Understanding the molecular details of mitral valve disease
Official title: Unraveling molecular Complexity of Mitral Valve Disease using single cell and Spatial Multi-Omics analysis"
Funded at Yale University · NIH-10858142 · Data updated 2026-11-12
This study is looking at mitral valve prolapse (MVP) by exploring the tiny building blocks of the heart's mitral valve in both MVP patients and healthy people, to better understand what causes the condition and how it develops.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $462,133 |
| NIH project number | 1R01HL173271-01 |
| Project ID | NIH-10858142 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with mitral valve prolapse or those with healthy mitral valves for comparison.
✕Less likely to help
Patients with other types of heart valve diseases unrelated to mitral valve prolapse may not benefit from this research.
What this research studies
This research investigates mitral valve prolapse (MVP), a condition that affects 2-3% of people, by examining the molecular structures involved in the disease. Using advanced techniques like single-cell and spatial multi-omics analysis, the study aims to create a detailed molecular atlas of mitral valve samples from both MVP patients and healthy individuals. This approach will help identify specific cell types and molecular states associated with MVP, providing insights into the disease's onset and progression.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with mitral valve disease.
How similar studies have gone: While there has been significant research on mitral valve disease, the use of single-cell and spatial omics approaches in this context is relatively novel and untested.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Liu, Yang — Yale University
- Study coordinator: Liu, Yang
Related research
Other NIH-funded projects on the same topics.
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Understanding mitral valve disease at the single-cell level
A patient-centered study will map the cells and molecular patterns in mitral valve disease to understand why MVP develops and how it progresses.
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Understanding Mitral Valve Disease at a Molecular Level
This research aims to understand the tiny molecular details of mitral valve prolapse, a condition where heart valve leaflets thicken, by looking closely at patient samples.
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MRace Implant: A first look at fixing the mitral valve to reduce regurgitation
This single-arm study tests whether the MRace Implant and Delivery System can safely place a prosthesis to reduce severe mitral regurgitation in high-risk patients who may not be good candidates for open-heart surgery.
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Mitral Valve Calcification Imaging with TrueVue 3D Light Rendering
This study tests how well three-dimensional transesophageal echocardiography with TrueVue transillumination detects mitral valve calcifications compared with CT in adults.
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Tracking progression and consequences of heart valve disease
This project will follow adults with moderate or worse valve disease to see if clinical tests and imaging can predict when their condition will get worse.
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Surgical implantation of a polymer prosthetic mitral or aortic valve
This will test a surgically implanted polymer heart valve to see if it is safe and works well for adults who need mitral or aortic valve replacement.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.