Predicting how pancreatic cancer responds to treatment before surgery
Official title: Improving response prediction to neoadjuvant therapy in pancreatic cancer
Funded at Dana-Farber Cancer Inst · NIH-10929448 · Data updated 2026-11-12
This study is looking to find out how different types of pancreatic tumors react to chemotherapy given before surgery, so we can better personalize treatment for patients and improve their outcomes.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $288,565 |
| NIH project number | 5K08CA286749-02 |
| Project ID | NIH-10929448 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with localized pancreatic cancer who are scheduled to receive neoadjuvant chemotherapy.
✕Less likely to help
Patients with metastatic pancreatic cancer or those who are not candidates for chemotherapy may not benefit from this research.
What this research studies
This research focuses on improving the prediction of how localized pancreatic cancer will respond to neoadjuvant chemotherapy, which is given before surgery. It aims to understand the molecular characteristics of pancreatic tumors that influence treatment response, particularly looking at different tumor subtypes. By analyzing patient samples and using advanced techniques like single-cell analysis, the research seeks to identify biomarkers that can help tailor treatment plans for better outcomes. Patients will be monitored over several months to assess their response to chemotherapy before surgical intervention.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for pancreatic cancer, potentially improving survival rates.
How similar studies have gone: Previous research has shown promise in using molecular profiling to predict treatment responses in various cancers, suggesting that this approach may also be effective for pancreatic cancer.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Singh, Harshabad — Dana-Farber Cancer Inst
- Study coordinator: Singh, Harshabad
Related research
Other NIH-funded projects on the same topics.
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Improving response prediction to pre-surgery therapy in pancreatic cancer
A doctor-led program will study molecular clues from pancreatic cancer patients to better predict who will respond to chemotherapy before surgery.
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Understanding Pancreatic Cancer's Response to Pre-Surgery Treatment
This project aims to find better ways to tell if chemotherapy given before surgery is working for people with localized pancreatic cancer.
-
Microbial Dysbiosis and Its Role in Pancreatic Cancer
A doctor-researcher team at Northwestern University is studying how gut bacteria influence pancreatic cancer and its response to immunotherapy to find new ways to help patients.
-
Targeting aberrant enhancer landscapes in pancreatic cancer
A patient-facing look at a project that aims to understand how pancreatic cancer changes its cell identity and what that means for treatment.
-
Exosome-based microRNA biomarkers for early, non-invasive detection of pancreatic cancer
A study to develop a blood test that uses tiny RNA signals in exosomes to detect pancreatic cancer early, aiming to help people at risk or with early disease.
-
Exosome-based microRNA biomarkers for early detection of pancreatic cancer
A patient-friendly look at a study using tiny blood-based RNA markers inside exosomes to catch pancreatic cancer early without invasive procedures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.