Sintilimab plus bevacizumab biosimilar before surgery for resectable liver cancer

Sintilimab Combined With Bevacizumab as Neoadjuvant Therapy for Resectable Hepatocellular Carcinoma Beyond the Milan Criteria: A Single-Arm, Prospective Phase II Study

This trial will test whether giving sintilimab together with a bevacizumab biosimilar before surgery helps people with resectable hepatocellular carcinoma beyond the Milan criteria.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 37 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Sun Yat-sen University (Academic / other)
• Drugs / interventions: sintilimab, bevacizumab, prednisone, immunotherapy
• Locations: 1 site (Guangzhou, Guangdong)
• Trial ID: NCT07324824 on ClinicalTrials.gov

What this trial studies

This is a prospective, single-arm phase II trial testing neoadjuvant sintilimab combined with a bevacizumab biosimilar in patients with resectable hepatocellular carcinoma beyond the Milan criteria. Eligible adults must have no prior anti-HCC treatment, Child-Pugh A liver function, and ECOG 0-1. Participants receive the combination therapy prior to planned surgical resection with the goal of reducing postoperative recurrence and improving survival. The regimen builds on positive results of the sintilimab plus bevacizumab biosimilar combination in advanced HCC but applies it in the preoperative setting.

Who should consider this trial

Good fit: Adults (≥18) with clinically or pathologically confirmed resectable hepatocellular carcinoma beyond the Milan criteria, no prior HCC therapy, Child-Pugh A liver function, ECOG 0-1, and adequate organ and bone marrow function are ideal candidates.

Not a fit: Patients with mixed or non-HCC histology (e.g., cholangiocarcinoma), prior organ transplant, recent severe portal hypertensive bleeding, symptomatic large ascites/effusions, or poor liver function beyond Child-Pugh A are unlikely to benefit from this regimen.

Why it matters

Potential benefit: If successful, this approach could shrink tumors before surgery, lower the chance of cancer coming back after resection, and improve long-term survival.

How similar studies have performed: The phase III ORIENT-32 trial showed benefit of sintilimab plus a bevacizumab biosimilar in advanced HCC, but using this combination as neoadjuvant therapy for resectable disease is a newer application.

Eligibility criteria

Inclusion Criteria:

1. Able to provide informed consent and willing to sign an approved consent form;
2. Aged ≥ 18 years;
3. Clinically diagnosed or pathologically confirmed resectable hepatocellular carcinoma beyond the Milan criteria (CNLC Ib-IIa);
4. No prior anti-HCC treatment;
5. Child-Pugh class A.
6. Eastern Cooperative Oncology Group (ECOG) performance status score of 0-1.
7. Expected survival time of \> 6 months.
8. Sufficient organ and bone marrow function.

Exclusion Criteria:

