breast cancer.

  Recruiting Cairo University · Giza, Dokki · NCT07929116

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.