Understanding the molecular details of mitral valve disease
Unraveling molecular Complexity of Mitral Valve Disease using single cell and Spatial Multi-Omics analysis"
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10858142
This study is looking at mitral valve prolapse (MVP) by exploring the tiny building blocks of the heart's mitral valve in both MVP patients and healthy people, to better understand what causes the condition and how it develops.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10858142 on ClinicalTrials.gov |
What this research studies
This research investigates mitral valve prolapse (MVP), a condition that affects 2-3% of people, by examining the molecular structures involved in the disease. Using advanced techniques like single-cell and spatial multi-omics analysis, the study aims to create a detailed molecular atlas of mitral valve samples from both MVP patients and healthy individuals. This approach will help identify specific cell types and molecular states associated with MVP, providing insights into the disease's onset and progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with mitral valve prolapse or those with healthy mitral valves for comparison.
Not a fit: Patients with other types of heart valve diseases unrelated to mitral valve prolapse may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with mitral valve disease.
How similar studies have performed: While there has been significant research on mitral valve disease, the use of single-cell and spatial omics approaches in this context is relatively novel and untested.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, YANG — YALE UNIVERSITY
- Study coordinator: LIU, YANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Barlows Syndrome