Effects of aerobic training on cancer treatment tolerability in rectal cancer patients
Dose-response of aerobic training during total neoadjuvant therapy for locally advanced rectal cancer
This study is looking at how different amounts of aerobic exercise can help people with locally advanced rectal cancer feel better and handle their treatment more easily, and it’s designed for patients who are about to start their cancer therapy.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11056086 on NIH RePORTER |
What this research studies
This research investigates how different amounts of aerobic training can affect the ability of patients with locally advanced rectal cancer to tolerate their cancer treatment. Patients will be randomly assigned to one of three groups, each receiving varying levels of aerobic exercise over approximately 32 weeks, starting before their treatment and continuing until just before surgery. The study aims to determine if increased aerobic activity can improve physical and psychological outcomes during total neoadjuvant therapy. By focusing on a specific cancer type and treatment regimen, the research seeks to fill a critical gap in understanding the role of exercise in cancer care.
Who could benefit from this research
Good fit: Ideal candidates for this research are inactive adults diagnosed with locally advanced rectal cancer who are about to begin total neoadjuvant therapy.
Not a fit: Patients who are already highly active or those with advanced cancer stages not eligible for total neoadjuvant therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could help improve the tolerability of cancer treatments, leading to better patient outcomes and potentially higher completion rates of prescribed therapies.
How similar studies have performed: Previous research has shown that aerobic training can improve treatment tolerability in various cancer populations, suggesting a promising avenue for this specific investigation.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Scott, Jessica — Sloan-Kettering Inst Can Research
- Study coordinator: Scott, Jessica
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.