Symani Restore surgery for Moyamoya disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, interventional study of the Symani Surgical System in adults with moyamoya disease who require neurosurgical treatment. Eligible patients (>18 years) will undergo the planned surgical procedure with the aid of the Symani device and will be followed for safety and device-related outcomes. The trial enrolls patients at the Jacobs Institute in Buffalo, New York, and applies standard inclusion and exclusion criteria for operative candidates. Investigators will record perioperative safety, technical performance, and clinical recovery measures to determine device effectiveness in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients aged \>18.
2. Moyamoya disease with minor to moderate symptoms requiring neurosurgical treatment.
3. Patients agree to have the surgery and the anesthesia.
4. Patients who voluntarily decide to participate in this study with the surgery performed with the aid of Symani and agree to sign the Informed Consent Form.

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Exclusion Criteria:

1. Patients who have bleeding or coagulation disorders in the past or present.
2. Any criteria that preclude prolonged anesthesia.
3. Hemodynamically unstable neurological exam.
4. Pressure dependent neurologic status.

Where it's running

• Jacobs Institute
  Buffalo, New York, United States Recruiting

Study contacts

• Study coordinator: CARLOS PENA, PhD, MS
• Email: cpena@jacobsinstitute.org
• Phone: 17168884814

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• 5T MRI and Metabolomics to Predict Hemorrhage Risk in Moyamoya Disease

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• XR-assisted CT-guided localization for EC-IC bypass in Moyamoya and chronic cerebral ischemia

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• Family screening and early detection for moyamoya disease

  This project will try to find biological signs and 5T high-resolution MRI features that could detect moyamoya earlier in people with the disease, their first-degree relatives, and people without a family history.

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• Remimazolam: target-controlled infusion versus manual infusion during cerebrovascular bypass

  This trial will test whether target-controlled infusion uses less remimazolam than manual infusion in adults undergoing cerebrovascular bypass surgery for moyamoya disease.

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• Cardiac index–guided blood flow management during pediatric Moyamoya EDAS surgery

  This study will test whether using each child's cardiac index to guide fluids and hemodynamic care during EDAS lowers postoperative transient ischemic episodes in children with Moyamoya disease.

  Recruiting Seoul National University Hospital · Seoul · NCT07304947

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.