Understanding how blood flow and brain health relate to treatment in moyamoya disease
Official title: Personalized hemodynamic and metabolic signatures of revascularization response in moyamoya disease
Funded at Vanderbilt University Medical Center · NIH-11074611 · Data updated 2026-11-12
This study is looking at how blood flow and certain markers can help us understand the risk of strokes in people with moyamoya disease, so we can better identify who might benefit from surgery to improve their condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $576,014 |
| NIH project number | 5R01NS133101-02 |
| Project ID | NIH-11074611 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with moyamoya disease, particularly those at high risk for stroke.
✕Less likely to help
Patients with moyamoya disease who are not at risk for stroke or who have already undergone treatment may not benefit from this research.
What this research studies
This research investigates the relationship between blood flow, stroke risk biomarkers, and cerebrospinal fluid movement in patients with moyamoya disease, a condition that can lead to severe strokes. By utilizing advanced neuroimaging and angiographic techniques, the study aims to identify which patients are most likely to benefit from surgical revascularization. The research is conducted across multiple sites, including Vanderbilt University Medical Center and Johns Hopkins University, focusing on North American patients. The goal is to improve treatment strategies and outcomes for individuals affected by this rare disease.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for patients with moyamoya disease.
How similar studies have gone: While there has been significant research into cerebrovascular diseases, this specific approach to moyamoya disease is novel and has not been extensively tested.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Donahue, Manus J — Vanderbilt University Medical Center
- Study coordinator: Donahue, Manus J
Related research
Other NIH-funded projects on the same topics.
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RNF213 and Moyamoya Disease in Children
A study in young children will explore how the RNF213 gene affects blood vessel cells and contributes to Moyamoya disease, with the aim of finding new ways to prevent or treat strokes.
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Personalized vascular and metabolic signs after revascularization in moyamoya disease
A multi-site study will look at brain imaging and blood/CSF signals in adults with moyamoya disease to understand which biomarkers relate to stroke risk and how patients respond to treatment.
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Investigating the role of a gene in the development of Moyamoya disease
This study is looking at how a specific gene called SETD5 affects Moyamoya disease, which causes blood vessels in the brain to narrow and can lead to strokes, especially in kids, with the goal of finding new ways to help improve treatment for patients.
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Risk prediction for stroke and cognitive decline in Moyamoya disease and Moyamoya syndrome
A large multicenter study tests whether combining clinical data, imaging, lab and genetic information can predict who will have stroke or cognitive decline among people with Moyamoya.
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5T MRI and Metabolomics to Predict Hemorrhage Risk in Moyamoya Disease
This study tests whether advanced 5T MRI imaging and metabolomics can help predict which moyamoya patients are at higher risk of intracranial hemorrhage.
-
XR-assisted CT-guided localization for EC-IC bypass in Moyamoya and chronic cerebral ischemia
The study tests whether a metaverse-based surgical simulation with extended reality helps localize vessels during EC-IC bypass for moyamoya disease or chronic cerebral ischemia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.