Combined cognitive and motor training for people with stroke or Moyamoya disease

Impact of Cognitive-Motor Incorporated Training and Brain Activation Patterns in Cerebrovascular Diseases With Cognitive and Motor Impairments: Post Stroke Cognitive Impairment and Moyamoya Disease

This trial will test whether combined cognitive-motor training helps people with post-stroke cognitive impairment or Moyamoya disease improve their thinking and movement.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 210 (estimated)
• Ages: 20 Years to 100 Years
• Sex: All
• Sponsor: National Taiwan University Hospital (other)
• Locations: 1 site (Taipei)
• Trial ID: NCT07144930 on ClinicalTrials.gov

What this trial studies

This project begins with a cross-sectional comparison of adults with post-stroke cognitive impairment, adults with Moyamoya disease, and age-matched healthy controls, with 30 participants in each group. All participants will undergo standardized cognitive tests (global cognition and executive function), motor tests (sensorimotor measures, single- and dual-task standing, strength, and walking), and brain activation imaging to map neural patterns. The aim is to characterize how cognitive and motor impairments relate to brain activation across these groups. These baseline data will inform the design and potential application of a motor-cognitive incorporated training (MCIT) intervention in subsequent parts of the project.

Who should consider this trial

Good fit: Ideal candidates are adults aged 20 or older who can stand for at least 30 seconds, including people with a confirmed stroke (subacute or chronic) or confirmed Moyamoya disease with MoCA scores below 26, as well as age-matched healthy volunteers with MoCA above 26.

Not a fit: People with unstable or uncontrolled vital signs, those who cannot safely stand for 30 seconds, or patients with medical conditions that prevent safe participation are unlikely to benefit from this protocol.

Why it matters

Potential benefit: If successful, this approach could lead to training programs that improve both thinking and movement in people with stroke-related cognitive problems or Moyamoya disease.

How similar studies have performed: Previous combined cognitive-motor rehabilitation programs have shown promise in improving cognition and dual-task mobility after stroke, but applying MCIT specifically to Moyamoya disease is largely novel.

Eligibility criteria

Part 1:

Inclusion Criteria:

* For aged-matched healthy controls:

  1. being 20 years of age or older
  2. the ability to stand for more than 30 seconds
  3. a MoCA score of higher than 26.
* For PSCI participants:

  1. Diagnosis of stroke confirmed by brain CT or MRI, with symptom onset more than 7 days prior (subacute or chronic phase)
  2. Being 20 years of age or older
  3. The ability to stand for more than 30 seconds
  4. a MoCA score of less than 26
* For the MMD group:

  1. a confirmed diagnosis of Moyamoya disease or Moyamoya syndrome through CT scan or angiography
  2. If stroke occurred, being in the subacute phase (one week post-stroke)
  3. being 20 years of age or older
  4. the ability to stand for more than 30 seconds
  5. a MoCA score of less than 26

Exclusion Criteria:

1. unstable or uncontrolled vital signs, including a resting heart rate \>100 or \<40 BPM, a respiratory rate \>20 or \<12 breaths per minute, an SpO2 \< 95%, a central arterial pressure (CAP) \<80 mmHg, and individuals requiring ICP monitoring will also be excluded
2. requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions
3. the presence of other neurological disorders or unstable vital signs may interfere with the experiment
4. currently hospitalized in the intensive care unit (ICU)
5. Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation

Part 2:

Inclusion Criteria:

1. Diagnosis of stroke confirmed by brain CT or MRI, with symptom onset more than 7 days prior (subacute or chronic phase)
2. Being 20 years of age or older
3. The ability to stand for more than 30 seconds
4. a MoCA score of less than 26

Exclusion Criteria:

1. unstable or uncontrolled vital signs, including a resting heart rate \>100 or \<40 BPM, a respiratory rate \>20 or \<12 breaths per minute, an SpO2 \< 95%, a central arterial pressure (CAP) \<80 mmHg, and individuals requiring ICP monitoring will also be excluded
2. requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions
3. the presence of other neurological disorders or unstable vital signs may interfere with the experiment
4. currently hospitalized in the intensive care unit (ICU)
5. Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation

Part 3:

Inclusion Criteria:

1. Moyamoya disease/syndrome confirmed through CT scan or angiography
2. being in the subacute phase, defined as one week after stroke onset
3. being 20 years of age or older
4. the ability to stand for more than 30 seconds
5. a Montreal Cognitive Assessment (MoCA) score of less than 26.

Exclusion Criteria:

1. unstable or uncontrolled vital signs, including a resting heart rate \>100 or \<40 BPM, a respiratory rate \>20 or \<12 breaths per minute, an SpO2 \< 95%, a central arterial pressure (CAP) \<80 mmHg, and individuals requiring ICP monitoring will also be excluded
2. requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions
3. the presence of other neurological disorders or unstable vital signs that could interfere with the experiment
4. currently hospitalized in the intensive care unit (ICU)
5. Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation.

Where this trial is running

Taipei

• National Taiwan University — Taipei, Taiwan (RECRUITING)

Study contacts

• Principal investigator: Yan Ci Liu, PhD — National Taiwan University
• Study coordinator: Yan Ci Liu, PhD

Conditions: Moyamoya Disease, Healthy, Stroke, Motor-cognitive incorporated training, Cognitive function, Motor function, Post-stroke cognitive impairment