Evaluating cognitive impairment in moyamoya disease patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the risk factors for cognitive decline in patients diagnosed with moyamoya disease. It will utilize advanced techniques such as high-density electroencephalography and multimodal magnetic resonance imaging to identify brain areas affected by cognitive damage. Additionally, the study will explore how cerebral revascularization impacts brain structure and functional networks, and its relationship with cognitive improvement. By understanding these mechanisms, the research seeks to provide insights into the cognitive challenges faced by these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The admission cerebral angiography (DSA) examination fulfills the diagnostic criteria for moyamoya disease.
* Please sign the informed consent form.
* Participants must be between 18 and 60 years of age.

Exclusion Criteria:

* Patients with concurrent atherosclerosis, autoimmune diseases, meningitis, brain tumors, Down syndrome, craniocerebral trauma, prior radioactive head irradiation, or hyperthyroidism, which may result in secondary cerebrovascular lesions leading to symptoms associated with smoke syndrome.
* Individuals younger than 18 years or older than 60 years.
* Those with contraindications for magnetic resonance imaging.
* Patients who are unable to complete cognitive brain assessments

Where it's running

• Beijing Tiantan Hospital
  Beijing, China, China Recruiting

Study contacts

• Study coordinator: Qian Zhang, MD
• Email: zhangqianchina@yahoo.com
• Phone: 8613120012579

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Risk prediction for stroke and cognitive decline in Moyamoya disease and Moyamoya syndrome

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• 5T MRI and Metabolomics to Predict Hemorrhage Risk in Moyamoya Disease

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• XR-assisted CT-guided localization for EC-IC bypass in Moyamoya and chronic cerebral ischemia

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• Family screening and early detection for moyamoya disease

  This project will try to find biological signs and 5T high-resolution MRI features that could detect moyamoya earlier in people with the disease, their first-degree relatives, and people without a family history.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07517354

• Remimazolam: target-controlled infusion versus manual infusion during cerebrovascular bypass

  This trial will test whether target-controlled infusion uses less remimazolam than manual infusion in adults undergoing cerebrovascular bypass surgery for moyamoya disease.

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• Cardiac index–guided blood flow management during pediatric Moyamoya EDAS surgery

  This study will test whether using each child's cardiac index to guide fluids and hemodynamic care during EDAS lowers postoperative transient ischemic episodes in children with Moyamoya disease.

  Recruiting Seoul National University Hospital · Seoul · NCT07304947

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.