Personalized vascular and metabolic signs after revascularization in moyamoya disease
Official title: Personalized hemodynamic and metabolic signatures of revascularization response in moyamoya disease
Funded at Vanderbilt University Medical Center · NIH-11327640 · Data updated 2026-11-12
A multi-site study will look at brain imaging and blood/CSF signals in adults with moyamoya disease to understand which biomarkers relate to stroke risk and how patients respond to treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $575,913 |
| NIH project number | 5R01NS133101-03 |
| Project ID | NIH-11327640 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with idiopathic moyamoya disease who are candidates for or being considered for revascularization or medical management, recruited at participating centers.
✕Less likely to help
Patients without moyamoya or those not undergoing treatment decisions may not directly benefit from this research.
What this research studies
This project collaborates with Vanderbilt and Johns Hopkins to use cutting-edge brain imaging and vascular assessments in North American adults with moyamoya disease. The goal is to identify biomarkers that reflect stroke risk, vessel blockage, and CSF dynamics to inform who might benefit most from revascularization versus other care options. The study acknowledges that moyamoya in North America may differ from traditional descriptions and aims to clarify these factors using human patient data and advanced imaging analyses. It emphasizes a translational approach by linking imaging findings to treatment candidacy and disease mechanisms. Results could guide personalized treatment decisions and future trials in this patient population.
Why it matters
Potential benefit: If successful, the work could help clinicians personalize treatment decisions for moyamoya patients based on biomarker profiles and imaging signs.
How similar studies have gone: Prior work has broadened understanding of moyamoya, but large-scale biomarker-guided treatment decisions in North American patients remain limited, making this approach novel.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Donahue, Manus J — Vanderbilt University Medical Center
- Study coordinator: Donahue, Manus J
Related research
Other NIH-funded projects on the same topics.
-
RNF213 and Moyamoya Disease in Children
A study in young children will explore how the RNF213 gene affects blood vessel cells and contributes to Moyamoya disease, with the aim of finding new ways to prevent or treat strokes.
-
Understanding how blood flow and brain health relate to treatment in moyamoya disease
This study is looking at how blood flow and certain markers can help us understand the risk of strokes in people with moyamoya disease, so we can better identify who might benefit from surgery to improve their condition.
-
Investigating the role of a gene in the development of Moyamoya disease
This study is looking at how a specific gene called SETD5 affects Moyamoya disease, which causes blood vessels in the brain to narrow and can lead to strokes, especially in kids, with the goal of finding new ways to help improve treatment for patients.
-
Risk prediction for stroke and cognitive decline in Moyamoya disease and Moyamoya syndrome
A large multicenter study tests whether combining clinical data, imaging, lab and genetic information can predict who will have stroke or cognitive decline among people with Moyamoya.
-
5T MRI and Metabolomics to Predict Hemorrhage Risk in Moyamoya Disease
This study tests whether advanced 5T MRI imaging and metabolomics can help predict which moyamoya patients are at higher risk of intracranial hemorrhage.
-
XR-assisted CT-guided localization for EC-IC bypass in Moyamoya and chronic cerebral ischemia
The study tests whether a metaverse-based surgical simulation with extended reality helps localize vessels during EC-IC bypass for moyamoya disease or chronic cerebral ischemia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.