Observing brain networks in moyamoya disease patients under anesthesia
Functional Magnetic Resonance-Based Observations of Brain Networks and Cerebrovascular Reactivity in Patients With Moyamoya Disease Under Anesthetic Sedation, A Prospective Observational Cohort Study
This study looks at how brain blood flow and activity change in patients with moyamoya disease while they are under anesthesia to help improve their care during surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 48 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Beijing Tiantan Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT06041659 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with moyamoya disease who are scheduled for revascularization surgery. It utilizes functional Magnetic Resonance Imaging (fMRI) to assess changes in cerebral blood flow, oxygen metabolism, and network connectivity during anesthesia. The aim is to understand how these factors influence neurological functions post-surgery, which is crucial for effective perioperative management. By monitoring these parameters, the study seeks to enhance the understanding of cerebral dynamics in patients with compromised vascular networks.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-65 with moyamoya disease scheduled for revascularization surgery.
Not a fit: Patients with severe preoperative conditions, such as significant cerebral infarction or those unable to cooperate with the examination, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved perioperative management strategies that minimize neurological impairments in moyamoya disease patients.
How similar studies have performed: While fMRI has been used in various cerebrovascular diseases, this specific application in moyamoya disease under anesthesia is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with moyamoya disease scheduled for direct or indirect intracranial and extracranial revascularization surgery * Age between 18-65 years * Obtain written informed consent. Exclusion Criteria: * Patients with preoperative claustrophobia, sensory or motor aphasia that are unable to understand and cooperate with the examination * Preoperative cranial imaging suggesting cerebral infarction lesion diameter \>15mm * Patients allergic to anesthetic drugs * Metal implants in the body * Undergoing other experimental drug or instrumentation trials
Where this trial is running
Beijing, Beijing Municipality
- Beijing Tiantan Hospital, Capital Medical University — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Principal investigator: Shu Li — Beijing Tiantan Hospital
- Study coordinator: Shu Li
- Email: lishu@bjtth.org
- Phone: 8613699223065
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.