Understanding how blood flow and brain health relate to treatment in moyamoya disease
Personalized hemodynamic and metabolic signatures of revascularization response in moyamoya disease
This study is looking at how blood flow and certain markers can help us understand the risk of strokes in people with moyamoya disease, so we can better identify who might benefit from surgery to improve their condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11074611 on NIH RePORTER |
What this research studies
This research investigates the relationship between blood flow, stroke risk biomarkers, and cerebrospinal fluid movement in patients with moyamoya disease, a condition that can lead to severe strokes. By utilizing advanced neuroimaging and angiographic techniques, the study aims to identify which patients are most likely to benefit from surgical revascularization. The research is conducted across multiple sites, including Vanderbilt University Medical Center and Johns Hopkins University, focusing on North American patients. The goal is to improve treatment strategies and outcomes for individuals affected by this rare disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with moyamoya disease, particularly those at high risk for stroke.
Not a fit: Patients with moyamoya disease who are not at risk for stroke or who have already undergone treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for patients with moyamoya disease.
How similar studies have performed: While there has been significant research into cerebrovascular diseases, this specific approach to moyamoya disease is novel and has not been extensively tested.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Donahue, Manus J — Vanderbilt University Medical Center
- Study coordinator: Donahue, Manus J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.