1. Known as cholangiocarcinoma (ICC) or mixed hepatocellular carcinoma, sarcomatoid hepatocellular carcinoma, and hepatic fibrolamellar carcinoma;
2. History of organ transplantation or hepatic encephalopathy
3. Pleural fluid, ascites, and pericardial effusion with clinical symptoms requiring drainage
4. History of esophageal or gastric variceal bleeding caused by portal hypertension within the past 6 months; Documented severe (Grade 3) varices identified by endoscopy within 3 months prior to enrollment; Evidence of portal hypertension and assessed by the investigator as being at high risk of bleeding.
5. Arterial and venous thromboembolic events in the past 6 months, including myocardial infarction, unstable angina, cerebrovascular accident or transient ischemic attack, pulmonary embolism, deep vein thrombosis or any other serious thromboembolism history;
6. Any life-threatening bleeding event occurring within the past 3 months;
7. Severe bleeding tendency, coagulopathy, or ongoing thrombolytic therapy.
8. Chronic requirement for medications that inhibit platelet function, such as aspirin (\>325 mg/day), dipyridamole, or clopidogrel.
9. Uncontrolled hypertension, defined as systolic blood pressure \>140 mmHg or diastolic blood pressure \>90 mmHg despite optimal medical management; history of hypertensive crisis or hypertensive encephalopathy.
10. Symptomatic congestive heart failure (New York Heart Association \[NYHA\] Functional Class II-IV); symptomatic or poorly controlled arrhythmias; history of congenital long QT syndrome; or corrected QT interval (QTc) \>500 ms at screening (calculated using Fridericia's formula).
11. History of gastrointestinal perforation and/or fistula, intestinal obstruction (including incomplete obstruction requiring parenteral nutrition), extensive bowel resection (partial colectomy or extensive small bowel resection complicated by chronic diarrhea), Crohn's disease, ulcerative colitis, or chronic persistent diarrhea within the past 6 months.
12. Major surgical procedure (craniotomy, thoracotomy, or laparotomy) within 4 weeks prior to enrollment; presence of unhealed wounds, ulcers, or fractures; or tissue biopsy or other minor surgical procedure within 7 days prior to enrollment, excluding venous catheterization for intravenous infusion.
13. Past or current history of pulmonary diseases including pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, drug-induced pneumonia, or severe impairment of lung function.
14. Active acute or chronic hepatitis B or C infection, defined as: hepatitis B virus (HBV) DNA \>2000 IU/mL or 10⁴ copies/mL; hepatitis C virus (HCV) RNA \>10³ copies/mL; or concurrent positivity for hepatitis B surface antigen (HBsAg) and anti-HCV antibodies.
15. Active tuberculosis (TB); ongoing anti-TB treatment; or anti-TB treatment completed within 1 year prior to the initiation of study treatment.
16. Human immunodeficiency virus (HIV) infection (positive for HIV 1/2 antibodies); known syphilis infection.
17. Severe active infection or infection with poor clinical control.
18. Active autoimmune disease requiring systemic therapy (e.g., disease-modifying antirheumatic drugs, corticosteroids, or immunosuppressants) within 2 years prior to enrollment. Substitution therapy (e.g., thyroid hormone, insulin, or physiological doses of corticosteroids for adrenal or pituitary insufficiency) is permitted. A history of known primary immunodeficiency is excluded. Patients with isolated positive autoimmune antibodies must be evaluated by the investigator to confirm the absence of underlying autoimmune disease.
19. Use of immunosuppressive drugs within 4 weeks prior to enrollment, excluding intranasal, inhaled, or other topical corticosteroids, or systemic corticosteroids at physiological doses (i.e., ≤10 mg/day of prednisone or equivalent). Temporary use of corticosteroids for the management of dyspnea related to asthma, chronic obstructive pulmonary disease (COPD), or other conditions is permitted.
20. Administration of live-attenuated vaccines within 4 weeks prior to enrollment or planned administration of live-attenuated vaccines during the study period.
21. Use of immunomodulatory agents (including thymosin, interferons, or interleukins) within 2 weeks prior to enrollment, excluding local administration for the control of pleural effusion or ascites.
22. Uncontrolled/uncorrectable metabolic disorders, other non-malignant organ/systemic diseases, or cancer-related sequelae that pose a high medical risk and/or introduce uncertainty in survival assessment.
23. Diagnosis of other malignant tumors within 5 years prior to enrollment, excluding curatively treated basal cell carcinoma of the skin, squamous cell carcinoma of the skin, and/or curatively resected carcinoma in situ. For malignant tumors diagnosed more than 5 years prior to drug administration, pathological or cytological confirmation of recurrent or metastatic lesions is required.
24. Prior receipt of any anti-angiogenic agents, anti-PD-1 antibodies, anti-PD-L1/L2 antibodies, anti-CTLA-4 antibodies, or other immunotherapies.
25. Known hypersensitivity to sintilimab, bevacizumab formulations, or their excipients; or history of severe hypersensitivity reactions to other monoclonal antibodies.
26. Receipt of treatment in other clinical trials within 4 weeks prior to enrollment.
27. Pregnant or breastfeeding female patients.
28. Other acute or chronic diseases, psychiatric disorders, or abnormal laboratory findings that, in the investigator's judgment, would: increase the risk associated with study participation or study drug administration; interfere with the interpretation of study results; or render the patient ineligible for study participation.

Where this trial is running

Guangzhou, Guangdong

• Sun Yat-sen University Cancer Center — Guangzhou, Guangdong, China (Recruiting)

Conditions Hepatocellular Carcinoma; Neoadjuvant Therapy; Sintilimab; Bevacizimab