Combined cognitive and motor training for people with stroke or Moyamoya disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project begins with a cross-sectional comparison of adults with post-stroke cognitive impairment, adults with Moyamoya disease, and age-matched healthy controls, with 30 participants in each group. All participants will undergo standardized cognitive tests (global cognition and executive function), motor tests (sensorimotor measures, single- and dual-task standing, strength, and walking), and brain activation imaging to map neural patterns. The aim is to characterize how cognitive and motor impairments relate to brain activation across these groups. These baseline data will inform the design and potential application of a motor-cognitive incorporated training (MCIT) intervention in subsequent parts of the project.

Why it matters

Who can join: the full rules

Part 1:

Inclusion Criteria:

* For aged-matched healthy controls:

  1. being 20 years of age or older
  2. the ability to stand for more than 30 seconds
  3. a MoCA score of higher than 26.
* For PSCI participants:

  1. Diagnosis of stroke confirmed by brain CT or MRI, with symptom onset more than 7 days prior (subacute or chronic phase)
  2. Being 20 years of age or older
  3. The ability to stand for more than 30 seconds
  4. a MoCA score of less than 26
* For the MMD group:

  1. a confirmed diagnosis of Moyamoya disease or Moyamoya syndrome through CT scan or angiography
  2. If stroke occurred, being in the subacute phase (one week post-stroke)
  3. being 20 years of age or older
  4. the ability to stand for more than 30 seconds
  5. a MoCA score of less than 26

Exclusion Criteria:

1. unstable or uncontrolled vital signs, including a resting heart rate \>100 or \<40 BPM, a respiratory rate \>20 or \<12 breaths per minute, an SpO2 \< 95%, a central arterial pressure (CAP) \<80 mmHg, and individuals requiring ICP monitoring will also be excluded
2. requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions
3. the presence of other neurological disorders or unstable vital signs may interfere with the experiment
4. currently hospitalized in the intensive care unit (ICU)
5. Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation

Part 2:

Inclusion Criteria:

1. Diagnosis of stroke confirmed by brain CT or MRI, with symptom onset more than 7 days prior (subacute or chronic phase)
2. Being 20 years of age or older
3. The ability to stand for more than 30 seconds
4. a MoCA score of less than 26

Exclusion Criteria:

1. unstable or uncontrolled vital signs, including a resting heart rate \>100 or \<40 BPM, a respiratory rate \>20 or \<12 breaths per minute, an SpO2 \< 95%, a central arterial pressure (CAP) \<80 mmHg, and individuals requiring ICP monitoring will also be excluded
2. requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions
3. the presence of other neurological disorders or unstable vital signs may interfere with the experiment
4. currently hospitalized in the intensive care unit (ICU)
5. Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation

Part 3:

Inclusion Criteria:

1. Moyamoya disease/syndrome confirmed through CT scan or angiography
2. being in the subacute phase, defined as one week after stroke onset
3. being 20 years of age or older
4. the ability to stand for more than 30 seconds
5. a Montreal Cognitive Assessment (MoCA) score of less than 26.

Exclusion Criteria:

1. unstable or uncontrolled vital signs, including a resting heart rate \>100 or \<40 BPM, a respiratory rate \>20 or \<12 breaths per minute, an SpO2 \< 95%, a central arterial pressure (CAP) \<80 mmHg, and individuals requiring ICP monitoring will also be excluded
2. requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions
3. the presence of other neurological disorders or unstable vital signs that could interfere with the experiment
4. currently hospitalized in the intensive care unit (ICU)
5. Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation.

Where it's running

• National Taiwan University
  Taipei, Taiwan Recruiting

Study contacts

• Principal investigator: Yan Ci Liu, PhD — National Taiwan University
• Study coordinator: Yan Ci Liu, PhD
• Email: yanciliu@ntu.edu.tw
• Phone: +886233668135

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.