Understanding Mitral Valve Disease at a Molecular Level
Unraveling molecular Complexity of Mitral Valve Disease using single cell and Spatial Multi-Omics analysis"
This research aims to understand the tiny molecular details of mitral valve prolapse, a condition where heart valve leaflets thicken, by looking closely at patient samples.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11173572 on NIH RePORTER |
What this research studies
Mitral valve prolapse (MVP) causes heart valve leaflets to thicken, but we don't fully understand the specific molecular changes that start the disease. Current methods for studying gene activity in MVP haven't fully captured the differences between individual cells. This project will create a detailed map of the cells and molecules in mitral valve tissue from both MVP patients and healthy individuals. By using advanced single-cell and spatial technologies, we hope to uncover the precise molecular changes that lead to MVP.
Who could benefit from this research
Good fit: This research is focused on understanding mitral valve prolapse, so patients with this condition, as well as healthy individuals, may be ideal candidates for contributing samples.
Not a fit: Patients whose conditions are not related to mitral valve prolapse or its underlying molecular mechanisms would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a much deeper understanding of mitral valve prolapse, potentially paving the way for new ways to diagnose or treat the condition in the future.
How similar studies have performed: While bulk gene studies have been done, this approach uses novel single-cell and spatial technologies to provide a much more detailed and comprehensive view of the disease, which has not been widely applied to MVP research.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Liu, Yang — Yale University
- Study coordinator: Liu, Yang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.