Condition

Locally Advanced Rectal Cancer clinical trials and research

• 19Clinical trials
• 8NIH research projects
• 8Countries

Newest Locally Advanced Rectal Cancer clinical trials

All recruiting trials (19)

• Brachytherapy and Nivolumab Before Surgery for Rectal Cancer

  This small Phase II study tests whether targeted internal radiation therapy followed by two doses of nivolumab can be safely given before rectal cancer surgery to see if it helps the treatment work.

  Recruiting Phase 2 Sir Mortimer B. Davis - Jewish General Hospital · Montreal, Quebec · NCT07645118

• Camrelizumab with long-course chemoradiotherapy before surgery for locally advanced low rectal cancer (pMMR/MSS)

  This trial tests whether giving camrelizumab before and after long-course chemoradiotherapy helps people with locally advanced, pMMR/MSS low rectal cancer achieve a higher complete response and preserve the rectum.

  Recruiting Phase 2 Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT07527026

• Galenos 2: Immunonutrition for head and neck, lung, and rectal cancer patients

  This trial tests whether taking a twice-daily galenic immunonutrition supplement can reduce side effects and help people with head and neck, lung, or locally advanced rectal cancer complete their cancer therapy.

  Recruiting Fondazione del Piemonte per l'Oncologia · Candiolo, Torino (TO) · NCT07514754

• GALENOS 1: Longitudinal nutrition and body composition in head and neck, lung, and rectal cancer patients

  This project will see how nutritional status and body composition change over time in adults with head and neck, lung, or locally advanced rectal cancer who are receiving standard anticancer treatments.

  Recruiting Fondazione del Piemonte per l'Oncologia · Candiolo, Torino (TO) · NCT07511413

• Short-Course RT with CAPOX and Tislelizumab vs Long-Course RT with Tislelizumab for Locally Advanced Rectal Cancer

  This study tests whether a shorter radiotherapy course with CAPOX chemotherapy and the PD-1 blocker tislelizumab works as well as the standard longer radiotherapy approach for locally advanced rectal cancer.

  Recruiting Phase 2 Fujian Cancer Hospital · Fuzhou, Fujian and 2 other locations · NCT07469306

• Long-course chemoradiation or short-course radiation with CAPOX, PD-1 antibody, and celecoxib for MSS locally advanced rectal cancer

  This trial tests whether adding a PD‑1 immune drug and the anti‑inflammatory celecoxib to standard CAPOX chemotherapy with either long- or short-course radiotherapy helps people with MSS locally advanced rectal cancer achieve a complete response before surgery.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT07150949

• Chemoradiotherapy with NALIRIFOX for advanced rectal cancer

  This study is testing a new treatment combining chemotherapy and radiation for people with advanced rectal cancer to see if it works better than the usual treatments.

  Recruiting Peking University Cancer Hospital & Institute · Beijing · NCT06894797

• MR-guided adaptive radiotherapy with immunotherapy for advanced rectal cancer

  This study is testing a new treatment that combines special radiation therapy, an immune therapy drug, and chemotherapy to see if it helps people with advanced rectal cancer respond better before surgery.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT06840665

• Short-course radiotherapy followed by AK112 and CAPOX for advanced rectal cancer

  This study is testing a new treatment plan that combines short radiation therapy with two medications for people with advanced rectal cancer to see if it works better than the usual treatments.

  Recruiting Phase 2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Hubei · NCT06802666

• CAPOX plus PD-1 antibody (toripalimab) with or without short-course radiotherapy for MSS locally advanced rectal cancer

  This trial will try toripalimab combined with CAPOX chemotherapy, with or without a short course of radiotherapy, to see if it increases complete response rates in adults with MSS locally advanced rectal cancer.

  Recruiting Phase 2 Fudan University · Shanghai · NCT06281405

• Short-course radiotherapy with Fruquintinib and Adebrelimab for advanced rectal cancer

  This study is testing a new treatment plan that combines short radiation therapy with Fruquintinib and Adebrelimab for people with advanced rectal cancer to see if it helps them better than current methods.

  Recruiting Phase 2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan · NCT06234007

• Node-sparing radiotherapy with chemotherapy and immunotherapy for rectal cancer

  This study is testing a new way to treat locally advanced rectal cancer using targeted radiation, chemotherapy, and immunotherapy to see if it helps patients keep their organs and live longer.

  Recruiting Phase 2 Jinhua Central Hospital · Jinhua, Zhejiang · NCT06204094

• Comparing two treatment options for older patients with advanced rectal cancer

  This study is testing whether short course radiotherapy or total neoadjuvant therapy works better for older patients with advanced rectal cancer.

