Observing brain networks in moyamoya disease patients under anesthesia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with moyamoya disease who are scheduled for revascularization surgery. It utilizes functional Magnetic Resonance Imaging (fMRI) to assess changes in cerebral blood flow, oxygen metabolism, and network connectivity during anesthesia. The aim is to understand how these factors influence neurological functions post-surgery, which is crucial for effective perioperative management. By monitoring these parameters, the study seeks to enhance the understanding of cerebral dynamics in patients with compromised vascular networks.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with moyamoya disease scheduled for direct or indirect intracranial and extracranial revascularization surgery
* Age between 18-65 years
* Obtain written informed consent.

Exclusion Criteria:

* Patients with preoperative claustrophobia, sensory or motor aphasia that are unable to understand and cooperate with the examination
* Preoperative cranial imaging suggesting cerebral infarction lesion diameter \>15mm
* Patients allergic to anesthetic drugs
* Metal implants in the body
* Undergoing other experimental drug or instrumentation trials

Where it's running

• Beijing Tiantan Hospital, Capital Medical University
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Shu Li — Beijing Tiantan Hospital
• Study coordinator: Shu Li
• Email: lishu@bjtth.org
• Phone: 8613699223065

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Risk prediction for stroke and cognitive decline in Moyamoya disease and Moyamoya syndrome

  A large multicenter study tests whether combining clinical data, imaging, lab and genetic information can predict who will have stroke or cognitive decline among people with Moyamoya.

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• 5T MRI and Metabolomics to Predict Hemorrhage Risk in Moyamoya Disease

  This study tests whether advanced 5T MRI imaging and metabolomics can help predict which moyamoya patients are at higher risk of intracranial hemorrhage.

  Recruiting Beijing Hospital · Beijing, Beijing Municipality · NCT07781579

• XR-assisted CT-guided localization for EC-IC bypass in Moyamoya and chronic cerebral ischemia

  The study tests whether a metaverse-based surgical simulation with extended reality helps localize vessels during EC-IC bypass for moyamoya disease or chronic cerebral ischemia.

  Recruiting National Taiwan University Hospital · Taipei · NCT07711457

• Family screening and early detection for moyamoya disease

  This project will try to find biological signs and 5T high-resolution MRI features that could detect moyamoya earlier in people with the disease, their first-degree relatives, and people without a family history.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07517354

• Remimazolam: target-controlled infusion versus manual infusion during cerebrovascular bypass

  This trial will test whether target-controlled infusion uses less remimazolam than manual infusion in adults undergoing cerebrovascular bypass surgery for moyamoya disease.

  Recruiting Seoul National University Hospital · Seongnam-si, Gyeonggi-do · NCT07377695

• Cardiac index–guided blood flow management during pediatric Moyamoya EDAS surgery

  This study will test whether using each child's cardiac index to guide fluids and hemodynamic care during EDAS lowers postoperative transient ischemic episodes in children with Moyamoya disease.

  Recruiting Seoul National University Hospital · Seoul · NCT07304947

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.