  Recruiting at 15 sites Jules Bordet Institute · Antwerp, Antwerpen and 18 other locations · NCT06052332

• Combining preoperative radiotherapy with ASTX660 for rectal cancer treatment

  This study tests two different treatment plans for people with locally-advanced rectal cancer to see which one works better when combined with a new drug called ASTX660.

  Recruiting Phase 1 Gustave Roussy, Cancer Campus, Grand Paris · Lyon, Rhöne and 1 other locations · NCT05912075

• Comparing two treatment approaches for locally advanced rectal cancer

  This study is testing if a new combination of radiation and chemotherapy can help people with locally advanced rectal cancer respond better to treatment and possibly avoid major surgery.

  Recruiting at 34 sites Phase 3 National Cancer Center Hospital East · Chiba and 33 other locations · NCT05646511

• Chemotherapy followed by high-dose radiation for locally advanced rectal cancer

  This study is testing if giving chemotherapy followed by a higher dose of radiation can help people with locally advanced rectal cancer avoid surgery by seeing if it leads to a complete response.

  Recruiting Phase 1 University of Miami · Miami, Florida · NCT05412082

• Combining chemoradiation with PD-1 blockade for advanced rectal cancer treatment

  This study is testing if combining a new immune therapy with standard treatment helps people with advanced rectal cancer do better than just using the standard treatment alone.

  Recruiting at 4 sites Phase 2 Beijing Friendship Hospital · Beijing, Beijing Municipality and 7 other locations · NCT05245474

• Adaptive MRI-guided Radiotherapy in Rectal Cancer to See If High Dose Helps Some Patients

  This trial tests whether increasing radiation dose during treatment helps rectal cancer patients who show poorer early response on MRI-guided therapy.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, Roma · NCT04815694

• Organ preservation approach for locally advanced rectal cancer

  This study is testing if a new approach to treating locally advanced rectal cancer can safely help patients keep their organs while monitoring their recovery after treatment.

  Recruiting Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · Elche, Alicante · NCT03064646

NIH-funded research (8)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Blood tests to predict who will respond to pre-surgery therapy for locally advanced rectal cancer

  A blood-based test is being developed to predict which patients with locally advanced rectal cancer will respond to neoadjuvant chemoradiation before surgery.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11330520

• Predicting who responds to preoperative therapy for rectal cancer using combined photoacoustic and ultrasound imaging

  A study is testing a new imaging method to better predict which locally advanced rectal cancer patients will respond to preoperative treatment so some may avoid unnecessary surgery.

  NIH research Washington University · Saint Louis, United States · NIH-11328818

• Dose levels of aerobic exercise during cancer therapy for rectal cancer

  A personalized exercise plan is tested to see how different amounts of aerobic training affect how well people with locally advanced rectal cancer tolerate their treatment.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11325432

• Tucatinib and trastuzumab given before other treatments for HER2‑positive rectal cancer

  People with HER2‑positive locally advanced rectal cancer will receive tucatinib plus trastuzumab up front to shrink tumors and possibly avoid radiation or surgery.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11302663

• Identifying blood markers to predict treatment response in rectal cancer patients

  This study is looking at how a new blood test can help doctors figure out which patients with locally advanced rectal cancer will respond well to their treatment before they start, so they can tailor the therapy to each person and avoid unnecessary side effects.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11143949

• Using advanced imaging to predict treatment response in rectal cancer

  This study is looking to help people with locally advanced rectal cancer by using new imaging methods to better understand how well they respond to treatment before surgery, which could help doctors make smarter choices and possibly spare some patients from unnecessary operations.

  NIH research Washington University · Saint Louis, United States · NIH-11088143

• Effects of aerobic training on cancer treatment tolerability in rectal cancer patients

  This study is looking at how different amounts of aerobic exercise can help people with locally advanced rectal cancer feel better and handle their treatment more easily, and it’s designed for patients who are about to start their cancer therapy.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11056086

• Targeted therapy for advanced rectal cancer with HER2 amplification

  This study is testing a new way to treat patients with a specific type of rectal cancer by using targeted medicines before the usual chemotherapy and surgery, hoping to shrink tumors and make treatment easier with fewer side effects.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11042258

Related topics

Quick answers

How many Locally Advanced Rectal Cancer clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in China (10 trials), Italy (3 trials), Belgium (1 trial), Canada (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 10, Phase 1: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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